Vasilis Zissis Marmarelis

US Patent:

6697657, Feb 24, 2004

Filed:

Jun 28, 2000

Appl. No.:

09/605176

Inventors:

Vasilis Z. Marmarelis - Irvine CA
Warren S. Grundfest - Los Angeles CA

Assignee:

Cedars-Sinai Medical Center - Los Angeles CA

International Classification:

A61B 500

US Classification:

600323, 600317, 600329

Abstract:

Methods and devices for Laser Induced Fluorescence Attenuation Laser Induced Fluorescence Attenuation Spectroscopy (LIFAS) Spectrocopy, including, in particular, methods and devices for the detection of ischemia and hypoxia in biological tissue. The LIFAS method and apparatus preferably include a source adapted to emit radiation that is directed at a sample volume in a sample to produce return light from the sample, such return light including modulated return light resulting from modulation by the sample, a first sensor, displaced by a first distance from the sample volume for monitoring the return light and generating a first signal indicative of the intensity of return light, a second sensor, displaced by a second distance from the sample volume for monitoring the return light and generating a second signal indicative of the intensity of return light, and a processor associated with the first sensor and the second sensor and adapted to process the first and second signals so as to determine the modulation of the sample. The methods and devices of the inventions are particularly well-suited for determining the wavelength-dependent attenuation of a sample and using the attenuation to restore the intrinsic laser induced fluorescence of the sample. In turn, the attenuation and intrinsic laser induced fluorescence can be used to determined a characteristic of interest, such as the ischemic or hypoxic condition of biological tissue.

US Patent:

6776760, Aug 17, 2004

Filed:

Mar 5, 2003

Appl. No.:

10/382235

Inventors:

Vasilis Z. Marmarelis - Irvine CA

Assignee:

Alfred E. Mann Institute for Biomedical Engineering at the University of Southern California - Los Angeles CA

International Classification:

A61B 802

US Classification:

600448

Abstract:

Systems and methods for obtaining images of body organs or other tissue for each of their multiple characterizing aspects, and for classifying different tissue types within the images according to their characterizing aspects, are disclosed herein. The tissue may be irradiated with an ultrasonic signal, and an interaction signal received in return. Sinogram data may be constructed from the received interaction signal, and multiple characterizing data extracted therefrom. The multiple characterizing data representing multiple characterizing aspects may then be matched to tissue type within a database containing information correlating characterizing multi-aspect data with tissue type. Images of the tissue may then be presented with identifiers associating tissue portions with their matched tissue types.

US Patent:

7094205, Aug 22, 2006

Filed:

Apr 5, 2002

Appl. No.:

10/117763

Inventors:

Vasilis Z. Marmarelis - Irvine CA, US

Assignee:

Alfred E. Mann Institute for Biomedical Engineering at the University of Southern California - Los Angeles CA

International Classification:

A61B 8/02

US Classification:

600448

Abstract:

A system for providing high resolution imaging of objects having sub-millimeter dimensions comprised of at least one transmitter, at least one receiver, a coupling chamber, and a processor for recording attenuation and time of flight profiles of the transmitted signals. The signals are conditioned in a manner to provide high signal-to-noise ration (SNR) and minimal crosstalk and multipath effects at the receiver.

US Patent:

RE39672, Jun 5, 2007

Filed:

Jan 23, 2002

Appl. No.:

10/056335

Inventors:

Vasilis Z. Marmarelis - Irvine CA, US
Warren S. Grundfest - Calabasas CA, US

Assignee:

Cedars-Sinai Medical Center - Los Angeles CA

International Classification:

G01N 21/64

US Classification:

2504612, 2504581, 600321, 600320, 600323, 356342

Abstract:

The Laser Induced Fluorescence Attenuation Spectroscopy (LIFAS) method and apparatus preferably include a source adapted to emit radiation that is directed at a sample volume in a sample to produce return light from the sample, such return light including modulated return light resulting from modulation by the sample, a first sensor, displaced by a first distance from the sample volume for monitoring the return light and generating a first signal indicative of the intensity of return light, a second sensor, displaced by a second distance from the sample volume, for monitoring the return light and generating a second signal indicative of the intensity of return light, and a processor associated with the first sensor and the second sensor and adapted to process the first and second signals so as to determine the modulation of the sample. The methods and devices of the inventions are particularly well-suited for determining the wavelength-dependent attenuation of a sample and using the attenuation to restore the intrinsic laser induced fluorescence of the sample. In turn, the attenuation and intrinsic laser induced fluorescence can be used to determined a characteristic of interest, such as the ischemic or hypoxic condition of biological tissue.

US Patent:

8463582, Jun 11, 2013

Filed:

Jun 9, 2008

Appl. No.:

12/135904

Inventors:

Dong Song - Irvine CA, US
Vasilis Z. Marmarelis - Rancho Palos Verdes CA, US
Theodore W. Berger - Rancho Palos Verdes CA, US

Assignee:

University of Southern California - Los Angeles CA

International Classification:

G06F 17/10

US Classification:

703 2

Abstract:

Systems and techniques, including machine-readable instructions, for modeling of nonlinear systems. In one aspect, an apparatus includes a collection of two or more inputs configured and arranged to receive input signals, a collection of two or more outputs configured and arranged to output output signals, a processing unit configured to transform the input signals into the output signals, wherein the transformation is non-linear and treats the non-linear system as a collection of multiple input, single output non-linear systems, and a data storage that stores characteristics of the transformation.

US Patent:

20020186893, Dec 12, 2002

Filed:

Apr 5, 2002

Appl. No.:

10/117468

Inventors:

Vasilis Marmarelis - Irvine CA, US

International Classification:

G06K009/40
G06T005/00

US Classification:

382/260000, 382/131000, 382/275000

Abstract:

A combined linear filtering with nonlinear processing that can process the received data to reduce errors due to the effects of diffraction of a signal about an object. The method achieves this with high efficiency (near real-time). This processing operator has a specific computational form with a set of parameters that can be selected appropriately in each give application.

US Patent:

20040064047, Apr 1, 2004

Filed:

Jul 18, 2003

Appl. No.:

10/623426

Inventors:

Vasilis Marmarelis - Irvine CA, US

International Classification:

A61B008/00

US Classification:

600/437000

Abstract:

A process for optimizing the excitation waveform that is delivered to a transmitter that, together with a receiver, form part of a nonlinear transmission and reception system. The process may include delivering a transmission test signal to the transmitter, generating a receive test signal from the receiver that is a nonlinear function of the transmission test signal, developing a nonlinear model of the nonlinear function, and determining an optimum excitation signal based on the model. An application to ultrasonic imaging for breast mammography is also disclosed.

US Patent:

20040082856, Apr 29, 2004

Filed:

Jul 16, 2003

Appl. No.:

10/620739

Inventors:

Vasilis Marmarelis - Irvine CA, US

Assignee:

Alfred E. Mann Institute for Biomedical Engineering, University of Southern California

International Classification:

A61B008/00

US Classification:

600/437000

Abstract:

A receptacle for supporting a breast during ultrasonic scanning. The receptacle may include a contoured cup made of material that is substantially transparent to acoustical energy and have an open end into which the breast may be inserted and a narrowed end to receive a nipple of the breast. The receptacle may include spaced-apart elongated members, each made of material that is not substantially transparent to acoustical energy and each being mechanically coupled to the open end and to the narrow end of the cup. A fluid pump, impedance matching and a contoured tabletop are also disclosed.