Todd A Gross

US Patent:

6424847, Jul 23, 2002

Filed:

Feb 23, 2000

Appl. No.:

09/511580

Inventors:

John J. Mastrototaro - Los Angeles CA
Todd M. Gross - Saugus CA
John J. Shin - Glendale CA

Assignee:

Medtronic Minimed, Inc. - Northridge CA

International Classification:

A61B 500

US Classification:

600316, 600365, 600322

Abstract:

A method of calibrating glucose monitor data includes collecting the glucose monitor data over a period of time at predetermined intervals. It also includes obtaining at least two reference glucose values from a reference source that temporally correspond with the glucose monitor data obtained at the predetermined intervals. Also included is calculating the calibration characteristics using the reference glucose values and the corresponding glucose monitor data to regress the obtained glucose monitor data. And calibrating the obtained glucose monitor data using the calibration characteristics is included. In preferred embodiments, the reference source is a blood glucose meter, and the at least two reference glucose values are obtained from blood tests. In additional embodiments, the calculation of the calibration characteristics is obtained using linear regression and in particular embodiments, least squares linear regression. Alternatively, the calculation of the calibration characteristics is obtained using non-linear regression.

US Patent:

6737401, May 18, 2004

Filed:

Oct 18, 2001

Appl. No.:

09/981968

Inventors:

Seonyoung Kim - Winnetka CA
William P. Van Antwerp - Valencia CA
Todd M. Gross - Saugus CA
Poonam S. Gulati - La Canada CA

Assignee:

Metronic MiniMed, Inc. - Northridge CA

International Classification:

A61K 3828

US Classification:

514 4, 514 2, 530300, 530303, 435 71, 435 4

Abstract:

Embodiments of the invention are directed to a method of estimating the physical stability of a protein formulation. A particular embodiment of the invention places the protein formulation under an agitational stress that causes the protein to aggregate at an accelerated rate. In one embodiment, the change in protein aggregation is monitored spectroscopically using Thioflavin-T. Embodiments of the invention then utilize a survival curve analysis to ascertain the relative physical stability of the different protein formulations under study. This method was used to develop novel surfactant-stabilized insulin formulations in a rapid, cost efficient manner, thus illustrating the utility of the inventive method to the discovery and development of pharmaceutical protein formulations.

US Patent:

7647237, Jan 12, 2010

Filed:

Jun 26, 2002

Appl. No.:

10/180732

Inventors:

Luis J. Malave - Valencia CA, US
Mark C. Estes - Simi Valley CA, US
Jay Yonemoto - Diamond Bar CA, US
J. Jeffrey Barlow - Valencia CA, US
Todd M. Gross - Saugus CA, US
John Shin - Glendale CA, US
Mike Dobbles - Burbank CA, US
Clifford W. Hague - Sherman Oaks CA, US
Deborah Ruppert - Los Angeles CA, US
Kevin C. Wells - Santa Monica CA, US

Assignee:

MiniMed, Inc. - Sylmar CA

International Classification:

A61B 5/00

US Classification:

705 3, 600300, 600309, 600347, 514 12, 604151, 6048901, 604207, 128897, 700214

Abstract:

A communication station is for use with a medical device (such as an infusion pump) and a processing device (such as a computer). The communication station includes a housing, a medical device interface coupled to the housing, a processing device interface coupled to the housing and a processor coupled to the housing. The device interface interfaces with the medical device, and the processing device interface interfaces with the processing device. The processor provides a communication path between the medical device and the processing device such that programming and instructions may be communicated from the processing device to the medical device and data may be transferred from the medical device to the processing device. The communication station may be combined with a system that is capable of generating reports either locally or remotely. In addition, the medical device interface may be a cradle that is configurable to attach to different shaped medical devices.

US Patent:

8521558, Aug 27, 2013

Filed:

Oct 5, 2011

Appl. No.:

13/253289

Inventors:

Luis J. Malave - Valencia CA, US
Mark C. Estes - Simi Valley CA, US
Jay Yonemoto - Diamond Bar CA, US
J. Jeffrey Barlow - Valencia CA, US
Todd M. Gross - Saugus CA, US
John Shin - Glendale CA, US
Mike Dobbles - Burbank CA, US
Clifford W. Hague - Sherman Oaks CA, US
Deborah Ruppert - Los Angeles CA, US
Kevin C. Wells - Santa Monica CA, US

Assignee:

Medtronic MiniMed, Inc. - Northridge CA

International Classification:

G06Q 10/00

US Classification:

705 2, 364413

Abstract:

A communication station is for use with a medical device (such as an infusion pump) and a processing device (such as a computer). The communication station includes a housing, a medical device interface coupled to the housing, a processing device interface coupled to the housing and a processor coupled to the housing. The device interface interfaces with the medical device, and the processing device interface interfaces with the processing device. The processor provides a communication path between the medical device and the processing device such that programming and instructions may be communicated from the processing device to the medical device and data may be transferred from the medical device to the processing device. The communication station may be combined with a system that is capable of generating reports either locally or remotely. In addition, the medical device interface may be a cradle that is configurable to attach to different shaped medical devices.

US Patent:

20050009735, Jan 13, 2005

Filed:

Apr 30, 2004

Appl. No.:

10/837289

Inventors:

Seonyoung Kim - Winnetka CA, US
William Van Antwerp - Valencia CA, US
Todd Gross - Saugus CA, US
Poonam Gulati - La Canada CA, US

International Classification:

A61K038/28

US Classification:

514003000

Abstract:

Embodiments of the invention are directed to a method of estimating the physical stability of a protein formulation. A particular embodiment of the invention places the protein formulation under an agitational stress that causes the protein to aggregate at an accelerated rate. In one embodiment, the change in protein aggregation is monitored spectroscopically using Thioflavin-T. Embodiments of the invention then utilize a survival curve analysis to ascertain the relative physical stability of the different protein formulations under study. This method was used to develop novel surfactant-stabilized insulin formulations in a rapid, cost efficient manner, thus illustrating the utility of the inventive method to the discovery and development of pharmaceutical protein formulations.

US Patent:

20080249470, Oct 9, 2008

Filed:

Jun 16, 2008

Appl. No.:

12/140157

Inventors:

Luis J. Malave - Valencia CA, US
Mark C. Estes - Simi Valley CA, US
Jay Yonemoto - Diamond Bar CA, US
J. Jeffrey Barlow - Valencia CA, US
Todd M. Gross - Saugus CA, US
John Shin - Glendale CA, US
Paul S. Cheney - Winnetka CA, US
Mike Dobbles - Burbank CA, US
Clifford W. Hague - Sherman Oaks CA, US
Deborah Ruppert - Los Angeles CA, US
Kevin C. Wells - Santa Monica CA, US

International Classification:

A61M 1/00

US Classification:

604151

Abstract:

A communication station is for use with a medical device (such as an infusion pump) and a processing device (such as a computer). The communication station includes a housing, a medical device interface coupled to the housing, a processing device interface coupled to the housing and a processor coupled to the housing. The device interface interfaces with the medical device, and the processing device interface interfaces with the processing device. The processor provides a communication path between the medical device and the processing device such that programming and instructions may be communicated from the processing device to the medical device and data may be transferred from the medical device to the processing device. The communication station may be combined with a system that is capable of generating reports either locally or remotely. In addition, the medical device interface may be a cradle that is configurable to attach to different shaped medical devices.

US Patent:

20170119794, May 4, 2017

Filed:

Nov 4, 2016

Appl. No.:

15/344489

Inventors:

- Calabasas CA, US
Elisabeth Sandoval - Calabasas CA, US
Nancy Jorgesen - Calabasas CA, US
Serge Lichtsteiner - Calabasas CA, US
Paul Lizzul - Calabasas CA, US
Todd Gross - Calabasas CA, US
Christine Somogyi - Calabasas CA, US

Assignee:

Kythera Biopharmaceuticals, Inc. - Calabasas CA

International Classification:

A61K 31/575
A61K 47/10

Abstract:

Provided herein are methods of treating a variety of disorders related to fat accumulation in humans with pharmaceutical formulations containing deoxycholic acid.