Sandra L Sims

US Patent:

6796975, Sep 28, 2004

Filed:

Mar 15, 2001

Appl. No.:

09/809695

Inventors:

Sandra M. Sims - Portage MI
Phil Bryan Bowman - Kalamazoo MI
Daniel C. Wade - Portage MI
Shri C. Valvani - Kalamazoo MI

Assignee:

Pharmacia Upjohn Company - Kalamazoo MI

International Classification:

A61B 1900

US Classification:

604403

Abstract:

The present invention is a container for an IV aqueous solution of a Gram-positive oxazolidinone agent, such as linezolid a the compound of formula: which comprises having the container-solution contact surface material be a polyolefin.

US Patent:

6989381, Jan 24, 2006

Filed:

Aug 20, 2001

Appl. No.:

09/933366

Inventors:

Sandra M. Sims - Portage MI, US

Assignee:

Pharmacia Corporation - St. Louis MO

International Classification:

A61K 31/535

US Classification:

5142355, 5142368

Abstract:

There is provided a pharmaceutical composition for therapeutic or prophylactic administration to a subject having an infective disease or condition or at risk thereof. The composition comprises an aqueous carrier having in solution therein (a) an oxazolidinone antimicrobial drug, for example linezolid, in a therapeutically or prophylactically effective drug concentration that is above the practical limit of solubility of the drug in a substantially isotonic aqueous solution at a physiologically compatible pH, and (b) a pharmaceutically acceptable cyclodextrin compound in a concentration sufficient to maintain the drug in solution at such a drug concentration. The composition is particularly useful for intravenous delivery of the drug.

US Patent:

20030027790, Feb 6, 2003

Filed:

Feb 22, 2002

Appl. No.:

10/080810

Inventors:

Satish Singh - Portage MI, US
Lisa Adams - Mattawan MI, US
Paramita Bandyopadhyay - Portage MI, US
Syed Hasan - Portage MI, US
Leslie Hawley - Kalamazoo MI, US
Sandra Sims - Portage MI, US

International Classification:

A61K031/724
A61K031/553
A61K031/554
A61K031/541
A61K031/5377
A61K031/427
A61K031/42

US Classification:

514/058000, 514/211150, 514/227800, 514/236800, 514/365000, 514/376000

Abstract:

There is provided a pharmaceutical preservative free composition suitable for topical administration to an eye, the composition comprising (a) an oxazolidinone antimicrobial drug, for example linezolid, in a therapeutically or prophylactically effective drug concentration that is above the practical limit of solubility of the drug in a substantially isotonic aqueous solution at a physiologically compatible pH, and (b) a pharmaceutically acceptable cyclodextrin compound in a concentration sufficient to maintain the drug-in solution at such a drug concentration. The composition is particularly useful for the treatment and/or prevention of eye infections due to gram positive bacteria.

US Patent:

20050075619, Apr 7, 2005

Filed:

Mar 26, 2003

Appl. No.:

10/397781

Inventors:

Sandra Sims - Portage MI, US
Phil Bowman - Kalamazoo MI, US
Daniel Wade - Portage MI, US
Shri Valvani - Kalamazoo MI, US

International Classification:

A61B019/00

US Classification:

604403000

Abstract:

The present invention is a container for an IV aqueous solution of a Gram-positive oxazolidinone agent, such as linezolid a the compound of formula: which comprises having the container-solution contact surface material be a polyolefin.