Ronald W Cook

US Patent:

44749481, Oct 2, 1984

Filed:

Apr 8, 1982

Appl. No.:

6/366538

Inventors:

Derek Hudson - San Rafael CA
Ronald M. Cook - San Rafael CA

Assignee:

Biosearch - San Rafael CA

International Classification:

C07H 1918
C07H 1920

US Classification:

536 27

Abstract:

Benzotriazoles are employed in phosphite triester oligonucleotide synthesis. The benzotriazoles also form phosphinedibenzazolides. Processes employing these reagents are also disclosed.

US Patent:

41628144, Jul 31, 1979

Filed:

Jul 17, 1978

Appl. No.:

5/924913

Inventors:

James J. Garbero - Carmichael CA
Ronald F. Cook - Pendleton OR

International Classification:

A47B 7700

US Classification:

312223

Abstract:

This application relates to a lighted display chamber for momentos, gimcracks, trophies and the like, and preferably translucent or transparent ones since the device of this invention includes a blinking light means to transmit light from the base through the display object. The blinking light is actuated by a predetermined positioning of the top of the display chamber.

US Patent:

56795394, Oct 21, 1997

Filed:

Jan 24, 1995

Appl. No.:

8/377808

Inventors:

Derek Hudson - San Anselmo CA
Ronald M. Cook - Novato CA

International Classification:

C12P 2106
C12N 1106
G01N 33549
C07K 1706

US Classification:

435 681

Abstract:

Polyolefin particles are chemically modified by oxidation to provide a large surface area and high loading. The particles result in low back pressure in column systems, and are economical to manufacture. The particles are useful as supports in a wide range of applications including general organic as well as biopolymer synthesis, library methods, purification processes and enzyme mediated processes. In a preferred embodiment, polyethylene or polypropylene particles are oxidized in a solution containing trifluoroacetic acid or trifluoromethane sulfonic acid, chromium trioxide and sulfuric acid to provide the particles with a chemically reactive irregular surface and open channels that extend below the surface and up to essentially the length of the radius of the particles resulting in increased surface area and decreased density. The particles have pendant functional groups produced by the oxidation and/or by subsequent chemical reaction. The pendant functional groups may be attached to spacer arms that are attached to the surface of the particles.

US Patent:

51476088, Sep 15, 1992

Filed:

Apr 29, 1988

Appl. No.:

7/188453

Inventors:

Derek Hudson - San Anselmo CA
Jordan Honig - San Francisco CA
Ronald M. Cook - Ross CA
Douglas J. Ng - El Cerrito CA

Assignee:

Millipore Corporation - Bedford MA

International Classification:

G01N 3368

US Classification:

422 63

Abstract:

A chemical processing system is disclosed for the automated dissolution, dispersing and reaction of chemicals, especially for synthesizing proteins. The system includes a plurality of storage cartridges containing a first chemical in fluid communication with a reservoir containing a second chemical to be reacted with the first chemical. Each cartridge includes a pump (e. g. , a plunger) which operates by changing the internal volume of the cartridge. The pump permits bi-directional flow of the first chemical into and out of the reservoir and cartridge to promote mixing and reacting with the second chemical in the reservoir to produce a third chemical.

US Patent:

44749473, Oct 2, 1984

Filed:

Apr 8, 1982

Appl. No.:

6/366537

Inventors:

Derek Hudson - San Rafael CA
Ronald M. Cook - San Rafael CA

Assignee:

Biosearch - San Rafael CA

International Classification:

C07H 1910

US Classification:

536 27

Abstract:

Benzazoles, including benzatriazoles and benzimidazoles are employed in phospate triester oligonucleotide synthesis. The benzazoles form arylbenzazolide coupling agents, and phosphorodibenzazolides. Processes employing these reagents are also disclosed.

US Patent:

20140323325, Oct 30, 2014

Filed:

Mar 4, 2014

Appl. No.:

13/999508

Inventors:

Marc Beal - Concord CA, US
Ronald M. Cook - Novato CA, US
Peter Jay Coassin - Encinitas CA, US
Arturo Orjalo - Oakland CA, US
Jekwan Ryu - Cupertino CA, US

International Classification:

C12Q 1/68
G01N 21/64

US Classification:

506 9, 436501, 435 611, 435 5

Abstract:

The present invention generally relates to imaging single molecules, or one or more collections of single molecules, and methods related to the imaging. In a method aspect, the present invention provides a method of imaging single molecules. The method comprises the steps of: a) exposing a test sample to a probe, wherein the probe comprises a first portion that specifically binds to a target molecule and a second portion that is detectable as the result of one or more chemical groups that interact with light at one or more wavelengths, wherein the probe binds to a target molecule to provide a complex; b) exposing the complex to one or more wavelengths of light that interact with the one or more chemical groups; c) detecting a result from the interacting of one or more wavelengths of light that interact with the one or more chemical groups to provide an image of one or more single molecules. The image possesses a resolution better than 450 nm over a view field area of at least 1×10μm, and wherein the image is obtained in a single detection step without variation of any detection settings.