Thomas P Demuth

US Patent:

20030236296, Dec 25, 2003

Filed:

Jun 9, 2003

Appl. No.:

10/457181

Inventors:

John Wos - Maineville OH, US
David Soper - Mason OH, US
Steven O'Neil - Morrow OH, US
Yili Wang - Mason OH, US
Kofi Oppong - Fairfield OH, US
Michael Laufersweiler - Maineville OH, US
Jian Chen - Mason OH, US
Biswanath De - Cincinnati OH, US
Thomas Demuth - Cincinnati OH, US

Assignee:

The Procter & Gamble Company

International Classification:

C07D471/02
A61K031/403

US Classification:

514/412000, 540/461000

Abstract:

The present invention relates to interleukin-1 converting enzyme inhibitors having the formula: R is a carbocyclic or heterocyclic ring; Ris a cysteine trap; R, R, R, and Rare each independently hydrogen, C-Calkyl, C-Calkoxy, and mixtures thereof; or R and R can taken together to form a double bond; L and Lare linking groups having the formula: T is selected from the group consisting of: i) —NR—; ii) —O—; iii) —NRS(O)—; iv) —S(O)NR—; and v) mixtures thereof; Ris hydrogen, substituted or unsubstituted C-Clinear, branched, or cyclic alkyl, C-Caryl, C-Calkylenearyl, and mixtures thereof; the indices w, w, and ware each independently 0 or 1; i) hydrogen; ii) C-Clinear, branched, and cyclic alkyl; iii) Rand Ror R, and Rcan be taken together to form a carbonyl unit; iv) two Ror two Runits from adjacent carbon atoms or two Ror two Runits from adjacent carbon atoms can be taken together to form a double bond; and v) mixtures thereof; the index m is from 0 to 5; the index n is from 0 to 5.

US Patent:

20040009966, Jan 15, 2004

Filed:

Jun 9, 2003

Appl. No.:

10/457720

Inventors:

John Wos - Maineville OH, US
Yili Wang - Mason OH, US
Kofi Oppong - Fairfield OH, US
Steven O'Neil - Morrow OH, US
Michael Laufersweiler - Maineville OH, US
David Soper - Mason OH, US
Biswanath De - Cincinnati OH, US
Thomas Demuth - Cincinnati OH, US

Assignee:

The Procter & Gamble Company

International Classification:

A61K031/554
A61K031/553
A61K031/55
C07D281/02
C07D291/08

US Classification:

514/211030, 514/212030, 514/218000, 540/488000, 540/492000, 540/527000, 540/531000

Abstract:

The present invention relates to novel compounds, compositions comprising said compounds, and uses thereof, said compounds having the formula: wherein each X is independently selected from: i) —C(W)—; ii) —C(O)—; iii) —NR—; iv) —S—; v) —S(O)—; vi) —S(O)—; vii) two units, one from each adjacent X unit, can be taken together to form a substituted or unsubstituted double bond having the formula —CW CW—; wherein each W is hydrogen of a unit having the formula —(L)—R, the index j is 0 or 1; R is a carbocyclic or heterocyclic aryl ring; Ris a cysteine trap; each Ris independently a suitable substituent; and L, L, and Lare linking units.

US Patent:

20040014753, Jan 22, 2004

Filed:

Jun 9, 2003

Appl. No.:

10/457188

Inventors:

Steven O'Neil - Morrow OH, US
Michael Laufersweiler - Maineville OH, US
Yili Wang - Mason OH, US
Kofi Oppong - Fairfield OH, US
David Soper - Mason OH, US
John Wos - Maineville OH, US
Biswanath De - Cincinnati OH, US
Thomas Demuth - Cincinnati OH, US

Assignee:

The Procter & Gamble Company

International Classification:

A61K031/538
A61K031/498
A61K031/4745
C07D491/02
C07D487/02

US Classification:

514/230500, 514/249000, 514/300000, 540/476000

Abstract:

The present invention relates to novel compounds, compositions comprising said compounds, and uses thereof, said compounds having the formula: X is —CH—, —O— or —NR—; R is a carbocyclic or heterocyclic ring; Ris a cysteine trap; R, R, R, and R are each independently hydrogen, C-Calkyl, C-Calkoxy, and mixtures thereof; or R and R can taken together to form a double bond; Ris hydrogen or a unit having the formula —L—R; L is the same as defined herein above; Ris hydrogen; substituted or unsubstituted C-Clinear; branched, or cyclic hydrocarbyl; substituted or unsubstituted aryl; substituted or unsubstituted C-Cheterocyclic; and substituted or unsubstituted heteroaryl.

US Patent:

53877489, Feb 7, 1995

Filed:

May 2, 1991

Appl. No.:

7/696985

Inventors:

Thomas P. Demuth - Norwich NY
Ronald E. White - South Plymouth NY

Assignee:

Procter & Gamble Pharmaceuticals, Inc. - Norwich NY

International Classification:

C07D50120
A61K 31495

US Classification:

514254

Abstract:

Antimicrobial dithiocarbamoyl quinolone compounds of the general formula: ##STR1## wherein (1) A. sup. 1, A. sup. 2, A. sup. 3, R. sup. 1, R. sup. 3, R. sup. 4, and R. sup. 6 form any of a variety of quinolone and related heterocyclic structures similar to those known in the art to have antimicrobial activity; and (2) (1) R. sup. 1 is X, R. sup. 3 is X, or both R. sup. 1 and R. sup. 3 are X; and (2) X is --R. sup. 15 --N(R. sup. 16)(R. sup. 17) or --R. sup. 15 --R. sup. 18 --N(R. sup. 19)(R. sup. 17), where (a) (1) R. sup. 15 is nil, alkyl, a carbocyclic ring, or a heterocyclic ring; and (2) R. sup. 16 is hydrogen; alkyl; alkenyl; a carbocyclic ring; a heterocyclic ring; or (3) when X is R. sup. 15 --N(R. sup. 16)(R. sup. 17), R. sup. 16 and R. sup. 15 may together comprise a heterocyclic ring including the nitrogen atom to which R. sup. 15 and R. sup. 16 are bonded; (b) R. sup. 17 is C(. dbd.

US Patent:

56726007, Sep 30, 1997

Filed:

Oct 21, 1994

Appl. No.:

8/327063

Inventors:

Thomas Prosser Demuth - Norwich NY
Ronald Eugene White - South Plymouth NY

Assignee:

The Procter & Gamble Company - Cincinnati OH

International Classification:

A61K 3147
A61K 31495
C07D40100
C07D40300

US Classification:

5142245

Abstract:

Antimicrobial dithiocarbamoyl quinolone compounds of the general formula: ##STR1## wherein (1) A. sup. 1, A. sup. 2, A. sup. 3, R. sup. 1, R. sup. 3, R. sup. 4, and R. sup. 6 form any of a variety of quinolone and related heterocyclic structures similar to those known in the art to have antimicrobial activity; and (2) (1) R. sup. 1 is X, R. sup. 3 is X, or both R. sup. 1 and R. sup. 3 are X; and X is the dithiocarbamate containing moiety; and pharmaceutically-acceptable salts and biohydrolyzable esters thereof, and hydrates thereof.

US Patent:

55301169, Jun 25, 1996

Filed:

Dec 22, 1994

Appl. No.:

8/361919

Inventors:

Thomas P. Demuth - Norwich NY
Ronald E. White - South Plymouth NY

Assignee:

The Procter & Gamble Company - Cincinnati OH

International Classification:

C07D50157

US Classification:

540221

Abstract:

Antimicrobial quinolonyl lactam compounds comprising a lactam-containing moiety linked to a quinolone moiety, of the formula: ##STR1## wherein (1) A. sup. 1, A. sup. 2, A. sup. 3, R. sup. 1, and R. sup. 4 generally form any of a variety of quinolone, naphthyridine or related cyclic moieties known in the art to have antimicrobial activity; and (2) R. sup. 6 is part of a linking moiety, linking the quinolone moiety to a lactam-containing moiety having the formula: ##STR2## wherein (3) R. sup. 10, R. sup. 11, R. sup. 12, R. sup. 13, and R. sup. 14, together with bonds "a" and "b", form any of a variety of lactam-containing moieties known in the art to have antimicrobial activity; and (4) the linking moiety includes (for example) carbamate, dithiocarbamate, urea, thiourea, isouronium, isothiouronium, guanidine, carbonate, trithiocarbonate, reversed carbamate, xanthate, reversed isouronium, reversed dithiocarbamate, reversed isothiouronium, amine, imine, ammonium, heteroarylium, ether, thioether, ester, thioester, amide, and hydrazide groups.

US Patent:

53289080, Jul 12, 1994

Filed:

Apr 20, 1990

Appl. No.:

7/513368

Inventors:

Thomas P. Demuth - Norwich NY
Ronald E. White - South Plymouth NY

Assignee:

Procter & Gamble Pharmaceuticals, Inc. - Norwich NY

International Classification:

C07D50120
C07D50130
A61K 31495

US Classification:

514254

Abstract:

Antimicrobial quinolone thiourea compounds of the general formula: ##STR1## wherein (1) A. sup. 1, A. sup. 2, A. sup. 3, R. sup. 1, R. sup. 3, R. sup. 4, and R. sup. 6 form any of a variety of quinolone and related heterocyclic structures similar to those known in the art to have antimicrobial activity; and (2) (1) R. sup. 1 is X, R. sup. 3 is X, or both R. sup. 1 and R. sup. 3 are X; and (2) X is --R. sup. 15 --N(R. sup. 16)(R. sup. 17) or --R. sup. 15 --R. sup. 18 --N(R. sup. 19)(R. sup. 17), where (a) (1) R. sup. 15 is nil, alkyl, a carbocyclic ring, or a heterocyclic ring; and (2) R. sup. 16 is hydrogen; alkyl; alkenyl; a carbocyclic ring; a heterocyclic ring; or (3) when X is R. sup. 15 --N(R. sup. 16)(R. sup. 17), R. sup. 16 and R. sup. 15 may together comprise a heterocyclic ring including the nitrogen atom to which R. sup. 15 and R. sup. 16 are bonded; (b) R. sup. 17 is C(. dbd. S)--NR. sup. 20 R. sup.

US Patent:

56483465, Jul 15, 1997

Filed:

Jun 7, 1995

Appl. No.:

8/477724

Inventors:

Ronald Eugene White - South Plymouth NY
Thomas Prosser Demuth - Norwich NY

Assignee:

The Procter & Gamble Company - Cincinnati OH

International Classification:

C07D47706
C07D46300
A61K 31435
A61K 3140

US Classification:

514210

Abstract:

A substantially flat collapsed plastic bag with an evacuation form unit insert positioned therein as manufactured to serve as a form about which the filled bag will collapse as it is emptied. The form unit comprises a ring for mounting the unit on the spout of the bag and a multi-channel form extending radially from the ring and hingedly connected thereto. A simple method is provided for manufacturing the bag with the form unit insert.