Ronald W Thomas

US Patent:

58373128, Nov 17, 1998

Filed:

Sep 20, 1996

Appl. No.:

8/717004

Inventors:

Christopher T. Cordle - Centerburg OH
Lynn P. Nelles - Westerville OH
Ronald L. Thomas - Clemson SC

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A23L 100
A23P 100
A23J 100
C07C22700

US Classification:

426656

Abstract:

A method for debittering and reducing the allergenic reactivity of protein hydrolysates is disclosed, which method includes the providing of an aqueous solution of a protein hydrolysate, feeding the solution into a bed of siloxane, and collecting a first portion of the solution exiting from the bed. The first portion contains either a non-bitter or bitter fraction. A second portion of the solution exiting from the bed can be collected which contains the opposite tasting fraction of the hydrolysate. Preferably the siloxane is selected from the group comprising octa-siloxane and octadecyl-siloxane. Preferably the hydrolysate has a molecular weight of less than 10,000, and is derived from the group of hydrolysates comprising casein, whey and soy. Additionally, the bed preferably is of a depth of between 2 to 4 times the bed diameter. A more hypoallergenic protein hydrolysate product produced in accordance with the method of the invention is also disclosed.

US Patent:

48974650, Jan 30, 1990

Filed:

Oct 12, 1988

Appl. No.:

7/256813

Inventors:

Christopher T. Cordle - Centerburg OH
Larry G. Criswell - Columbus OH
Ronald L. Thomas - Clemson SC

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07K 326
C07K 1514
B07C 518

US Classification:

530387

Abstract:

Disclosed are ultrafiltration processes for the enrichment and concentration of selected proteins from protein conaining fluids. Illustratively, IgG is concentrated from whey by means of multiple ultrafiltration "passes", using a metallic oxide ultrafiltration membrane, which are characterized by differing pH's.