Ying Song

US Patent:

20140274988, Sep 18, 2014

Filed:

Mar 13, 2014

Appl. No.:

14/209089

Inventors:

- Cambridge MA, US
Ying Song - Cambridge MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

C07F 15/00

US Classification:

514186, 549211

Abstract:

Methods, compounds, and compositions for treating a proliferative disorder or other physiological conditions via a dual targeting anticancer therapy are provided. In some embodiments, a dual targeting anticancer therapy may utilize a composition comprising a platinum agent. The platinum agent may comprise a precursor to a therapeutically active platinum compound and at least one precursor to a vitamin E agent. The vitamin E agent may target cancer cells via a different mechanism of action than the therapeutically active platinum compound resulting in a dual targeting anticancer agent. The method of treatment may involve administering to a patient the dual targeting anticancer agent. Following administration, a therapeutically active platinum compound and a vitamin E agent may form at the physiologically relevant site. In some embodiments, administering a platinum agent comprising precursors of therapeutically active agents may be more effective than individually or simultaneously administering separate molecules of those therapeutically active agents.

US Patent:

20050100876, May 12, 2005

Filed:

Aug 25, 2003

Appl. No.:

10/646802

Inventors:

Bijan Khirabadi - Rockville MD, US
Ying Song - Mt. Pleasant SC, US
Kelvin Brockbank - Charleston SC, US

Assignee:

ORGAN RECOVERY SYSTEMS, INC. - Des Plaines IL

International Classification:

A01N001/02

US Classification:

435001100

Abstract:

A method for vitrification of a tissue or organ includes immersing the tissue or organ in increasing concentrations of cryoprotectant solution at a temperature greater than −15 C. to a cryoprotectant concentration sufficient for vitrification; cooling the tissue or organ at an average rate of from 2.5-100 C. per minute to a temperature between −80 C. and the glass transition temperature; and further cooling the tissue or organ at an average rate less than 30 C. per minute to a temperature below the glass transition temperature to vitrify the tissue or organ. After the vitrified tissue or organ has been stored, the tissue or organ may be removed from vitrification by warming the tissue or organ at an average rate of from 20-40 C. per minute to a temperature between −80 C. and the glass transition temperature; further warming the tissue or organ at a rate greater than 80 C. per minute to a temperature above −75 C.; and reducing the concentration of the cryoprotectant. Tissues or organs treated in this manner exhibit near normal functions, for example, blood vessels exhibit near normal smooth muscle contractility and normal graft functions.