Shahid R Siddiqui

US Patent:

7662924, Feb 16, 2010

Filed:

Nov 7, 2005

Appl. No.:

11/267986

Inventors:

Oscar Colamonici - Chicago IL, US
Shahid Siddiqui - Wilmette IL, US

Assignee:

The Board of Trustees of the University of Illinois - Urbana IL

International Classification:

C07K 17/00
G01N 33/53

US Classification:

5303871, 435 71

Abstract:

The present invention provides β-subunit-Associated Regulator of Apoptosis, or BARA, polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, non-human transgenic animals, devices and methods for producing BARA polypeptides. The invention further provides compositions comprising BARA nucleic acids, polypeptides, and fusions or derivatives thereof. The invention further provides methods for treating, preventing, or ameliorating a medical disease, condition, or disorder comprising administering BARA or BARA compositions, as well as methods of diagnosing a pathological condition related to BARA. Still further, the invention provides methods of modulating levels of BARA expression and methods of determining whether a compound stimulates or inhibits BARA polypeptide activity or BARA polypeptide production.

US Patent:

7825101, Nov 2, 2010

Filed:

Aug 30, 2007

Appl. No.:

12/439370

Inventors:

Dolly Mehta - Elmhurst IL, US
Shahid S. Siddiqui - Wilmette IL, US
Asrar Malik - Hinsdale IL, US

Assignee:

The Board of Trustees of the University of Illinois - Urbana IL

International Classification:

A61K 31/70
C07H 21/04

US Classification:

514 44, 536 245

Abstract:

In various aspects and embodiments the invention provides methods and reagents for controlling gene expression, and for treating disorders and diseases. Embodiments provide methods and reagents specifically for the regulation of MLCK expression and for the use thereof in treating disorders and diseases. Various embodiments provide methods and reagents for specifically down regulating the expression of MLCK-L more efficiently than that of MLCK-S, and for the use thereof in treating disorders and diseases. Embodiments provide siNA for the same, particularly siRNAs. Various of the embodiments are useful for the treatment of inflammatory disorders and diseases, including, for one example in this regard, Asthma.

US Patent:

8067389, Nov 29, 2011

Filed:

Jul 20, 2009

Appl. No.:

12/505911

Inventors:

Nalin M. Kumar - Wilmette IL, US
Beatrice Yue - Deerfield IL, US
Shahid Siddiqui - Wilmette IL, US
Asrar B. Malik - Hinsdale IL, US
Jose S. Pulido - Rochester MN, US

Assignee:

The Broad of Trustees of the University of Illinois - Chicago IL

International Classification:

A61K 31/70
C07H 21/02
C07H 21/04
C12Q 1/68
C12N 5/00

US Classification:

514 44A, 536 231, 536 241, 536 245, 435375

Abstract:

The present application is directed to siRNA-based silencing of the type II receptor of TGFβ. siRNAs that target this receptor abrogate the receptor protein and transcript, TGFβ-mediated processes such as fibronectin assembly and cell migration also are inhibited and the molecules of the invention are efficacious in reducing the inflammatory response and matrix deposition. These findings show that siRNAs can be successfully delivered both in vitro and in vivo to regulate the TGFβ type II receptor level and modulate wound response. Methods and compositions exploiting the findings of the present invention have a wide-ranging application, extending from treatment of disorders of the eye to other organs and tissues throughout the body.

US Patent:

20040025194, Feb 5, 2004

Filed:

Feb 24, 2003

Appl. No.:

10/373228

Inventors:

Oscar Colamonici - Chicago IL, US
Shahid Siddiqui - Wilmette IL, US

Assignee:

Board of Trustees of the University of Illinois - Urbana IL

International Classification:

A01K067/00
C07H021/04
C12N009/99
C12P021/02
C12N005/06

US Classification:

800/008000, 435/069200, 435/184000, 435/320100, 435/325000, 536/023200

Abstract:

The present invention provides -subunit-Associated Regulator of Apoptosis, or BARA, polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, non-human transgenic animals, devices and methods for producing BARA polypeptides. The invention further provides compositions comprising BARA nucleic acids, polypeptides, and fusions or derivatives thereof. The invention further provides methods for treating, preventing, or ameliorating a medical disease, condition, or disorder comprising administering BARA or BARA compositions, as well as methods of diagnosing a pathological condition related to BARA. Still further, the invention provides methods of modulating levels of BARA expression and methods of determining whether a compound stimulates or inhibits BARA polypeptide activity or BARA polypeptide production.

US Patent:

20060229266, Oct 12, 2006

Filed:

Aug 10, 2004

Appl. No.:

10/567958

Inventors:

Nalin Kumar - Wilmette IL, US
Beatrice Yue - Deerfield IL, US
Shahid Siddiqui - Wilmette IL, US
Asrar Malik - Hinsdale IL, US
Jose Pulido - Brookfield WI, US

International Classification:

A61K 48/00
C07H 21/02

US Classification:

514044000, 536023100

Abstract:

The present application is directed to siRNA-based silencing of the type II receptor of TGFβ. siRNAs that target this receptor abrogate the receptor protein and transcript, TGFβ-mediated processes such as fibronectin assembly and cell migration also are inhibited and the molecules of the invention are efficacious in reducing the inflammatory response and matrix deposition. These findings show that siRNAs can be successfully delivered both in vitro and in vivo to regulate the TGFβ type II receptor level and modulate wound response. Methods and compositions exploiting the findings of the present invention have a wide-ranging application, extending from treatment of disorders of the eye to other organs and tissues throughout the body.

US Patent:

20110092568, Apr 21, 2011

Filed:

Sep 23, 2010

Appl. No.:

12/888947

Inventors:

DOLLY MEHTA - ELMHURST IL, US
SHAHID S. SIDDIQUI - WILMETTE IL, US
ASRAR MALIK - HINSDALE IL, US

Assignee:

THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS - URBANA IL

International Classification:

A61K 31/713
C07H 21/02
A61P 29/00
A61P 11/06

US Classification:

514 44 A, 536 245

Abstract:

In various aspects and embodiments the invention provides methods and reagents for controlling gene expression, and for treating disorders and diseases. Embodiments provide methods and reagents specifically for the regulation of MLCK expression and for the use thereof in treating disorders and diseases. Various embodiments provide methods and reagents for specifically down regulating the expression of MLCK-L more efficiently than that of MLCK-S, and for the use thereof in treating disorders and diseases. Embodiments provide siNA for the same, particularly siRNAs. Various of the embodiments are useful for the treatment of inflammatory disorders and diseases, including, for one example in the regard, Asthma.