Wei S Li

US Patent:

6984735, Jan 10, 2006

Filed:

Nov 26, 2003

Appl. No.:

10/722782

Inventors:

John C. McKew - Arlington MA, US
Steven Y. Tam - Wellesley MA, US
Katherine L. Lee - West Newton MA, US
Lihren Chen - Cambridge MA, US
Paresh Thakker - Boston MA, US
Fuk-Wah Sum - Pomona NY, US
Mark Behnke - Sommerville MA, US
Baihua Hu - Audubon PA, US
James D. Clark - Acton MA, US
Wei Li - Acton MA, US

Assignee:

Wyeth - Madison NJ

International Classification:

C07D 215/38
C07D 217/12

US Classification:

544334, 546146, 546169, 546315, 548194, 548236, 548248, 568316

Abstract:

A process for making an aromatic aldehyde in which a sulfoxide is reacted with a dihalogenated aromatic compound in the absence of an effective amount of an activating reagent. The aldehyde may then be used to make other compounds, such as a compound that acts as a cPLA inhibitor.

US Patent:

7571159, Aug 4, 2009

Filed:

Feb 1, 2006

Appl. No.:

11/344193

Inventors:

Shiby Thomas - Nashua NH, US
Wei Li - San Carlos CA, US
Joseph Yarmus - Groton MA, US
Mahesh Jagannath - Shrewsbury MA, US
Ari W. Mozes - Lexington MA, US

Assignee:

Oracle International Corporation - Redwood Shores CA

International Classification:

G06F 7/00
G06F 17/30
G06F 17/00

US Classification:

707 3, 7071041

Abstract:

A method, system, and computer program product for counting predictor-target pairs for a decision tree model provides the capability to generate count tables that is quicker and more efficient than previous techniques. A method of counting predictor-target pairs for a decision tree model, the decision tree model based on data stored in a database, the data comprising a plurality of rows of data, at least one predictor and at least one target, comprises generating a bitmap for each split node of data stored in a database system by intersecting a parent node bitmap and a bitmap of a predictor that satisfies a condition of the node, intersecting each split node bitmap with each predictor bitmap and with each target bitmap to form intersected bitmaps, and counting bits of each intersected bitmap to generate a count of predictor-target pairs.

US Patent:

7605156, Oct 20, 2009

Filed:

May 27, 2005

Appl. No.:

11/140390

Inventors:

John C. McKew - Arlington MA, US
Steve Y. Tam - Wellesley MA, US
Katherine L. Lee - West Newton MA, US
Lihren Chen - Cambridge MA, US
Paresh Thakker - Boston MA, US
Fuk-Wah Sum - Pomona NY, US
Mark L. Behnke - Somerville MA, US
Baihua Hu - Audubon PA, US
James D. Clark - Acton MA, US
Wei Li - Acton MA, US
Valerie Clerin - Watertown MA, US
Suzana Marusic - Reading MA, US
Kevin Pong - Robbinsville NJ, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31/54

US Classification:

5142282, 514374, 514375, 514381, 514386, 514406, 514414, 5142335, 51425409, 514256, 514365, 514339, 514345, 544 582, 544143, 544333, 544373, 546 16, 546201, 5462774, 546115

Abstract:

This invention provides methods for the use of substituted indole compounds of the general formula:.

US Patent:

7632838, Dec 15, 2009

Filed:

Feb 7, 2007

Appl. No.:

11/703522

Inventors:

Jason Shaoyun Xiang - Winchester MA, US
Eddine Saiah - Brookline MA, US
Steve Y. Tam - Wellesley MA, US
John C. Mckew - Arlington MA, US
Lihren Chen - Bedford MA, US
Manus Ipek - Watertown MA, US
Jianchang Li - Carlisle MA, US
Wei Li - Acton MA, US
Tarek Suhayl Mansour - New City NY, US
Vipin Suri - Waltham MA, US
Yuchuan Wu - Acton MA, US
Jinbo Lee - Andover MA, US
Eva Binnun - Boston MA, US
Douglas P. Wilson - Ayer MA, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31/4965
C07D 241/04
C07D 295/00

US Classification:

51425503, 544383

Abstract:

This invention relates to inhibiting 11βHSD1.

US Patent:

7906548, Mar 15, 2011

Filed:

Aug 11, 2009

Appl. No.:

12/539074

Inventors:

John C. McKew - Arlington MA, US
Steve Y. Tam - Wellesley MA, US
Katherine L. Lee - West Newton MA, US
Lihren Chen - Cambridge MA, US
Paresh Thakker - Boston MA, US
Fuk-Wah Sum - Pomona NY, US
Mark L. Behnke - Somerville MA, US
Baihua Hu - Audubon PA, US
James D. Clark - Acton MA, US
Wei Li - Acton MA, US
Valerie Clerin - Watertown MA, US
Suzana Marusic - Reading MA, US
Kevin Pong - Robbinsville NJ, US

Assignee:

Wyeth LLC - Madison NJ

International Classification:

A01N 43/38

US Classification:

514415

Abstract:

This invention provides methods for the use of substituted indole compounds of the general formula:.

US Patent:

8163736, Apr 24, 2012

Filed:

Jul 16, 2008

Appl. No.:

12/174195

Inventors:

Laurence Gauzy - Paris, FR
Herve Bouchard - Thiais, FR
Ravi V. J. Chari - Newton MA, US
Alain Commercon - Vitry-sur-Seine, FR
Robert Zhao - Lexington MA, US
Yonghong Deng - Arlington MA, US
Wei Li - Winchester MA, US

Assignee:

sanofi-aventis - Paris

International Classification:

C07D 519/00
C07D 487/00
A61K 31/5517

US Classification:

514220, 540496

Abstract:

The present invention is related to new tomaymycin derivatives, their process of preparation and their therapeutic uses.

US Patent:

8299106, Oct 30, 2012

Filed:

Sep 5, 2008

Appl. No.:

12/676869

Inventors:

Chiang Jia Li - Cambridge MA, US
Youzhi Li - Westwood MA, US
Wei Li - Wayland MA, US
Harry Rogoff - Wrentham MA, US

Assignee:

Boston Biomedical, Inc. - Norwood MA

International Classification:

A01N 43/78
A61K 31/425

US Classification:

514365

Abstract:

The present invention relates to novel thiazole-substituted indolin-2-ones as inhibitors of CSCPK and related kinases; to methods of inhibiting cancer stem cells by using a kinase inhibitor; to pharmaceutical compositions containing such compounds; and to methods of using such compounds in the treatment of a protein kinase related disorder in a mammal; and to processes of making such compounds and intermediates thereof.

US Patent:

8426402, Apr 23, 2013

Filed:

Feb 4, 2010

Appl. No.:

12/700131

Inventors:

Wei Li - Acton MA, US
Nathan Fishkin - Weymouth MA, US
Robert Zhao - Lexington MA, US
Michael Miller - Framingham MA, US
Ravi Chari - Newton MA, US

Assignee:

ImmunoGen, Inc. - Waltham MA

International Classification:

C07D 519/00
A61K 31/5517
A61K 31/55
A61P 35/00

US Classification:

514219, 540494

Abstract:

The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepines of formula (I) and (II), in which the diazepine ring (B) is fused with a heterocyclic ring (CD), wherein the heterocyclic ring is bicyclic or a compound of formula (III), in which the diazepine ring (B) is fused with a heterocyclic ring (C), wherein the heterocyclic ring is monocyclic. The invention provides cytotoxic dimers of these compounds. The invention also provides conjugates of the monomers and the dimers. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. The invention further relates to methods of using the compounds or conjugates for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.