Jeffrey Chisholm - Mountain View CA, US Dmitry Koltun - Foster City CA, US Jeff Zablocki - San Mateo CA, US Eric Parkhill - San Francisco CA, US Andrey Glushkov - Moscow, RU Natalya Vasilevich - Moscow, RU Timur Zilbershtein - Kazan, RU Andrew Cole - Robbinsville NJ, US Tsung Lin - Princeton NJ, US Ian Henderson - Hopewell NJ, US
The present invention discloses pteridinone derivatives for use as inhibitors of stearoyl-CoA desaturase having the structure of Formula I:The compounds are useful in treating and/or preventing various human diseases, mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases related to abnormal lipid levels, cardiovascular disease, diabetes, obesity, metabolic syndrome and the like.
Pteridinone Derivatives For Use As Stearoyl Coa Desaturase Inhibitors
Jeffrey Chisholm - Mountain View CA, US Dmitry Koltun - Foster City CA, US Jeff Zablocki - Los Altos CA, US Eric Parkhill - San Francisco CA, US Andrey Glushkov - Moscow, RU Natalya Vasilevich - Moscow, RU Timur Zilbershtein - Tomsk, RU Andrew Cole - Robbinsville NJ, US Tsung Lin - Princeton NJ, US Ian Henderson - Hopewell NJ, US
The present invention discloses pteridinone derivatives for use as inhibitors of stearoyl-CoA desaturase having the structure of Formula I:The compounds are useful in treating and/or preventing various human diseases, mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases related to abnormal lipid levels, cardiovascular disease, diabetes, obesity, metabolic syndrome and the like.