Yan Wu

US Patent:

7400627, Jul 15, 2008

Filed:

Nov 7, 2003

Appl. No.:

10/702456

Inventors:

Yan Wu - Morganville NJ, US
Song Bi - Piscataway NJ, US
Timothy Bornemisza - Middletown NJ, US

Assignee:

Brooktree Broadband Holding, Inc. - Newport Beach CA

International Classification:

H04L 12/28
H04J 3/24

US Classification:

370392, 3703951, 370474

Abstract:

Disclosed are exemplary techniques for compressing ATM cells by substituting reduced headers for the original headers. A header table may be maintained at the transmitting end whereby headers are stored in table entries based on a table index generated from a hash function applied to the headers. A copy of the header table may be maintained at the receiving end and may be updated by populating idle cells with header table contents. Upon receipt of a reduced ATM cell at the receiving end, the reduced header may be replaced with a full header obtained from the copy of the header table maintained at the receiving end. The present invention further provides techniques for registration and management of hash collisions.

US Patent:

7720071, May 18, 2010

Filed:

Mar 5, 2008

Appl. No.:

12/042930

Inventors:

Yan Wu - Morganville NJ, US
Song Bi - Piscataway NJ, US
Timothy Bornemisza - Middletown NJ, US

Assignee:

Ikanos Communications, Inc. - Fremont CA

International Classification:

H04L 12/28
H04J 3/24

US Classification:

370392, 3703951, 370474

Abstract:

Disclosed are exemplary techniques for compressing ATM cells by substituting reduced headers for the original headers. A header table may be maintained at the transmitting end whereby headers are stored in table entries based on a table index generated from a hash function applied to the headers. A copy of the header table may be maintained at the receiving end and may be updated by populating idle cells with header table contents. Upon receipt of a reduced ATM cell at the receiving end, the reduced header may be replaced with a full header obtained from the copy of the header table maintained at the receiving end. The present invention further provides techniques for registration and management of hash collisions.

US Patent:

7813434, Oct 12, 2010

Filed:

Nov 14, 2006

Appl. No.:

11/559772

Inventors:

Yan Wu - Morganville NJ, US
Lujing Cai - Morganville NJ, US
William Scholtz - Red Bank NJ, US
Ehud Langberg - Wayside NJ, US

Assignee:

Ikanos Communications, Inc. - Fremont CA

International Classification:

H04K 1/10
H04L 27/28

US Classification:

375260

Abstract:

Systems and methods for performing bit loading in a dual latency data transmission system. In a computer network, such as an XDSL-based network, carrier channels are allocated between two latency paths. Error sensitive information is transmitted over a latency path employing one or more forward error correction techniques. Latency sensitive information that is relatively more tolerant of errors is transmitted over the other latency path. Rather than employing the lowest coding gain for carrier channels having the two different latency paths, the highest coding gain for each path is used by applying different target S-N-R margins for carrier channels having different latency paths.

US Patent:

20040247597, Dec 9, 2004

Filed:

Jun 30, 2004

Appl. No.:

10/482269

Inventors:

Peter Carmeliet - Landen, BE
Daniel Hicklin - Upper Montclair NJ, US
Fang Liao - New York City NY, US
Yan Wu - Flemington NJ, US
Aernout Luttun - Zwevezele, BE

International Classification:

A61K039/395
A61K038/17

US Classification:

424/145100, 514/012000

Abstract:

The present invention is directed to methods utilizing vascular endothelial growth factor receptor (VEGFR) antagonists to treat atherosclerosis and other inflammatory diseases.

US Patent:

20220235104, Jul 28, 2022

Filed:

Jul 3, 2019

Appl. No.:

17/257951

Inventors:

- Oakland CA, US
Yan Wu - La Jolla CA, US
Amir Dailamy - La Jolla CA, US
Prashant Mali - La Jolla CA, US
Daniella McDonald - La Jolla CA, US
Udit Parekh - La Jolla CA, US
Michael Hu - La Jolla CA, US

International Classification:

C07K 14/47
A61K 31/522
A61K 45/06
C12N 15/86
C12N 5/071
C12N 15/11
C12N 9/22

Abstract:

This disclosure relates to methods, polynucleotides, vectors, viral particles, cells, and systems or the engineering of human tissues. One aspect of the disclosure relates to using lineage-specific miRNA binding molecules to bias tissue lineage. Another aspect of the disclosure relates to using lineage-specific transcription factor overexpression to bias tissue lineage.

US Patent:

20210108193, Apr 15, 2021

Filed:

Sep 22, 2020

Appl. No.:

17/028836

Inventors:

- Oakland CA, US
Udit Parekh - La Jolla CA, US
Yan Wu - La Jolla CA, US
Kun Zhang - La Jolla CA, US

International Classification:

C12N 15/10
C12N 5/071
C12N 15/86
A61K 35/44

Abstract:

Understanding the complex effects of genetic perturbations on cellular state and fitness in human pluripotent stem cells (hPSCs) has been challenging using traditional pooled screening techniques which typically rely on unidimensional phenotypic readouts. Here, Applicants use barcoded open reading frame (ORF) overexpression libraries with a coupled single-cell RNA sequencing (scRNA-seq) and fitness screening approach, a technique we call SEUSS (ScalablE fUnctional Screening by Sequencing), to establish a comprehensive assaying platform. Using this system, Applicants perturbed hPSCs with a library of developmentally critical transcription factors (TFs), and assayed the impact of TF overexpression on fitness and transcriptomic cell state across multiple media conditions. Applicants further leveraged the versatility of the ORF library approach to systematically assay mutant gene libraries and also whole gene families. From the transcriptomic responses, Applicants built genetic co-perturbation networks to identify key altered gene modules. Strikingly, we found that KLF4 and SNAI2 have opposing effects on the pluripotency gene module, highlighting the power of this method to characterize the effects of genetic perturbations. From the fitness responses, Applicants identified ETV2 as a driver of reprogramming towards an endothelial-like state.

US Patent:

20210022773, Jan 28, 2021

Filed:

Mar 9, 2020

Appl. No.:

16/812867

Inventors:

- NEW YORK NY, US
Zhenping Zhu - Woodcliff Lake NJ, US
Yan Wu - Doylestown PA, US
Stella A. Martomo - Edgewater NJ, US
Zhaojing Zhong - Bronx NY, US
Dan Lu - Montvale NJ, US

International Classification:

A61B 17/70

Abstract:

The invention provides antibodies that specifically bind to PD-L1 and fusion molecules comprising PD-L1 binding proteins constructed with an IL 15 receptor-binding domain, nucleic acid molecules encoding the same, and therapeutic compositions thereof. The agents inhibit PD-L1-mediated immunosuppression and enhance cell and cytokine mediated immunity for the treatment of neoplastic and infectious diseases.

US Patent:

20190330661, Oct 31, 2019

Filed:

Jun 28, 2017

Appl. No.:

16/312907

Inventors:

- Oakland CA, US
Prashant MALI - La Jolla CA, US
Yan WU - La Jolla CA, US
Dongxin ZHAO - La Jolla CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C12N 15/90
C12N 15/10
C12N 9/22
G16B 20/20
G16B 25/10
G16B 40/10
C12N 15/113

Abstract:

A guide RNA comprising: a gRNA spacer sequence at the 5′ end of the guide RNA, wherein the spacer sequence is complementary to a target gene, a scaffold sequence that binds to Cas9, and an RNA capture and sequencing domain comprising: a barcode sequence, and a primer binding sequence; nucleic acids and vectors encoding the guide RNA; cells expressing the guide RNA; and a library comprising a plurality of guide RNAs. Also disclosed are methods of introducing a genetic perturbation into a cell, methods of assessing an effect of at least one genetic perturbation on RNA expression in a cell, methods of identifying nucleic acid sequences associated with a disease state and a method of identifying candidate therapeutic agents.