Sandra L Knowles

US Patent:

8551984, Oct 8, 2013

Filed:

Dec 15, 2010

Appl. No.:

12/968608

Inventors:

Michael D. Altman - Needham MA, US
Brian M. Andresen - Sharon MA, US
Kenneth L. Arrington - Revere MA, US
Jason Burch - Westmount, CA
Kaleen Konrad Childers - Newton MA, US
Bernard Cote - Notre-Dame-de-l'lle-Perrot, CA
Maria Emilia Di Francesco - Brookline MA, US
Anthony Donofrio - Cambridge MA, US
Kristina Dupont-Gaudet - Vaudreuil-Dorion, CA
John Michael Ellis - Needham MA, US
Christian Fischer - Natick MA, US
Daniel Guay - Lachine, CA
David Joseph Guerin - Natick MA, US
Andrew M. Haidle - Cambridge MA, US
Solomon Kattar - Arlington MA, US
Sandra Lee Knowles - Boston MA, US
Chaomin Li - Boston MA, US
Jongwon Lim - Lexington MA, US
Michelle R. Machacek - Brookline MA, US
Alan B. Northrup - Reading MA, US
Brendan M. O'Boyle - Boston MA, US
Ryan D. Otte - Natick MA, US
Michael H. Reutershan - Brookline MA, US
Eric Romeo - Alliston MA, US
Adam J. Schell - Newton MA, US
Tony Siu - Brookline MA, US
Kerrie B. Spencer - Woonsocket RI, US
Brandon M. Taoka - Brookline MA, US
B. Wesley Trotter - Newton Highland MA, US
Hua Zhou - Acton MA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ
Merck Canada Inc. - Kirkland, Quebec

International Classification:

C07D 417/12
A61K 31/497

US Classification:

51421208, 51421706, 5142358, 51425202, 51425219, 514275, 540524, 540601, 544122, 544238, 544295, 544296, 544331

Abstract:

The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.

US Patent:

20110195933, Aug 11, 2011

Filed:

Jul 27, 2009

Appl. No.:

13/057510

Inventors:

Jason D. Katz - Newton Highlands MA, US
Sandra L. Knowles - Cambridge MA, US
James P. Jewell - Sandwich MA, US
David L. Sloman - Boston MA, US
Matthew G. Stanton - Marlton NJ, US

International Classification:

A61K 31/675
C07D 471/04
A61K 31/437
A61K 31/496
C07D 413/14
A61K 31/5377
C07D 471/10
A61K 31/438
A61K 31/397
C07F 9/576
A61K 31/5513
A61P 25/28

US Classification:

514 80, 546121, 514300, 544362, 51425304, 544127, 5142332, 546 18, 514278, 51421021, 546 21, 540569, 514221

Abstract:

The invention encompasses pyrazolo[1,5-a]pyridine derivatives which selectively inhibit microtubule affinity regulating kinase (MARK) and are therefore useful for the treatment or prevention of Alzheimer's disease. Pharmaceutical compositions and methods of use are also included.

US Patent:

20120277192, Nov 1, 2012

Filed:

Dec 15, 2010

Appl. No.:

13/516455

Inventors:

Michael D. Altman - Needham MA, US
Brian M. Andresen - Sharon MA, US
Kenneth L. Arrington - Revere MA, US
Sathesh Bhat - Dollard-des-Ormeaux, CA
Jason Burch - Redwood City CA, US
Kaleen Konrad Childers - Newton MA, US
Bernard Cote - Notre-Dame-de-I'Ile-Perrot, CA
Maria Emilia Di Francesco - Houston TX, US
Anthony Donofrio - Cambridge MA, US
Kristina Dupont-Gaudet - Vaudreuil-Dorion, CA
John Michael Ellis - Needham MA, US
Christian Fischer - Natick MA, US
Jean-Francois Fournier - Montreal, CA
Jacques Yves Gauthier - Laval, CA
Jonathan Grimm - Asburn VA, US
Daniel Guay - Lachine, CA
David Joseph Guerin - Natick MA, US
Andrew M. Haidle - Cambridge MA, US
Solomon Kattar - Arlington MA, US
Sandra Lee Knowles - Princeton NJ, US
Chaomin Li - Boston MA, US
Jongwon Lim - Lexintong MA, US
Michelle R. Machacek - Brookline MA, US
Matthew L. Maddess - Boston MA, US
Alan B. Northrup - Reading MA, US
Brendan M. O'Boyle - Boston MA, US
Ryan D. Otte - Natick MA, US
Alessia Petrocchi - Houston TX, US
Michael H. Reutershan - Brookline MA, US
Joel S. Robichaud - Dollar-des-Ormeaux, CA
Eric Romeo - Allston MA, US
Adam J. Schell - Decatur GA, US
Tony Siu - Brookline MA, US
Kerrie B. Spencer - Woonsocket RI, US
Brandon M. Taoka - Hoboken NJ, US
B. Wesley Trotter - Newton Highlands MA, US
Hyun Chong Woo - Natick MA, US
Hua Zhou - Acton MA, US

International Classification:

A61K 31/506
A61K 31/55
A61K 31/554
A61K 31/551
A61P 35/00
C07D 417/14
C07F 9/6539
C07D 417/12
A61P 19/02
A61P 11/06
A61K 31/675
A61K 31/5377

US Classification:

514 86, 5142102, 51421202, 51421208, 514218, 5142358, 514249, 514275, 540488, 540492, 540524, 544123, 544243, 544321

Abstract:

The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.

US Patent:

20120309735, Dec 6, 2012

Filed:

Dec 16, 2010

Appl. No.:

13/515941

Inventors:

Michael D. Altman - Needham MA, US
Kenneth L. Arrington - Revere MA, US
Jason Burch - Redwood City CA, US
Bernard Cote - Notre-Dame-de-I'lle-Perrot, CA
Jean-Francois Fournier - Juan les Pins, FR
Jacques Yves Gauthier - Laval des Rapides, CA
Solomon Kattar - Arlington MA, US
Sandra Lee Knowles - Princeton NJ, US
Jongwon Lim - Lexington MA, US
Michelle R. Machacek - Brookline MA, US
Alan B. Northrup - Reading MA, US
Michael H. Reutershan - Brookline MA, US
Joel S. Robichaud - Dollard des Ormeaux, CA
Adam J. Schell - Decatur GA, US
Kerrie B. Spencer - Woonsocket RI, US

International Classification:

A61K 31/506
C07D 417/12
C07D 417/14
C07D 471/04
A61P 19/02
A61K 31/551
A61P 11/06
A61P 11/00
A61P 29/00
C07D 471/10
A61K 31/5377

US Classification:

5142102, 544230, 514275, 544331, 544296, 544295, 51425505, 544122, 5142358, 51425219, 540492, 514218, 514249, 540575

Abstract:

The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.

US Patent:

20210380580, Dec 9, 2021

Filed:

Jun 22, 2018

Appl. No.:

16/621953

Inventors:

- Rahway NJ, US
- SHANGHAI, CN
Qiaolin DENG - Princeton NJ, US
Melissa EGBERTSON - Ambler PA, US
Ronald FERGUSON, II - Scotch Plains NJ, US
Xiaolei GAO - Bridgewater NJ, US
Scott Timothy HARRISON - Elkins Park PA, US
Timothy J. HENDERSON - Natick MA, US
Sandra L. KNOWLES - Princeton NJ, US
Chunsing LI - Shanghai, CN
Michael Man-Chu LO - Bedminster NJ, US
Meng NA - Shanghai, CN
Michael T. RUDD - Collegeville PA, US
Oleg B. Selyutin - West Windsor NJ, US
David M. TELLERS - Lansdale PA, US
Ling TONG - Warren NJ, US
Fengqi ZHANG - Edison NJ, US
Takao SUZUKI - Shanghai, CN

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ
MSD R&D (CHINA) CO., LTD. - SHANGHAI

International Classification:

C07D 471/04
C07D 401/14
C07D 417/14
C07D 413/14
C07D 487/04
C07D 405/14

Abstract:

The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

US Patent:

20200207758, Jul 2, 2020

Filed:

Jun 22, 2018

Appl. No.:

16/621959

Inventors:

Jianming BAO - San Mateo CA, US
Qiaolin DENG - Princeton NJ, US
Melissa EGBERTSON - Ambler PA, US
Ronald FERGUSON, II - Scotch Plains NJ, US
Xiaolei GAO - Bridgewater NJ, US
Scott Timothy HARRISON - Elkins Park PA, US
Sandra L. KNOWLES - Princeton NJ, US
Chunsing LI - Shanghai, CN
Michael Man-Chu LO - Bedminster NJ, US
Zhaoyang MENG - Ambler PA, US
Meng NA - Shanghai, CN
Michael T. RUDD - Collegeville PA, US
Oleg SELYUTIN - West Windsor NJ, US
David M. TELLERS - Lansdale PA, US
Ling TONG - Warren NJ, US
Fengqi ZHANG - Edison NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 471/04
C07D 401/14
C07D 401/04
C07D 413/14
C07D 405/14
C07D 491/048
C07D 498/04

Abstract:

The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

US Patent:

20200095261, Mar 26, 2020

Filed:

Dec 18, 2017

Appl. No.:

16/471672

Inventors:

- Rahway NJ, US
Sandra L. KNOWLES - Princeton NJ, US
Chunsing LI - Shanghai, CN
Michael Man-Chu LO - Bedminster NJ, US
Debra L. ONDEYKA - Fanwood NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 498/14
C07D 487/04
C07D 471/04
C07D 513/04
C07D 401/14
C07D 491/048

Abstract:

The present invention is directed to 6,5-fused heteroarylpiperidine ether compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

US Patent:

20200069671, Mar 5, 2020

Filed:

Nov 5, 2019

Appl. No.:

16/674546

Inventors:

- Rahway NJ, US
Jianming Bao - South San Francisco CA, US
Melissa Egbertson - Ambler PA, US
Xiaolei Gao - Bridgewater NJ, US
Scott T. Harrison - Elkins Park PA, US
Sandra L. Knowles - Princeton NJ, US
Chunsing Li - Shanghai, CN
Michael Man-Chu Lo - Bedminster NJ, US
Zhaoyang Meng - Ambler PA, US
Michael T. Rudd - Collegeville PA, US
Oleg B. Selyutin - West Windsor NJ, US
David M. Tellers - Lansdale PA, US
Ling Tong - Warren NJ, US
Jenny Miu-Chun Wai - Harleysville PA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ
MSD R & D (China) Co., Ltd. - Shanghai

International Classification:

A61K 31/4439
A61P 25/28
A61P 25/18
A61P 25/16
A61K 31/437
C07D 401/14
C07D 405/14
C07D 471/04

Abstract:

The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.