Yuan P Chen

US Patent:

7514998, Apr 7, 2009

Filed:

Dec 7, 2006

Appl. No.:

11/636365

Inventors:

Mohammad Mojarradi - La Canada CA, US
Greg Levanas - Costa Mesa CA, US
Yuan Chen - Pasadena CA, US
Raymond S. Cozy - Altadena CA, US
Robert Greenwell - Knoxville TN, US
Stephen Terry - Knoxville TN, US
Benjamin J. Blalock - Knoxville TN, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

H03F 3/45
H01L 35/00
G05F 3/02

US Classification:

330256, 327513, 327539

Abstract:

The present invention relates to a reference current circuit. The reference circuit comprises a low-level current bias circuit, a voltage proportional-to-absolute temperature generator for creating a proportional-to-absolute temperature voltage (VPTAT), and a MOSFET-based constant-IC regulator circuit. The MOSFET-based constant-IC regulator circuit includes a constant-IC input and constant-IC output. The constant-IC input is electrically connected with the VPTAT generator such that the voltage proportional-to-absolute temperature is the input into the constant-IC regulator circuit. Thus the constant-IC output maintains the constant-IC ratio across any temperature range.

US Patent:

20120302815, Nov 29, 2012

Filed:

Feb 21, 2012

Appl. No.:

13/401642

Inventors:

Yuan Chen - Arcadia CA, US
David Horne - Duarte CA, US
Yuelong Ma - Duarte CA, US
Yang Su - Beijing, CN

International Classification:

C07F 1/12
A61L 2/08
A61M 37/00
C12N 5/09

US Classification:

600 1, 556117, 435375, 422 22

Abstract:

A composition used to develop a reagent for investigating Ubl-modifications in cellular functions and in the treatment of cancer is provided. The composition comprises gold nanoparticle (AuNP)-ligand conjugates that include at least two components: gold nanoparticles (AuNPs) and modified ubiquitin- or ubiquitin-like interacting motif (UIM or ULIM) mimetics. In one embodiment, the modified ULM mimetic is a modified SUMO interaction motif (SIM) mimetic. According to the embodiments described herein, the compound inhibits ubiquitin- or ubiquitin-like protein (Ubl)-mediated protein-protein interactions and sensitizes cells to ionizing radiation. The modified UIM and ULIM mimetics may be conjugated to the AuNP such that each AuNP is conjugated to a plurality of modified UIM or ULIM mimetics. The modified ULIM mimetics may be conjugated to the AuNP via a thiol group.