Sandra T Knowles

US Patent:

8551984, Oct 8, 2013

Filed:

Dec 15, 2010

Appl. No.:

12/968608

Inventors:

Michael D. Altman - Needham MA, US
Brian M. Andresen - Sharon MA, US
Kenneth L. Arrington - Revere MA, US
Jason Burch - Westmount, CA
Kaleen Konrad Childers - Newton MA, US
Bernard Cote - Notre-Dame-de-l'lle-Perrot, CA
Maria Emilia Di Francesco - Brookline MA, US
Anthony Donofrio - Cambridge MA, US
Kristina Dupont-Gaudet - Vaudreuil-Dorion, CA
John Michael Ellis - Needham MA, US
Christian Fischer - Natick MA, US
Daniel Guay - Lachine, CA
David Joseph Guerin - Natick MA, US
Andrew M. Haidle - Cambridge MA, US
Solomon Kattar - Arlington MA, US
Sandra Lee Knowles - Boston MA, US
Chaomin Li - Boston MA, US
Jongwon Lim - Lexington MA, US
Michelle R. Machacek - Brookline MA, US
Alan B. Northrup - Reading MA, US
Brendan M. O'Boyle - Boston MA, US
Ryan D. Otte - Natick MA, US
Michael H. Reutershan - Brookline MA, US
Eric Romeo - Alliston MA, US
Adam J. Schell - Newton MA, US
Tony Siu - Brookline MA, US
Kerrie B. Spencer - Woonsocket RI, US
Brandon M. Taoka - Brookline MA, US
B. Wesley Trotter - Newton Highland MA, US
Hua Zhou - Acton MA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ
Merck Canada Inc. - Kirkland, Quebec

International Classification:

C07D 417/12
A61K 31/497

US Classification:

51421208, 51421706, 5142358, 51425202, 51425219, 514275, 540524, 540601, 544122, 544238, 544295, 544296, 544331

Abstract:

The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.

US Patent:

20110195933, Aug 11, 2011

Filed:

Jul 27, 2009

Appl. No.:

13/057510

Inventors:

Jason D. Katz - Newton Highlands MA, US
Sandra L. Knowles - Cambridge MA, US
James P. Jewell - Sandwich MA, US
David L. Sloman - Boston MA, US
Matthew G. Stanton - Marlton NJ, US

International Classification:

A61K 31/675
C07D 471/04
A61K 31/437
A61K 31/496
C07D 413/14
A61K 31/5377
C07D 471/10
A61K 31/438
A61K 31/397
C07F 9/576
A61K 31/5513
A61P 25/28

US Classification:

514 80, 546121, 514300, 544362, 51425304, 544127, 5142332, 546 18, 514278, 51421021, 546 21, 540569, 514221

Abstract:

The invention encompasses pyrazolo[1,5-a]pyridine derivatives which selectively inhibit microtubule affinity regulating kinase (MARK) and are therefore useful for the treatment or prevention of Alzheimer's disease. Pharmaceutical compositions and methods of use are also included.

US Patent:

20120277192, Nov 1, 2012

Filed:

Dec 15, 2010

Appl. No.:

13/516455

Inventors:

Michael D. Altman - Needham MA, US
Brian M. Andresen - Sharon MA, US
Kenneth L. Arrington - Revere MA, US
Sathesh Bhat - Dollard-des-Ormeaux, CA
Jason Burch - Redwood City CA, US
Kaleen Konrad Childers - Newton MA, US
Bernard Cote - Notre-Dame-de-I'Ile-Perrot, CA
Maria Emilia Di Francesco - Houston TX, US
Anthony Donofrio - Cambridge MA, US
Kristina Dupont-Gaudet - Vaudreuil-Dorion, CA
John Michael Ellis - Needham MA, US
Christian Fischer - Natick MA, US
Jean-Francois Fournier - Montreal, CA
Jacques Yves Gauthier - Laval, CA
Jonathan Grimm - Asburn VA, US
Daniel Guay - Lachine, CA
David Joseph Guerin - Natick MA, US
Andrew M. Haidle - Cambridge MA, US
Solomon Kattar - Arlington MA, US
Sandra Lee Knowles - Princeton NJ, US
Chaomin Li - Boston MA, US
Jongwon Lim - Lexintong MA, US
Michelle R. Machacek - Brookline MA, US
Matthew L. Maddess - Boston MA, US
Alan B. Northrup - Reading MA, US
Brendan M. O'Boyle - Boston MA, US
Ryan D. Otte - Natick MA, US
Alessia Petrocchi - Houston TX, US
Michael H. Reutershan - Brookline MA, US
Joel S. Robichaud - Dollar-des-Ormeaux, CA
Eric Romeo - Allston MA, US
Adam J. Schell - Decatur GA, US
Tony Siu - Brookline MA, US
Kerrie B. Spencer - Woonsocket RI, US
Brandon M. Taoka - Hoboken NJ, US
B. Wesley Trotter - Newton Highlands MA, US
Hyun Chong Woo - Natick MA, US
Hua Zhou - Acton MA, US

International Classification:

A61K 31/506
A61K 31/55
A61K 31/554
A61K 31/551
A61P 35/00
C07D 417/14
C07F 9/6539
C07D 417/12
A61P 19/02
A61P 11/06
A61K 31/675
A61K 31/5377

US Classification:

514 86, 5142102, 51421202, 51421208, 514218, 5142358, 514249, 514275, 540488, 540492, 540524, 544123, 544243, 544321

Abstract:

The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.

US Patent:

20120309735, Dec 6, 2012

Filed:

Dec 16, 2010

Appl. No.:

13/515941

Inventors:

Michael D. Altman - Needham MA, US
Kenneth L. Arrington - Revere MA, US
Jason Burch - Redwood City CA, US
Bernard Cote - Notre-Dame-de-I'lle-Perrot, CA
Jean-Francois Fournier - Juan les Pins, FR
Jacques Yves Gauthier - Laval des Rapides, CA
Solomon Kattar - Arlington MA, US
Sandra Lee Knowles - Princeton NJ, US
Jongwon Lim - Lexington MA, US
Michelle R. Machacek - Brookline MA, US
Alan B. Northrup - Reading MA, US
Michael H. Reutershan - Brookline MA, US
Joel S. Robichaud - Dollard des Ormeaux, CA
Adam J. Schell - Decatur GA, US
Kerrie B. Spencer - Woonsocket RI, US

International Classification:

A61K 31/506
C07D 417/12
C07D 417/14
C07D 471/04
A61P 19/02
A61K 31/551
A61P 11/06
A61P 11/00
A61P 29/00
C07D 471/10
A61K 31/5377

US Classification:

5142102, 544230, 514275, 544331, 544296, 544295, 51425505, 544122, 5142358, 51425219, 540492, 514218, 514249, 540575

Abstract:

The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.

US Patent:

20140243290, Aug 28, 2014

Filed:

Apr 17, 2014

Appl. No.:

14/255480

Inventors:

Michael D. Altman - Needham MA, US
Brian M. Andresen - Sharon MA, US
Kenneth L. Arrington - Lansdale PA, US
Sathesh Bhat - Jersey City NJ, US
Jason Burch - Redwood City CA, US
Kaleen Konrad Childers - Medfield MA, US
Bernard Cote - Notre-Dame-de-I'll-Perrot, CA
Maria Emilia Di Francesco - Houston TX, US
Anthony Donofrio - Cambridge MA, US
Kristina Dupont-Gaudet - Vaudreuil-Dorion, CA
John Michael Ellis - Needham MA, US
Christian Fischer - Natick MA, US
Jean-Francois Fournier - Juan Les Pins, FR
Jacques Yves Gauthier - Laval, CA
Jonathan Grimm - Ashburn VA, US
Daniel Guay - Lachine, CA
David Joseph Guerin - Natick MA, US
Andrew M. Haidle - Cambridge MA, US
Solomon D. Kattar - Arlington MA, US
Sandra Lee Knowles - Princeton NJ, US
Chaomin Li - Boston MA, US
Jongwon Lim - Lexington MA, US
Michelle R. Machacek - Brookline MA, US
Matthew L. Maddess - Boston MA, US
Alan B. Northrup - Reading MA, US
Brendan M. O'Boyle - Boston MA, US
Ryan D. Otte - Natick MA, US
Alessia Petrocchi - Houston TX, US
Michael H. Reutershan - Brighton MA, US
Joel S. Robichaud - Dollard-des-Ormeaux, CA
Eric T. Romeo - Allston MA, US
Adam J. Schell - Decatur GA, US
Tony Siu - Brookline MA, US
Kerrie B. Spencer - Woonsocket RI, US
Brandon M. Taoka - Hoboken NJ, US
B. Wesley Trotter - Newton Highlands MA, US
Hyun Chong Woo - Natick MA, US
Hua Zhou - Acton MA, US

International Classification:

C07D 417/12
C07D 495/04
C07D 451/06
C07F 9/6558
C07D 471/08
C07D 487/04
C07D 471/04
C07D 417/14
C07D 491/08

US Classification:

514 86, 544331, 514275, 544230, 540524, 51421208, 544122, 5142358, 51425219, 51421018, 5142102, 540601, 51421706, 544296, 540544, 51421115

Abstract:

The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.

US Patent:

20140243337, Aug 28, 2014

Filed:

Oct 1, 2012

Appl. No.:

14/349558

Inventors:

Michael D. Altman - Needham MA, US
Maria Emilia Di Francesco - Houston TX, US
John Michael Ellis - Needham MA, US
Sandra Lee Knowles - Princeton NJ, US
Alan B. Northrup - Reading MA, US

International Classification:

C07D 213/74
C07D 401/04
A61K 31/47
A61K 31/5377
A61K 31/444
A61K 31/435
A61K 31/4439

US Classification:

5142355, 546297, 514349, 5462754, 514341, 544131, 546257, 514334, 546161, 514313, 5462764, 514343, 546309, 514352

Abstract:

The invention provides certain phenyl carboxamide-containing compounds of the Formula (I); or pharmaceutically acceptable salts thereof, wherein A and B are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.