Robert J Morin

US Patent:

40768260, Feb 28, 1978

Filed:

Aug 6, 1976

Appl. No.:

5/712453

Inventors:

Burton A. Christensen - Scotch Plains NJ
Robert B. Morin - Warren NJ
Edward Walton - Scotch Plains NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 3142
C07D49804

US Classification:

424272

Abstract:

3-(. beta. -Hydroxyethylidene)-6-(. alpha. -Hydroxyethyl)-7-oxo-4-oxaazabicyclo [3. 2. 0]heptane-2-carboxylic acid having the structural formula: ##STR1## and the pharmaceutically acceptable salt, ester and amide derivatives thereof are disclosed to be useful as antibiotics. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

US Patent:

40780686, Mar 7, 1978

Filed:

Apr 12, 1976

Appl. No.:

5/676253

Inventors:

Burton G. Christensen - Metuchen NJ
Robert B. Morin - Warren NJ
Edward Walton - Scotch Plains NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07D49804
A61K 3142

US Classification:

424272

Abstract:

3-(. beta. -aminoethylidene)-6-(. alpha. -hydroxyethyl)-7-oxo-4-oxaazabicyclo[3. 2. 0]heptane-2-carboxylic acid having the structural formula: ##STR1## and the pharmaceutically acceptable salt, ester and amide derivatives thereof are disclosed to be useful as antibiotics. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

US Patent:

40780678, Mar 7, 1978

Filed:

Apr 12, 1976

Appl. No.:

5/676262

Inventors:

Burton G. Christensen - Metuchen NJ
Robert B. Morin - Warren NJ
Edward Walton - Scotch Plains NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07D49804
A61K 3142

US Classification:

424272

Abstract:

3-(. beta. -aminoethylidene)-7-oxo-4-oxaazabicyclo [3. 2. 0]heptane-2-carboxylic acid and derivatives thereof having the structural formula: ##STR1## and the pharmaceutically acceptable salt, ester and amide derivatives thereof are disclosed to be useful as antibiotics. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

US Patent:

40575403, Nov 8, 1977

Filed:

Mar 17, 1976

Appl. No.:

5/667825

Inventors:

Ronald G. Micetich - Edmonton, CA
Robert B. Morin - Warren NJ
Kenneth E. Wilson - Edmonton, CA

Assignee:

Connlab Holdings Limited - Ontario

International Classification:

C07D20508
C07D51304
C07D41712

US Classification:

260239A

Abstract:

The invention relates to novel azetidinones of the general formula: ##STR1## wherein R stands for lower alkyl, phenyl, phenyloxyloweralkyl, phenylloweralkyl, 2-thiophenemethyl, 5-tetrazolylmethyl, R. sup. 3 O--and R. sup. 3 S--, wherein R. sup. 3 stands for lower alkyl, phenyl or phenylloweralkyl; R. sup. 1 is hydrogen or a cleavable radical selected from lower alkyl; loweralkoxymethyl, 2,2,2-trichloroethyl, benzyl, p-halobenzyl, p-nitrobenzyl and p-methoxybenzyl, benzhydryl and trimethylsilyl; R. sup. 2 is hydrogen or methoxy; X is SCl, Sbr or --OH in which case the C. sub. 3 -sidechain is better represented as the amide RCONH-- group; Y is chloro or bromo; and ##STR2## may also be taken as phthalimido. These novel compounds possess antibacterial activity and are useful intermediates for the synthesis of modified penicillins and the analogues of penicillins.

US Patent:

40910261, May 23, 1978

Filed:

Oct 15, 1975

Appl. No.:

5/622627

Inventors:

Ronald G. Micetich - Edmonton, CA
Clinton G. Chin - Edmonton, CA
Robert B. Morin - Warren NJ

Assignee:

Connlab Holdings Limited

International Classification:

C07D51304

US Classification:

2603067C

Abstract:

An improved process for preparing 4-thia-2,6-diazabicyclo[3,2,0]hept-2-ene-7-ones such as methyl 3-phenoxy-4-thia-2,6-diazabicyclo[3,2,0]hept-2-ene-7-one-6-isopropenylacet ate which comprises extruding sulfur from dithiazeneazetidinones such as methyl 3-phenoxymethyl-4,5-dithia-2,7-diazabicyclo[4,2,0]-oct-2-ene-8-one-7-isopr openylacetate. The compounds obtained are useful intermediates in the preparation of certain 3-cephems.

US Patent:

20180130551, May 10, 2018

Filed:

May 12, 2016

Appl. No.:

15/569302

Inventors:

- Basel, CH
Robert W. Morin - Boca Raton FL, US

International Classification:

G16H 20/17
G16H 50/20
A61M 5/172

Abstract:

A method of operating a glucose management device. The glucose management device includes one or more processing components, a housing, a user interface including a display and a user-input mechanism, and a memory. The method includes displaying on the display a prompt for initiating a carbohydrate factor determination sequence via the user-input mechanism and displaying on the display at least one query, the at least one query including a query associated with a user's type of diabetes. The method further includes receiving the user's response to the at least one query via the user-input mechanism and determining, via the at least one processing component, the carbohydrate factor using the user's response to the at least one query and information stored in the memory.

US Patent:

20160334385, Nov 17, 2016

Filed:

Dec 31, 2014

Appl. No.:

15/110739

Inventors:

- Basel, CH
Robert W. Morin - Boca Raton FL, US

International Classification:

G01N 33/49
G01N 33/487
G06T 11/20

Abstract:

Graphical representation of glycemic variation and average blood glucose values. The invention comprises storing in a memory a series of blood glucose values measured over a period of time; determining, using a processor, a variation value for the series of blood glucose values during the time period based on a standard deviation of the series of blood glucose values; plotting points using the processor for each of the blood glucose values around a center point where the radial distance from the center point to each point to be plotted is determined based on the variation value and a blood glucose value of the point to be plotted, and outputting to a display operative coupled to the processor, a graphical representation of the plotted series of blood glucose values and an indicia representative of the variation value.