Seung Mi Choi

US Patent:

20170157212, Jun 8, 2017

Filed:

Dec 2, 2016

Appl. No.:

15/368341

Inventors:

- La Jolla CA, US
Seung Hyuk Choi - La Jolla CA, US

Assignee:

Salk Institute for Biological Studies - La Jolla CA

International Classification:

A61K 38/17
A61K 45/06
C07K 14/47

Abstract:

Disclosed is a polypeptide that includes amino acids 183-222 of CRIF, wherein the polypeptide does not include the full length CRIF1 amino acid sequence. Also disclosed is a nucleic acid molecule encoding this polypeptide, vectors including this nucleic acid molecule, and host cells transformed with these vectors. In some embodiments, methods are disclosed for treating a subject with cancer, comprising administering to the subject a therapeutically effective amount of an inhibitor of CDK12/CRIF1 interaction, thereby treating the cancer in the subject. In specific non-limiting examples, these methods can utilize CRIF1 polypeptides, nucleic acids encoding these polypeptides, and vectors including these nucleic acids.