Steven W Pedersen

US Patent:

7256217, Aug 14, 2007

Filed:

Dec 14, 2001

Appl. No.:

10/250448

Inventors:

David Scott Coffey - Indianapolis IN, US
James Allen Monn - Indianapolis IN, US
Concepcion Pedregal-Tercero - Madrid, ES
Steven Wayne Pedersen - Indianapolis IN, US

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K 31/16
C07C 233/23

US Classification:

514619, 564193

Abstract:

This invention relates to synthetic excitatory amino acid prodrugs according to formula (I) and processes for their preparation. The invention further relates to methods of using, and pharmaceutical compositions comprising, the compounds for the treatment of neurological disorders and psychiatric disorders.

US Patent:

7381826, Jun 3, 2008

Filed:

Oct 12, 2004

Appl. No.:

10/574712

Inventors:

Alfio Borghese - Rue Granbonpre', BE
David Scott Coffey - Indianapolis IN, US
Pamela Kaye Footman - Indianapolis IN, US
Steven Wayne Pedersen - Indianapolis IN, US
Susan Marie Reutzel-Edens - Zionsville IN, US
Shella Lenyonga Tameze - Indianapolis IN, US
Carsten Timpe - Hamburg, DE
Carsten Weber - Hamburg, DE

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

C07D 401/14
A61K 31/535

US Classification:

546256, 514333

Abstract:

The present invention provides novel crystalline forms of {2-[1-(3,5-bistrifluoromethylbenzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone, compositions thereof, intermediates thereof, methods of using the same, processes for making the same, and processes for making intermediates thereof.

US Patent:

7456221, Nov 25, 2008

Filed:

Jul 5, 2007

Appl. No.:

11/773647

Inventors:

David Scott Coffey - Indianapolis IN, US
James Allen Monn - Indianapolis IN, US
Concepcion Pedregal-Tercero - Madrid, ES
Steven Wayne Pedersen - Indianapolis IN, US

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K 31/16
C07C 233/23

US Classification:

514619, 564193

Abstract:

This invention relates to synthetic excitatory amino acid prodrugs and processes for their preparation. The invention further relates to methods of using, and pharmaceutical compositions comprising, the compounds for the treatment of neurological disorders and psychiatric disorders.

US Patent:

20030153764, Aug 14, 2003

Filed:

May 28, 2002

Appl. No.:

10/148714

Inventors:

Alexander Godfrey - Greenwood IN, US
Steven Pedersen - Indianapolis IN, US

International Classification:

C07D211/44

US Classification:

546/217000

Abstract:

The present invention provides a process for preparing N-protected-4-substituted piperidines of formula (I) wherein Pg represents a suitable nitrogen protecting group; X represents a heterocycle, substituted heterocycle, substituted alkenyl or substituted aryl wherein the substituted heterocycle, substituted alkenyl or substituted aryl are substituted with from 1 to 3 suitable activating groups; and R, R, R, R, R, R, R, and Reach independently represent an alkyl, alkenyl, cycloalkyl, aryl, substituted aryl, heterocycle, or substituted heterocycle, comprising treating a compound of formula (II) wherein the substituents are defined as above, with triethylsilane and trifluoroacetic acid.

US Patent:

20100331309, Dec 30, 2010

Filed:

Jun 28, 2010

Appl. No.:

12/824355

Inventors:

Xinchao Chen - Schenectady NY, US
Scott Alan Frank - Indianapolis IN, US
David Michael Remick - Fishers IN, US
Steven Wayne Pedersen - Indianapolis IN, US

Assignee:

ELI LILLY AND COMPANY - Indianapolis IN

International Classification:

A61K 31/55
C07D 403/12
A61P 9/10

US Classification:

51421301, 540593

Abstract:

Compounds of a formulaentitled, trans-4-[[(5S)-5-[[[3,5-bis(trifluoromethyl)phenyl]methyl](2-methyl-2H-tetrazol-5-yl)amino]-2,3,4,5-tetrahydro-7,9-dimethyl-1H-1-benzazepin--yl]methyl]-cyclohexanecarboxylic acid, as a free acid or a pharmaceutically acceptable salt thereof; and hydrates and other solvates in crystalline form; pharmaceutical formulations; and methods of use are disclosed.

US Patent:

20120058990, Mar 8, 2012

Filed:

Jun 28, 2010

Appl. No.:

13/318874

Inventors:

Xinchao Chen - Schenectady NY, US
Scott Alan Frank - Indianapolis IN, US
Steven Wayne Pedersen - Indianapolis IN, US
David Michael Remick - Fishers IN, US

Assignee:

ELI LILLY AND COMPANY - Indianapolis IN

International Classification:

A61K 31/55
A61P 9/10
C07D 403/12

US Classification:

51421301, 540593

Abstract:

Abstract Compounds of a formula entitled, trans-4-[[(5S)-5-[[[3,5-bis(trifluoromethyl)phenyl]methyl](2-methyl-2H-tetrazol-5-yl)amino]-2,3,4,5-tetrahydro-7,9-dimethyl-1H-1-benzazepin-1-yl]methyl]-cyclohexanecarboxylic acid, as a free acid or a pharmaceutically acceptable salt thereof, hydrate, and hydrate in crystalline form; pharmaceutical formulations; and methods of use are disclosed.