Yong Moon Choi

US Patent:

6627211, Sep 30, 2003

Filed:

Jul 24, 2000

Appl. No.:

09/624305

Inventors:

Yong Moon Choi - Towaco NJ
Lianli Li - Fresh Meadows NY
Kwon H. Kim - Bridgewater NJ

Assignee:

SK Corporation

International Classification:

A61F 1300

US Classification:

424434, 424 45, 514 78, 514975

Abstract:

A method of vehicle modulated administration of an anticonvulsive agent to the nasal mucous membranes of humans and animals is disclosed. The vehicle system is an aqueous pharmaceutical carrier comprising an aliphatic alcohol, a glycol and a biological surfactant such as a bile salt or a lecithin. The pharmaceutical composition provides a means to control and promote the rate and extent of transmucosal permeation and absorption of the medicaments via a single and multiple administration. Nasal administration of the pharmaceutical preparation produces a high plasma concentration of the anticonvulsant nearly as fast as intravenous administration. Such compositions are particularly suitable for a prompt and timely medication of patients in the acute and/or emergency treatment of status epilepticus and other fever-induced seizures.

US Patent:

7132112, Nov 7, 2006

Filed:

Aug 5, 2003

Appl. No.:

10/634689

Inventors:

Yong Moon Choi - Towaco NJ, US
Lianli Li - Fresh Meadows NY, US
Kwon H. Kim - Bridgewater NJ, US

Assignee:

SK Corporation

International Classification:

A61F 13/00
A61L 9/04

US Classification:

424434, 424 45

Abstract:

A novel method of vehicle modulated administration of an anticonvulsive agent to the mucous membranes of humans and animals is disclosed. The vehicle system is an aqueous pharmaceutical carrier comprising an aliphatic alcohol (10–80%) or a glycol (10–80%), and their combinations with a biological surfactant such as a bile salt or a lecithin. The pharmaceutical composition provides a means to control and promote the rate and extent of transmucosal permeation and absorption of the medicaments via a single and multiple administration. Nasal administration of the pharmaceutical preparation produces a high plasma concentration of the anticonvulsant nearly as fast as intravenous administration. Such compositions are particularly suitable for a prompt and timely medication of patients in the acute and/or emergency treatment of status epilepticus and other fever-induced seizures.

US Patent:

7446127, Nov 4, 2008

Filed:

Aug 26, 2004

Appl. No.:

10/926615

Inventors:

Yong Moon Choi - Pine Brook NJ, US
Hunwoo Shin - Livingston NJ, US
Palanichamy Ilankumaran - Pinerbrook NJ, US
Hong Wook Kim - Lincoln Park NJ, US

Assignee:

SK Holdings Co, Ltd. - Seoul

International Classification:

A01N 43/16
C07D 263/30

US Classification:

514458, 548235

Abstract:

There are disclosed derivatives of 3-chromancarboxylic acid represented by formula I.

US Patent:

7456293, Nov 25, 2008

Filed:

Mar 28, 2006

Appl. No.:

11/391031

Inventors:

Yong Moon Choi - Pinebrook NJ, US
Hunwoo Shin - Livingston NJ, US
Palanichamy Ilankumaran - Pinebrook NJ, US

Assignee:

SK Holding Co., Ltd - Seoul

International Classification:

A61K 31/4184
C07D 235/04

US Classification:

5483101, 514394

Abstract:

The present invention is concerned with racemic or enantiomerically enriched substituted carboxylic acids and derivatives thereof represented by Formula 1;.

US Patent:

7598279, Oct 6, 2009

Filed:

Apr 20, 2006

Appl. No.:

11/407526

Inventors:

Yong Moon Choi - Pinebrook NJ, US
Choon-Gil Kim - Daejon, KR
Han-Ju Yi - Daejeon, KR
Young-Sun Kang - Daejeon, KR
Hyun-Seok Lee - Daejeon, KR

Assignee:

SK Holdings Co., Ltd. - Seoul

International Classification:

A61K 31/445
C07D 401/12
C07D 249/08
C07D 249/04

US Classification:

514359, 514281, 514283, 548250, 548255, 5482622

Abstract:

Azole compounds containing carbamoyl group and pharmaceutically useful salts thereof are described. The compounds are effective anticonvulsants which are used in the treatment of disorders of the central nervous system, especially as anxiety, depression, convulsion, epilepsy, migraine, bipolar disorder, drug abuse, smoking, ADHD, obesity, sleep disorder, neuropathic pain, stroke, cognitive impairment, neurodegeneration, stroke and muscle spasm.

US Patent:

20010034365, Oct 25, 2001

Filed:

Jan 31, 2001

Appl. No.:

09/774736

Inventors:

Yong Choi - Towaco NJ, US
Min Kim - Montvale NJ, US
Jeonghan Park - Flanders NJ, US

International Classification:

C07C271/08
A61K031/27

US Classification:

514/483000, 560/026000

Abstract:

Enantiomeric forms of monocarbamates of halogenated 2-pheny-1,2 -ethanediol and dicarbamates of halogenated 2-pheny-1,2-ethanediol have been found to be effective in the treatment of disorders of the central nervous system, especially as anti-convulsive or anti-epileptic agents.

US Patent:

20050002987, Jan 6, 2005

Filed:

Jun 16, 2004

Appl. No.:

10/869195

Inventors:

Yong Moon Choi - Pine Brook NJ, US
Kwon Kim - Palisades Park NJ, US

International Classification:

A61K009/70
A61K009/14

US Classification:

424434000, 424489000

Abstract:

Diazepam is administered intranasally in the form of specific microemulsions having advantageous properties. The microemulsions are comprised of about equal quantities of a fatty acid and water with the remainder being a hydrophilic surfactant, a polar solvent and an alcohol in a weight ratio such that alcohol is present in a greater quantity by weight than either of the other two. Nasal administration of the subject microemulsions produces a high plasma concentration of diazepam nearly as fast as intravenous administration. The present microemulsions are particularly suitable for a prompt and timely treatment of patients in the acute and/or emergency treatment of status epilepticus and other fever-induced seizures.

US Patent:

20060058548, Mar 16, 2006

Filed:

Nov 3, 2005

Appl. No.:

11/266555

Inventors:

Yong Choi - Pine Brook NJ, US
Min Kim - Montville NJ, US

International Classification:

C07D 217/12

US Classification:

560157000, 546146000

Abstract:

A process for preparing O-carbamoyl aminoalcohols represented by Formula I wherein: n is an integer from 0 and 5;