Yuan Cheng

US Patent:

20230078200, Mar 16, 2023

Filed:

Dec 8, 2020

Appl. No.:

17/783232

Inventors:

- Thousand Oaks CA, US
Michael OLLMANN - San Carlos CA, US
Oliver HOMANN - Berkeley CA, US
Yuan CHENG - Newbury Park CA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

C12N 15/113
A61P 9/10

Abstract:

The present invention relates to RNAi constructs for reducing expression of the LPA gene, which encodes apolipoprotein(a), a component of lipoprotein(a) (Lp(a)) particles. Methods of using such RNAi constructs to treat or prevent cardiovascular disease, such as coronary artery disease, peripheral artery disease, stroke, and myocardial infarction, and to reduce serum Lp(a) levels are also described.

US Patent:

20210108212, Apr 15, 2021

Filed:

Oct 26, 2020

Appl. No.:

17/080771

Inventors:

- Thousand Oaks CA, US
Yang LI - Mountain View CA, US
Jun ZHANG - Foster City CA, US
Kaustav BISWAS - Agoura Hills CA, US
Oliver HOMANN - Berkeley CA, US
Leslie P. MIRANDA - Thousand Oaks CA, US
Justin K. MURRAY - Moorpark CA, US
Bin WU - Thousand Oaks CA, US
Oh Kyu YOON - Pacifica CA, US
John Gordon ALLEN - Newbury Park CA, US
Yuan CHENG - Newbury Park CA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

C12N 15/113
A61P 9/10
A61P 3/06
C07K 16/28

Abstract:

The present invention relates to RNAi constructs for reducing expression of the ASGR1 gene. Methods of using such RNAi constructs to treat or prevent cardiovascular disease, such as coronary artery disease and myocardial infarction, and to reduce serum non-HDL cholesterol levels are also described.

US Patent:

20210097119, Apr 1, 2021

Filed:

Sep 30, 2019

Appl. No.:

16/589049

Inventors:

- Redmond WA, US
Akihiro Maeda - Palo Alto CA, US
Yuta Labur - San Jose CA, US
Thao Bach - Mountain View CA, US
Yuan Cheng - San Jose CA, US
Alex Ting Yiao Wong - Sunnyvale CA, US
Maiko Takahashi Huang - San Jose CA, US
Guangyi Zhou - Redwood City CA, US
Saif Z. Ebrahim - Santa Clara CA, US

International Classification:

G06F 16/9535
G06F 16/93
H04L 29/08

Abstract:

Techniques for expanding an online connection network based on digital images of printed media are provided. In one technique, analysis data that is generated based on analyzing a digital image of a physical medium is received. The digital image is generated by a computing device of a scanning entity. One or more data items are identified within the analysis data. Based on the identified data item(s), it is determined whether a profile database includes a profile that includes a data item that matches one of the identified data item(s). In response to a positive determination, profile data about a scanned entity that is the subject of content on the physical medium and that is different than the scanning entity is retrieved from the profile. In response to identifying the profile, the profile data is transmitted over a computer network to be displayed on the computing device of the scanning entity.

US Patent:

20190309306, Oct 10, 2019

Filed:

Aug 25, 2017

Appl. No.:

16/328221

Inventors:

- Thousand Oaks CA, US
Yang LI - Mountain View CA, US
Jun ZHANG - Foster City CA, US
Kaustav BISWAS - Agoura Hills CA, US
Oliver HOMANN - Berkeley CA, US
Leslie P. MIRANDA - Thousand Oaks CA, US
Justin K. MURRAY - Moorpark CA, US
Bin WU - Thousand Oaks CA, US
Oh Kyu YOON - Pacifica CA, US
John Gordon ALLEN - Newbury Park CA, US
Yuan CHENG - Newbury Park CA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

C12N 15/113
A61P 3/06
A61P 9/10
C07K 16/28

Abstract:

The present invention relates to RNAi constructs for reducing expression of the ASGR1 gene. Methods of using such RNAi constructs to treat or prevent cardiovascular disease, such as coronary artery disease and myocardial infarction, and to reduce serum non-HDL cholesterol levels are also described.

US Patent:

20150231209, Aug 20, 2015

Filed:

Sep 13, 2013

Appl. No.:

14/426684

Inventors:

- Palo Alto CA, US
Yuan Cheng - Palo Alto CA, US
Masashi Deguchi - Kobe, JP
Kazuhiro Kawamura - Akita, JP

International Classification:

A61K 38/24
A61K 31/661
A61K 45/06
A61K 38/17
A61K 35/54
A61K 31/404
A61K 31/137

Abstract:

Methods are provided for stimulating ovarian follicles in a mammal through disruption of the Hippo signaling pathway.

US Patent:

20150081773, Mar 19, 2015

Filed:

Sep 2, 2014

Appl. No.:

14/474507

Inventors:

- Los Altos CA, US
Miles Spielberg - Sunnyvale CA, US
Yuan Cheng - Los Altos CA, US
Lance Co Ting Keh - Los Altos CA, US
Antoine Boulanger - San Francisco CA, US
Jonathan Berger - Los Altos CA, US
Komal Mangtani - Los Altos CA, US
Kevin Gao - San Francisco Bay CA, US
Remington Wong - San Francisco Bay CA, US
Naeim Semsarilar - San Carlos CA, US
Yingming Chen - Los Altos CA, US
Florian Jourda - San Francisco CA, US

International Classification:

G06F 17/30

US Classification:

709203, 707639

Abstract:

Embodiments in the present disclosure include systems and methods related to a high-availability architecture for a cloud-based concurrent-access collaboration platform. The disclosed technology relates to an active data center which includes multiple document server instances that handle user requests for concurrently accessing documents. Multiple document server instances are implemented on a single physical server. This architecture uses an instance assignment manager to assign documents to the document server instances, a primary repository to store backup snapshots of the documents, and a datastore to store all changes made to the documents. The disclosed technology also involves a backup data center that can be swapped with the active data center automatically.