Timothy Alan Robbins

US Patent:

7354937, Apr 8, 2008

Filed:

Jul 7, 2005

Appl. No.:

11/176087

Inventors:

Michael J. Buckley - Ingleside IL, US
Jianguo Ji - Libertyville IL, US
Geoff G. Z. Zhang - Libertyville IL, US
Rodger F. Henry - Wildwood IL, US
Weili W. Wang - Buffalo Grove IL, US
Gregory S. Wayne - Vernon Hills IL, US
Wenke Li - Gurnee IL, US
Timothy B. Towne - Lindenhurst IL, US
Steven J. Wittenberger - Mundelein IL, US
Steven M. Hannick - Highland Park IL, US
Brian J. Kotecki - Oak Creek WI, US
Bryan S. Macri - Gurnee IL, US
Timothy A. Robbins - Grayslake IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 31/4745
C07D 487/04

US Classification:

514339, 5462767

Abstract:

The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3. 2. 0]heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.

US Patent:

7538226, May 26, 2009

Filed:

Aug 14, 2007

Appl. No.:

11/838745

Inventors:

Michael J. Buckley - McHenry IL, US
Jianguo Ji - Libertyville IL, US
Geoff G. Z. Zhang - Libertyville IL, US
Rodger F. Henry - Wildwood IL, US
Weili W. Wang - Buffalo Grove IL, US
Gregory S. Wayne - Vernon Hills IL, US
Wenke Li - Gurnee IL, US
Timothy B. Towne - Lindenhurst IL, US
Steven J. Wittenberger - Mundelein IL, US
Steven M. Hannick - Highland Park IL, US
Brian J. Kotecki - Oak Creek WI, US
Bryan S. Macri - Gurnee IL, US
Timothy A. Robbins - Grayslake IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07D 487/04

US Classification:

5462767

Abstract:

The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3. 2. 0]heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.

US Patent:

7541475, Jun 2, 2009

Filed:

Jul 30, 2004

Appl. No.:

10/903553

Inventors:

Timothy A. Robbins - Gurnee IL, US
Helen Zhu - South Bend IN, US
Jun Shao - Mason OH, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07D 277/04

US Classification:

548201, 564 74

Abstract:

This invention is directed to processes for making substituted thiazoles. The substituted thiazole, ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate, also known as TEI-6720, is useful for treatment of gout and hyperuricemia. This compound belongs to a class of substituted thiazoles that inhibit xanthine oxidase and thus block uric acid production.

US Patent:

20050027128, Feb 3, 2005

Filed:

Jul 30, 2003

Appl. No.:

10/630043

Inventors:

Timothy Robbins - Gurnee IL, US
Helen Zhu - South Bend IN, US
Jun Shao - Mason OH, US

International Classification:

C12Q001/68
C 07D 2 7/333
C07C327/48

US Classification:

548530000, 564074000

Abstract:

This invention is directed to processes for making substituted thiazoles. The substituted thiazole, ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate, also known as TEI-6720, is useful for treatment of gout and hyperuricemia. This compound belongs to a class of substituted thiazoles that inhibit xanthine oxidase and thus block uric acid production.

US Patent:

20090203664, Aug 13, 2009

Filed:

Apr 20, 2009

Appl. No.:

12/426511

Inventors:

Michael J. Buckley - McHenry IL, US
Jianguo Ji - Libertyville IL, US
Geoff G.Z. Zhang - Libertyville IL, US
Rodger F. Henry - Wildwood IL, US
Weili W. Wang - Buffalo Grove IL, US
Gregory S. Wayne - Vernon Hills IL, US
Wenke Li - Gurnee IL, US
Timothy B. Towne - Lindenhurst IL, US
Steven J. Wittenberger - Mundelein IL, US
Steven M. Hannick - Highland Park IL, US
Brian J. Kotecki - Oak Creek WI, US
Bryan S. Macri - Gurnee IL, US
Timothy A. Robbins - Grayslake IL, US

Assignee:

ABBOTT LABORATORIES - Abbott Park IL

International Classification:

A61K 31/397
A61P 25/00
A61P 25/28
C07D 401/14

US Classification:

51421016, 5462767

Abstract:

The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.

US Patent:

55413285, Jul 30, 1996

Filed:

Apr 3, 1995

Appl. No.:

8/415385

Inventors:

Timothy L. Stuk - Lindenhurst IL
Michael S. Allen - Silver Lake WI
Anthony R. Haight - Mundelein IL
Francis A. Kerdesky - Grayslake IL
Denton C. Langridge - Wildwood IL
M. Robert Leanna - Grayslake IL
Linda M. Lijewski - Milwaukee WI
Laura Melcher - Deerfield IL
Howard E. Morton - Gurnee IL
Daniel W. Norbeck - Crystal Lake IL
Daniel S. Reno - Kenosha WI
Timothy A. Robbins - Gurnee IL
Hing L. Sham - Mundelein IL
Thomas J. Sowin - Grayslake IL
Chen Zhao - Gurnee IL
David Scarpetti - Baltimore MD

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07C25178
C07C22114
C07C20944

US Classification:

546 99

Abstract:

A substantially pure compound of formula: ##STR1## wherein R. sub. 6 and R. sub. 7 are independently selected from ##STR2## wherein R. sub. a and R. sub. b are independently selected from hydrogen, loweralkyl and phenyl and R. sub. c, R. sub. d and R. sub. e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR3## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or R. sub. 6 is as defined above and R. sub. 7 is R. sub. 7a OC(O)-- wherein R. sub. 7a is loweralkyl; or R. sub. 6 and R. sub. 7 taken together with the nitrogen atom to which they are bonded are ##STR4## wherein R. sub. f, R. sub. g, R. sub. h and R. sub. l are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl; and R. sub. g is hydrogen, loweralkyl or benzyl; or an acid addition salt thereof.

US Patent:

56250924, Apr 29, 1997

Filed:

Apr 10, 1995

Appl. No.:

8/419168

Inventors:

Timothy L. Stuk - Lindenhurst IL
Michael S. Allen - Silver Lake WI
Anthony R. Haight - Mundelein IL
Francis A. J. Kerdesky - Grayslake IL
Denton C. Langridge - Wildwood IL
M. Robert Leanna - Grayslake IL
Linda M. Lijewski - Milwaukee WI
Laura Melcher - Deerfield IL
Howard E. Morton - Gurnee IL
Daniel W. Norbeck - Crystal Lake IL
Daniel S. Reno - Kenosha WI
Timothy A. Robbins - Gurnee IL
David Scarpetti - Evanston IL
Hing L. Sham - Mundelein IL
Thomas J. Sowin - Grayslake IL
Chen Zhao - Gurnee IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07C26100
C07C23300
C07D20904

US Classification:

560 24

Abstract:

Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of the formula: ##STR1## wherein R. sub. 6 and R. sub. 7 are each hydrogen or R. sub. 6 and R. sub. 7 are independently selected from ##STR2## wherein R. sub. a and R. sub. b are independently selected from hydrogen, loweralkyl and phenyl and R. sub. c, R. sub. d and R. sub. e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR3## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or R. sub. 6 is as defined above and R. sub. 7 is R. sub. 7a OC(O)-- wherein R. sub. 7a is loweralkyl or benzyl; or R. sub. 6 and R. sub.

US Patent:

55697771, Oct 29, 1996

Filed:

Apr 7, 1995

Appl. No.:

8/418727

Inventors:

Timothy L. Stuk - Lindenhurst IL
Anthony R. Haight - Mundelein IL
Howard E. Morton - Gurnee IL
Timothy A. Robbins - Gurnee IL
David Scarpetti - Evanston IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07C26100
C07C23300
C07D20904

US Classification:

560 24

Abstract:

Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of the formula: ##STR1## wherein R. sub. 6 and R. sub. 7 are each hydrogen or R. sub. 6 and R. sub. 7 are independently selected from ##STR2## wherein R. sub. a and R. sub. b are independently selected from hydrogen, loweralkyl and phenyl and R. sub. c, R. sub. d and R. sub. e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR3## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or R. sub. 6 is as defined above and R. sub. 7 is R. sub. 7a OC(O)-- wherein R. sub. 7a is loweralkyl or benzyl; or R. sub. 6 and R. sub.