Roger A Pedersen

US Patent:

61275980, Oct 3, 2000

Filed:

Jul 25, 1997

Appl. No.:

8/900510

Inventors:

Michael S. German - San Francisco CA
John L.R. Rubenstein - San Francisco CA
Lori Sussel - San Francisco CA
Maike Sander - San Francisco CA
Roger A. Pedersen - San Francisco CA
Juanito J. Meneses - San Francisco CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C12N 1509
C12N 1563
C12N 1500
C12N 500

US Classification:

800 18

Abstract:

The present invention features mouse models for Nkx-2. 2 gene function and for Nkx-6. 1 gene function, wherein the transgenic mouse is characterized by having a defect in Nkx-2. 2 gene function or a defect in Nkx-6. 1 gene function (where, because Nkx-2. 2 acts upstream of Nkx-6. 1, a defect in Nkx-2. 2 gene function affects Nkx-6. 1 gene function) and by having a decreased number of insulin-producing cells relative to a normal mouse. Where the transgenic mouse contains a defect in Nkx-2. 2 gene function, the mouse is further characterized by a decreased number of serotonin-producing cells relative to a normal mouse. The transgenic mice may be either homozygous or heterozygous for the Nkx-2. 2 or Nkx-6. 1 defect.