Scott A Small

US Patent:

20050176668, Aug 11, 2005

Filed:

Nov 3, 2004

Appl. No.:

10/980921

Inventors:

Scott Small - New York NY, US
Tae-Wan Kim - Old Tappan NJ, US

International Classification:

A61K048/00
C12Q001/68

US Classification:

514044000, 435006000

Abstract:

This invention provides a method for determining whether an agent causes a reduction in the expression of a retromer complex protein. This invention further provides a method for determining whether an agent causes a reduction in the activity of a retromer complex. This invention also provides a method for reducing the expression of a retromer complex protein in a cell. This invention provides a method for treating a subject afflicted with Alzheimer's disease. This invention further provides a pharmaceutical composition as well as an article of manufacture. Finally, this invention provides a method for identifying a potential pathogenic nucleic acid transcript with respect to a brain disorder.

US Patent:

20060008416, Jan 12, 2006

Filed:

Nov 3, 2004

Appl. No.:

10/981108

Inventors:

Scott Small - New York NY, US

International Classification:

A61K 49/08

US Classification:

424009360

Abstract:

This invention provides a method for determining whether a subject is afflicted with Alzheimer's disease by comparing the metabolic activity of the subject's hippocampal entorhinal cortex with that of a second region of the subject's brain. This invention further provides a method for determining whether a subject is afflicted with Alzheimer's disease by comparing the metabolic activity of the subject's hippocampal entorhinal cortex determined at a first and second time point. Finally, this invention provides a method for determining the amount of blood in a volume of cerebral tissue in vivo, wherein the volume of tissue is 1 mmor less.

US Patent:

20090005711, Jan 1, 2009

Filed:

Mar 19, 2008

Appl. No.:

12/077612

Inventors:

Elisa E. Konofagou - New York NY, US
James J. Choi - Englewood NJ, US
Mathieu Pernot - Paris, FR
Scott A. Small - Millerton NY, US

International Classification:

A61N 7/00

US Classification:

601 2

Abstract:

A system and method for opening the blood-brain barrier in the brain of a subject is disclosed. In some embodiments, a region of the brain of a subject is targeted for opening; and a focused ultrasound beam is applied through the skull of the subject to the targeted region to open the blood-brain barrier in the brain of the subject.

US Patent:

20090246145, Oct 1, 2009

Filed:

Nov 14, 2006

Appl. No.:

12/085156

Inventors:

Scott A. Small - New York NY, US

International Classification:

A61K 49/00
A61K 31/551
A61K 31/519
A61K 31/445
A61K 31/137

US Classification:

424 9361, 514220, 514317, 514649, 51425941

Abstract:

This invention provides a method for treating a mammalian subject afflicted with a disorder associated with reduced neurogenesis in the subject's hippocampal dentate gyrus which comprises administering to the subject a therapeutically effective amount of a compound which increases cerebral blood volume in the subject's hippocampal dentate gyrus by a percentage greater than that by which it increases the cerebral blood volume in the subject's hippocampal CA1 region, thereby treating the subject.

US Patent:

20090253779, Oct 8, 2009

Filed:

Oct 19, 2006

Appl. No.:

12/083394

Inventors:

Scott A. Small - New York NY, US

International Classification:

A61K 31/7088
C12P 21/04
C12Q 1/00

US Classification:

514 44 R, 435 711, 435 4

Abstract:

This invention provides a method for increasing the expression of RbAp48 protein in a eukaryotic cell comprising introducing into the cell an agent which specifically increases the expression of RbAp48 protein in the cell. This invention also provides a method for treating a subject afflicted with age-related memory decline comprising administering to the subject a therapeutically effective amount of an agent which specifically increases the expression of RbAp48 protein in the cells of the subject's brain. This invention further provides a method for determining whether an agent causes an increase in the expression of RbAp48 protein. Finally, this invention provides a method for determining whether an agent causes an increase in the activity of RbAp48 protein.

US Patent:

20140288145, Sep 25, 2014

Filed:

Dec 4, 2012

Appl. No.:

14/362095

Inventors:

- Waltham MA, US
Gregory A. Petsko - New York NY, US
Scott A. Small - Millerton NY, US
Vincent Mecozzi - Boston MA, US

Assignee:

Brandeis University - Waltham MA

International Classification:

C07D 333/24
C07K 14/47

US Classification:

514438, 530402, 435375

Abstract:

The present invention provides pharmaceutical compositions and related methods for stabilizing retromer in cells.