Ronald John Wysocki

US Patent:

20120291667, Nov 22, 2012

Filed:

Apr 16, 2012

Appl. No.:

13/448325

Inventors:

Charles Geoffrion - Tucson AZ, US
Craig Grossman - Point Roberts WA, US
Mai Ngo - Tucson AZ, US
Ronald Wysocki - Tucson AZ, US

International Classification:

C09D 7/00
B05D 1/36

US Classification:

10628719, 4274195, 427470

Abstract:

A method to prepare a self-decontaminating surface, where that method includes disposing a first coating on a surface, where that first coating comprises an organosilane, and disposing a second coating over the first coating, where the second coating comprises TiO.

US Patent:

58177990, Oct 6, 1998

Filed:

Jul 23, 1990

Appl. No.:

7/556713

Inventors:

Victor E. Marquez - Bethesda MD
John S. Driscoll - Rockville MD
Ronald J. Wysocki - Potomac MD
Magbool A. Siddiqui - Gaithersburg MD

Assignee:

The United States of America as represented by the Department of Health
and Human Services - Washington DC

International Classification:

C07H 100

US Classification:

536 282

Abstract:

A method of preparing a 2'-fluoro compound of the formula ##STR1## where B is selected from the group consisting of purines and pyrimidines, both of which may be substituted, comprises reacting a compound of the formula II(a) or II(b) ##STR2## where R and R' are as defined in the specification with an acid halide under conditions effective to obtain a halide of the formula ##STR3## where X is a halogen. A silane of the formula B-Si (R"). sub. 3 where R" is as defined in the specification, is added to this product (III) under conditions effective to obtain a compound of the formula (IV) ##STR4## The compound of formula (IV) is reacted with a reagent selected from the group consisting of ammonia, BCl. sub. 3 and ((C. sub. 1 -C. sub. 10)alkyl). sub. 4 NF, under conditions effective to obtain the compound of formula (I). The compounds of formula (I) resulting from these methods exhibit anti-HIV activities and are useful for therapy against the HIV virus.

US Patent:

56705018, Sep 23, 1997

Filed:

Sep 1, 1994

Appl. No.:

8/299992

Inventors:

James V. Peck - Richmond VA
Ronald J. Wysocki - Richmond VA
Ibrahim M. Uwaydah - Richmond VA
Noel J. Cusack - Richmond VA

Assignee:

Discovery Therapeutics, Inc. - Richmond VA

International Classification:

C07D47334
C07D31772
A61K 3152
A61K 31535

US Classification:

5142342

Abstract:

Optically active or racemic compounds represented by the formula ##STR1## where R. sub. 1 is C. sub. 1 to C. sub. 4 straight chain or branched alkyl; R. sub. 2 is selected from the group consisting of H, --OR. sub. 1, --SR. sub. 1, --NH(R. sub. 1), --N(R. sub. 4)(R. sub. 5), aminocarbonyl, halogen, and --CN, where R. sub. 4 and R. sub. 5 are independently C. sub. 1 to C. sub. 6 straight chain or branched alkyl, or taken together form a 3- to 7-membered heterocycloalkyl substituent, such heteroatom selected from the group consisting of oxygen, nitrogen and sulfur, optionally including an additional heteroatom which is selected from the group consisting of nitrogen, oxygen, and sulfur; R. sub. 3 is cyclopentyl or: ##STR2## where R' and R" are independently H,. dbd. O, --OH, or --NH. sub.

US Patent:

53367642, Aug 9, 1994

Filed:

Oct 29, 1992

Appl. No.:

7/968567

Inventors:

Victor E. Marquez - Bethesda MD
John S. Driscoll - Rockville MD
Ronald J. Wysocki - Potomac MD
Maqbool A. Siddiqui - Gaithersburg MD

Assignee:

The United States of America as represented by the Department of Health
and Human Services - Washington DC

International Classification:

C07G 300

US Classification:

536 41

Abstract:

A compound has the formula ##STR1## wherein R is selected from the group consisting of (C. sub. 7 -C. sub. 20)aroyl, (C. sub. 6 -C. sub. 20)aryl, aralkyl and alkylaryl, and (C. sub. 1 -C. sub. 10)alkyl-di(C. sub. 6 -C. sub. 20)aryl Si, R' is selected from the group consisting of (C. sub. 1 -C. sub. 10)alkyl, (C. sub. 7 -C. sub. 20)aroyl and (C. sub. 2 -C. sub. 12)acyl, all of which may be further substituted with O, S, N or alkyl, and R'" is selected from the group consisting of halogen, (C. sub. 1 -C. sub. 10)alkoxy, (C. sub. 1 -C. sub. 10)acyloxy, O-methane-sulfonyl and O-p-toluenesulfonyl. A composition of matter comprises 0. 001 to 99. 999 wt % of the above compound.

US Patent:

59815248, Nov 9, 1999

Filed:

Aug 4, 1997

Appl. No.:

8/904553

Inventors:

James V. Peck - Richmond VA
Ronald J. Wysocki - Richmond VA
Ibrahim M. Uwaydah - Richmond VA
Noel J. Cusack - Richmond VA

Assignee:

Discovery Therapeutics, Inc. - Richmond VA

International Classification:

C07D47334
C07D31772
A61K 3152
A61K 31535

US Classification:

5142342

Abstract:

Optically active or racemic compounds represented by the formula ##STR1## where R. sub. 1 is C. sub. 1 to C. sub. 4 straight chain or branched alkyl; R. sub. 2 is selected from the group consisting of H, --OR. sub. 1, --SR. sub. 1, --NH(R. sub. 1), --N(R. sub. 4)(R. sub. 5), aminocarbonyl, halogen, and --CN, where R. sub. 4 and R. sub. 5 are independently C. sub. 1 to C. sub. 6 straight chain or branched alkyl, or taken together form a 3- to 7-membered heterocycloalkyl substituent, such heteroatom selected from the group consisting of oxygen, nitrogen and sulfur, optionally including an additional heteroatom which is selected from the group consisting of nitrogen, oxygen, and sulfur; R. sub. 3 is cyclopentyl or: ##STR2## where R' and R" are independently H,. dbd. O, --OH, or --NH. sub.

US Patent:

20170157640, Jun 8, 2017

Filed:

Feb 14, 2017

Appl. No.:

15/432334

Inventors:

- Dallas TX, US
Mai Ngo - Tucson AZ, US
Ronald Wysocki - Tucson AZ, US

Assignee:

Allied Bioscience, Inc. - Dallas TX

International Classification:

B05D 1/04
D06M 15/423
D06M 13/513
D06M 23/00
D06M 11/46

Abstract:

A method to prepare a self-decontaminating surface, where that method includes disposing a first coating on a surface, where that first coating comprises an organosilane, and disposing a second coating over the first coating, where the second coating comprises TiO.

US Patent:

20170158825, Jun 8, 2017

Filed:

Feb 14, 2017

Appl. No.:

15/432363

Inventors:

- Dallas TX, US
Mai Ngo - Tucson AZ, US
Ronald Wysocki - Tucson AZ, US

Assignee:

Allied Bioscience, Inc. - Dallas TX

International Classification:

C08G 79/00
C09D 183/08
C08G 77/26
C09D 185/00
C09D 5/00
C07F 7/28

Abstract:

A method to prepare a self-decontaminating surface, where that method includes disposing a first coating on a surface, where that first coating comprises an organosilane, and disposing a second coating over the first coating, where the second coating comprises TiO.

US Patent:

20170158873, Jun 8, 2017

Filed:

Feb 14, 2017

Appl. No.:

15/432352

Inventors:

- Dallas TX, US
Mai Ngo - Tucson AZ, US
Ronald Wysocki - Tucson AZ, US

Assignee:

Allied Bioscience, Inc. - Dallas TX

International Classification:

C09D 5/14
A01N 55/02
A01N 55/00
C09D 7/12
C09D 185/00

Abstract:

A method to prepare a self-decontaminating surface, where that method includes disposing a first coating on a surface, where that first coating comprises an organosilane, and disposing a second coating over the first coating, where the second coating comprises TiO.