Shawn Adam Levy

US Patent:

20050091704, Apr 28, 2005

Filed:

Sep 2, 2003

Appl. No.:

10/654628

Inventors:

Douglas Wallace - Irvine CA, US
Grant MacGregor - Irvine CA, US
Katrina Waymire - Irvine CA, US
Shawn Levy - Brentwood TN, US
James Sligh - Brentwood TN, US
Jason Kokoszka - Frederick MD, US

Assignee:

Emory University - Atlanta GA

International Classification:

A01K067/027
C12N005/06

US Classification:

800018000, 435354000

Abstract:

Described are methods for inactivating adenine nucleotide transporter proteins in specific tissues of a transgenic nonhuman animal using a conditional knockin/knockout technology such as the Cre-LoxP, Flip-FLP recombinase, or Tet-on/off technologies. Specifically, the Ant2 gene is functionally inactivated in a mouse in liver, with or without the concurrent inactivation of the Ant1 gene. The result is an animal in which the Ant2 gene and accompanying ANT2 protein is absent in one or more tissues, either in the presence or absence of the Ant1 gene and accompanying ANT1 protein. The resulting animals, cells, mitochondria, and subcelluar fractions such as the mitochondrial permeability transition pore can then be used to identify agents that affect animal and/or subcellular function via a direct or indirect interaction with the ANT2 protein and/or its Ant2 gene.

US Patent:

20060099578, May 11, 2006

Filed:

Aug 30, 2002

Appl. No.:

10/488619

Inventors:

Douglas Wallace - Irvine CA, US
Shawn Levy - Brentwood TN, US
Keith Kerstann - Atlanta GA, US
Vincent Procaccio - Irvine CA, US

International Classification:

C12Q 1/68
C12M 1/34

US Classification:

435006000, 435287200

Abstract:

This invention provides a library of genes involved in mitochondrial biology, arrays containing probes for genes involved in mitochondrial biology, methods for making such arrays, and methods of using such arrays. Genes and probe sequences involved in mitochondrial biology in humans and mice are provided. The arrays of this invention are useful for determining mitochondrial biology gene expression profiles. Mitochondrial biology gene expression profiles are useful for determining expression profiles diagnostic of physiological conditions; diagnosing physiological conditions; identifying biochemical pathways, genes, and mutations involved in physiological conditions; identify therapeutic agents useful for preventing and/or treating such physiological conditions; evaluating and/or monitoring the efficacy of such therapies, and creating and identifying animal models of human physiologic conditions. Arrays containing probes for all genes known to be involved in mitochondrial biology are provided, as well as arrays containing subsets of such probes.

US Patent:

20080268445, Oct 30, 2008

Filed:

Oct 12, 2007

Appl. No.:

11/871956

Inventors:

Douglas C. Wallace - Irvine CA, US
Grant MacGregor - Irvine CA, US
Katrina Waymire - Irvine CA, US
Shawn E. Levy - Hendersonville TN, US
James E. Sligh - Tucson AZ, US
Jason E. Kokoszka - Fairhope AL, US

Assignee:

Emory University - Atlanta GA

International Classification:

C12Q 1/68
A01K 67/027
C12N 5/18
C12Q 1/02
G01N 33/68

US Classification:

435 6, 800 18, 435354, 4353171, 435 29, 436 86

Abstract:

Described are methods for inactivating adenine nucleotide transporter proteins in specific tissues of a transgenic nonhuman animal using a conditional knockin/knockout technology such as the Cre-LoxP, Flip-FLP recombinase, or Tet-on/off technologies. Specifically, the Ant2 gene is functionally inactivated in a mouse in liver, with or without the concurrent inactivation of the Ant1 gene. The result is an animal in which the Ant2 gene and accompanying ANT 2 protein is absent in one or more tissues, either in the presence or absence of the Ant1 gene and accompanying protein. The resulting animals, cells, mitochondria, and subcelluar fractions such as the mitochondrial permeability transition pore can then be used to identify agents that affect animal and/or subcellular function via a direct or indirect interaction with the ANT2 protein and/or its Ant2 gene.

Address:

16255 Ventura Blvd, Encino, CA 91436

Phone:

(818)7895090

VIN:

5FNRL3H95AB107499

Make:

HONDA

Model:

ODYSSEY

Year:

2010