Vivian C Lee

US Patent:

6525176, Feb 25, 2003

Filed:

Jul 7, 2000

Appl. No.:

09/612592

Inventors:

Vivian W. Lee - Alamo CA
Kris P. Antonsen - Berkeley CA

Assignee:

PPL (Holdings) Limited - London

International Classification:

C07K 100

US Classification:

530350, 530413, 530416, 530380, 530392, 530395, 530830

Abstract:

A method for purifying human or other alpha-l proteinase inhibitor ( -PI) from a solution (which may be derived from the milk of a transgenic animal expressing the -PI) which comprises contacting the solution with a cation exchange substrate under conditions sufficient to bind non-tg- -PI contaminants to the substrate while not substantially binding tg -PI to the substrate. Using the preferred embodiment, the purified tg -PI contains as little as 40 pg non- -PI-whey protein per mg total protein.

US Patent:

61945536, Feb 27, 2001

Filed:

Mar 9, 1998

Appl. No.:

9/036796

Inventors:

Vivian W. Lee - Alamo CA
Kris P. Antonsen - Berkeley CA

Assignee:

PPL Therapeutics (Scotland) Limited - Edinburgh

International Classification:

C07K 118
C07K 122

US Classification:

530413

Abstract:

A method for purifying human or other alpha-1 proteinase inhibitor (. alpha. sub. 1 -PI) from a solution (which may be derived from the milk of a transgenic animal expressing the. alpha. sub. 1 -PI) which comprises contacting the solution with a cation exchange substrate under conditions sufficient to bind non-tg-. alpha. sub. 1 -PI contaminants to the substrate while not substantially binding tg. alpha. sub. 1 -PI to the substrate. Using the preferred embodiment, the purified tg. alpha. sub. 1 -PI contains as little as 40 pg non-. alpha. sub. 1 -PI-whey protein per mg total protein.

US Patent:

56587465, Aug 19, 1997

Filed:

Nov 3, 1995

Appl. No.:

8/552432

Inventors:

Michael H. Coan - El Cerrito CA
Cynthia J. Galloway - Emeryville CA
Vivian W. Lee - Richmond CA

Assignee:

Bayer Corporation - Berkeley CA

International Classification:

G01N 33567
G01N 33566
G01N 33531
G01N 3353

US Classification:

435 724

Abstract:

A method of controlling the amount of a biologically active substance binding to a cell surface having both receptors to the substance and receptors for the Fc domain of an antibody that can complex with the substance or other antibodies that can complex with the substance. By exploiting the generally more numerous Fc receptor sites, substance binding can be increased and/or controlled. Method contemplates controlling amounts of substances such as cytokines, hormones, and growth factors that are associated with cells such as monocytes, macrophages, granulocytes, B cells, T cells, and platelets. Method is illustrated using conjugated antibodies to tissue necrosis factor (TNF) to increase the binding of TNF to monocytes.

US Patent:

51109131, May 5, 1992

Filed:

May 25, 1990

Appl. No.:

7/528523

Inventors:

Michael Coan - El Cerrito CA
Vivian W. Lee - Richmond CA

Assignee:

Miles Inc. - Elkhart IN

International Classification:

C07K 312
C07K 322

US Classification:

53038823

Abstract:

Method of purifying a protein from a solution of substances comprising the steps of passing the solution through an ion exchange material at a pH which facilitates binding of the protein of interest, washing the bound protein at a different pH at which the bound protein does not elute but which the free protein would not bind to the ion exchange material, and then eluting the protein at a pH which facilitates elution. Method is especially useful in purification of antibodies such as antibodies to tumor necrosis factor.

US Patent:

20230037296, Feb 9, 2023

Filed:

Oct 24, 2022

Appl. No.:

17/972285

Inventors:

- Burbank CA, US
David P. Min - Menlo Park CA, US
Alif Khalfan - Redwood City CA, US
Vivian S. Lee - Los Angeles CA, US

International Classification:

G06Q 20/12
G06Q 20/36
H04L 9/32

Abstract:

Systems and methods to manage digital asset functionality based on fulfillment of criteria are disclosed. Exemplary implementations may: receive, from a digital asset distribution platform, an indication that a user is requesting to acquire or acquired a collectible digital asset in a digital wallet of the user, the collectible digital asset is correlated with an entity; determine whether condition(s) are fulfilled; upon determination that the condition(s) are not fulfilled, prevent the acquisition of the collectible digital asset by the digital wallet or restrict a set of rights to the correlated entity; and upon determination that the condition(s) are fulfilled, permit acquisition of the collectible digital asset or permit the set of rights.

US Patent:

20160184724, Jun 30, 2016

Filed:

Aug 27, 2015

Appl. No.:

14/838307

Inventors:

Andrew Butler - Palo Alto CA, US
Tom Boeckle - Las Vegas NV, US
F Brian Iannce - San Jose CA, US
Vivian Lee - Sunnyvale CA, US

International Classification:

A63H 29/22

Abstract:

An app programming environment that enables a smartphone or tablet app to incorporate real toys or objects into the app, by use of a NFC chip located in the toy or object and a database comprising information regarding the toy or object used.

US Patent:

20150038897, Feb 5, 2015

Filed:

Jul 30, 2014

Appl. No.:

14/447309

Inventors:

- Fremont CA, US
Cedric Wright - Mountain View CA, US
Matt Vargas - San Jose CA, US
Vivian Lee - Sunnyvale CA, US
Jessica Heasley - Mountain View CA, US

International Classification:

A61M 37/00

US Classification:

604 46

Abstract:

A low-profile applicator, and a method of manufacturing and use thereof, for impacting microneedles against the stratum corneum of a person having a housing, a diaphragm member having the microneedles, a folding member having interlinking members that hinge-ably rotate with a force member, operatively attached thereto, between a resting position and an extended position. The folding member translates energy stored within the force member when release while retaining the force member in an energized state when in the resting position.