Yu Ping Yang

US Patent:

20110286979, Nov 24, 2011

Filed:

May 19, 2011

Appl. No.:

13/111677

Inventors:

Alex W. Tong - Dallas TX, US
Yu Yang - Allen TX, US
Donald Rao - Dallas TX, US
Phillip B. Maples - Pilot Point TX, US
Neil Senzer - Dallas TX, US
John J. Nemunaitis - Cedar Hill TX, US
Zhaohui Wang - Grapevine TX, US

Assignee:

GRADALIS, INC. - Carrollton TX

International Classification:

A61K 35/12
A61K 31/7105
A61K 31/7088
A61P 35/00
A61P 35/04

US Classification:

424 9321, 514 44 R, 514 44 A

Abstract:

Compositions and methods of augmenting the anti-tumor activities of docetaxel and other taxanes by combination with a bi-functional small hairpin RNA (bi-shRNA) is described herein. The instant invention describes the interactive outcome of STMN1 knockdown with docetaxel. In vitro docetaxel (DOC) dose response assessments with or without co-treatment with bi-shRNAin CCL-247 and SK-MEL-28 melanoma cells indicated that STMN1 knockdown significantly reduced DOC concentration needed to inhibit cancer cell growth by 50% (IC) of CCL-247 cells from 1.80.2 to 0.60.4 nm (n=3, p