Abstract:
A compound of formula Ia or formula Ib, or a pharmaceutically acceptable salt or ester thereof, wherein Ris selected from: aryl; heteroaryl; —NHR; fused aryl-C-heterocycloalkyl; —CONRR; —NHCOR; —C-cycloalkyl; -0-C-cycloalkyl; —NRR; and optionally substituted —Calkyl; wherein said aryl, heteroaryl, fused aryl-C-heterocycloalkyl and C-heterocycloalkyl are each optionally substituted; Q is CN, halogen, or is selected from C-alkyl, C-cycloalkyl, heterocycloalkyl, aryl and heteroaryl, each of which is optionally substituted with one or more substituents A; Ris selected from hydrogen, aryl, C-alkyl, C-alkenyl, C-cycloalkyl, heteroaryl, C-heterocycloalkyl and halogen, wherein said C-alkyl, Cz-B-alkenyl, aryl, heteroaryl and C-heterocycloalkyl are each optionally substituted; Ris selected from aryl, heteroaryl, C-heterocycloalkyl, C-cycloalkyl, fused aryl-C-heterocycloalkyl and C-alkyl, each of which is optionally substituted; Rand Rare each independently hydrogen, or optionally substituted C-cycloalkyl, aryl, heteroaryl, C-alkyl or C-heterocycloalkyl; or Rand Rtogether with the N to which they are attached form a C-heterocycloalkyl ring; each Ris independently selected from C-alkyl, C-cycloalkyl, C-heterocycloalkyl, aryl and heteroaryl, each of which is optionally substituted; each Ris selected from hydrogen, optionally substituted C-alkyl and C-cycloalkyl; each of Rand Ris independently hydrogen or optionally substituted C-alkyl; or Rand Rtogether with the N to which they are attached form a C-heterocycloalkyl; each Ris selected from C-cycloalkyl and optionally substituted C-alkyl; each Ris independently selected from C-alkyl, C-cycloalkyl, C-alkyl-C-cycloalkyl, C-heterocycloalkyl, aryl and heteroaryl, each of which is optionally substituted; A is selected from halogen, —NRS0R, —CN, —OR, —NRR, —NRR, hydroxyl, —CF, —CONRR, —NRCOR, —NR(CO)NRR, —N0, —C0H, —C0R, —S0R, —S0NRR, —NRCOR, —NRCOOR, -alkyl and —COR. Further aspects relate to pharmaceutical compositions, therapeutic uses and process for preparing compounds of formulae Ia and Ib.