Robert K Yu

US Patent:

6410597, Jun 25, 2002

Filed:

Feb 25, 2000

Appl. No.:

09/512597

Inventors:

Erhard Bieberich - Richmond VA
Raphael M. Ottenbrite - Midlothian VA
Robert K. Yu - Richmond VA
Helen Fillmore - Richmond VA
William C. Broaddus - Richmond VA

Assignee:

Virginia Commonwealth University - Richmond VA

International Classification:

A61K 3116

US Classification:

514625, 514613, 514627, 514629, 514630, 514727, 514730, 514738, 514739

Abstract:

The present invention provides methods for treating disease conditions associated with abnormal cellular proliferation, inflammation and viral infection or proliferation by the administration of ceramic analogs. The ceramic analogs appear to be specific for modulation of the enzyme PKC.

US Patent:

6436687, Aug 20, 2002

Filed:

Apr 21, 2000

Appl. No.:

09/556870

Inventors:

Robert K. Yu - Richmond VA
Chris Fronda - Richmond VA
Guichao Zeng - Richmond VA

Assignee:

Virginia Commonwealth University - Richmond VA

International Classification:

C12N 924

US Classification:

435200, 435 18, 435 691, 435325, 4352523, 4353201, 536 232

Abstract:

The present invention concerns mouse brain sialidase gene activity. The invention further relates to nucleic acids encoding sialidase protein, vectors containing and capable of expressing such nucleic acid, and recombinant host cells transformed with such nucleic acid. The invention also provides an amino acid sequence encoding an enzymatically active sialidase that is active in eukaryotic cells. The invention also provides host cells transfected or transformed with recombinant vectors expressing the sialidase gene from mouse brain in the host cells.

US Patent:

6280989, Aug 28, 2001

Filed:

Jun 17, 1999

Appl. No.:

9/334601

Inventors:

Dmitri Kapitonov - Philadelphia PA
Robert K. Yu - Richmond VA

International Classification:

C12N 910
C12N 1554

US Classification:

435193

Abstract:

The present invention relates to isolated sialyltransferases, such as human or mouse GM3 synthase, human or mouse 4ST3GalVI, or human 7STGalNAcV sialyltransferase polypeptide, biologically-active polypeptide fragments thereof, and nucleic acids which code for it. This polypeptide has various activities including sialyltransferase activity. The invention relates to all aspects of sialyltransferase, or homologs thereof, including assays for modulators, activators, ligands, etc. The invention also relates to sialyltransferases expressed in cells and methods of using such cells to engineer specific sugar chains.