Yun C Li

US Patent:

20080167288, Jul 10, 2008

Filed:

Feb 15, 2008

Appl. No.:

12/070310

Inventors:

Yun Long Li - Wilmington DE, US
Jincong Zhuo - Marcus Hook PA, US
David Burns - Philadelphia PA, US
Wanqing Yao - Kennett Square PA, US
Ravi Kumar Jalluri - Avondale PA, US

Assignee:

Lncyte Corporation - Wilmington DE

International Classification:

A61K 31/397
C07D 221/00
A61K 31/4523
C07D 295/00
A61K 31/5377
A61P 17/00
A61P 37/00
A61P 29/00
A61K 31/496
C07D 209/02
A61K 31/403
C07D 213/02
A61K 31/44
C07D 221/02
A61K 31/435
C07D 241/36
A61K 31/498
C07D 207/00
A61K 31/541
A61P 9/00
A61K 31/40
C07D 215/00
A61K 31/47
A61P 35/00
A61P 19/02
C07D 205/02

US Classification:

51421018, 546194, 514318, 544129, 5142355, 546187, 514316, 544360, 51425301, 546208, 514326, 548469, 514415, 546314, 514354, 546112, 514299, 544349, 514249, 548530, 514423, 546152, 514314, 544121, 5142358, 548953, 544 60, 5142278

Abstract:

The present invention provides compounds of the formula:its enantiomers, diastereomers, racemic mixtures thereof, prodrugs, crystalline forms, non-crystalline forms, amorphous forms thereof, solvates thereof, metabolites thereof, and pharmaceutically acceptable salts, wherein the ring A substituent groups are fully defined in the following disclosure. The compounds of formula are inhibitors of metalloproteases such as matrix metalloproteases and sheddases, and are useful in treating diseases such as rheumatoid arthritis, psoriasis, neoplastic diseases, allergies and all those diseases wherein inhibition of MMPs is desirable.

US Patent:

58836586, Mar 16, 1999

Filed:

Sep 29, 1997

Appl. No.:

8/939944

Inventors:

Paul C. Schubert - Marine-on-St. Croix MN
Yun Zhong Li - Woodbury MN

Assignee:

Imation Corp. - Oakdale MN

International Classification:

B41J 247
G02B 2608

US Classification:

347258

Abstract:

An optical scanner assembly for exposing an image on a photosensitive film. The photosensitive film is positioned on the internal surface of a drum. The optical scanner assembly includes a laser assembly for producing a laser beam representative of the image to be exposed on the photosensitive film, a scanner, and a long, flexible lens curved to the shape of the photosensitive film positioned on the internal surface of the drum, wherein the lens is positioned between the scanner and the film. The scanner operates to scan the laser beam through the lens across the surface of the photosensitive film in an image-wise pattern.

US Patent:

59910089, Nov 23, 1999

Filed:

Sep 30, 1997

Appl. No.:

8/941464

Inventors:

Yun Zhong Li - Woodbury MN
Douglas D. Jensen - Woodbury MN
Richard R. Lemberger - Columbus MN

Assignee:

Imation Corp. - St. Paul MN

International Classification:

G03B 2770
H04N 104

US Classification:

355 66

Abstract:

A method and system for compensating for scanner facet height error in a laser imaging application including a rotating polygon for directing a laser beam across a dimension of a photographic element. The present invention compensates for facet height error by measuring a scan interval for each facet of the rotating polygon and modifies the pixel clock for a subset of pixels of each scan line as a function of variations in scan intervals for the respective facets of the rotating polygon. Several advantages of the present invention have been illustrated including the low cost of such a compensation system and technique. Furthermore, the present invention is not limited in accuracy by the pixel clock as are conventional techniques. Furthermore, the modified pixels are evenly distributed over the entire length of the facet's corresponding scan line.

US Patent:

60575379, May 2, 2000

Filed:

Sep 29, 1997

Appl. No.:

8/939841

Inventors:

Paul C. Schubert - Marine-on-St. Croix MN
Yun Zhong Li - Woodbury MN

Assignee:

Eastman Kodak Company - Rochester NY

International Classification:

G01J 132

US Classification:

250205

Abstract:

An optical scanner feedback system. The feedback system provides a feedback signal representative of a laser beam focused along an optical path onto a scanning surface. The feedback system includes a cylinder lens having a longitudinal axis and a transverse axis, located along the optical path having an optical surface for shaping and focusing the laser beam in a first direction. A photodetector is provided having an active region sensitive to light. The laser beam includes a scanning portion which passes through the lens and a reflected portion which reflects off the lens. The reflected portion is reflected such that it is incident on the photodetector active region for providing an output signal representative of the laser beam.

US Patent:

59009632, May 4, 1999

Filed:

Sep 29, 1997

Appl. No.:

8/939900

Inventors:

Yun Zhong Li - Woodbury MN
Paul C. Schubert - Marine-on-St. Croix MN

Assignee:

Imation Corp. - Oakdale MN

International Classification:

G02B 2608

US Classification:

359205

Abstract:

An optical scanner assembly for exposing an image on a piece of photosensitive film positioned within an internal drum type exposure assembly. The optical scanner assembly is part of a laser imaging system suitable for use in a medical imaging system. The optical scanner assembly includes a laser mechanism for producing a laser beam representative of the image to be exposed on the photosensitive film. A first lens system is provided for shaping and focusing the laser beam in a first direction, including a long, flexible cylinder lens. A second lens system is provided for shaping and focusing the laser beam in a second direction, including a second cylinder lens oriented generally perpendicular to the long, flexible cylinder lens. A scanning and directing system is provided for directing the laser beam and scanning the laser beam across the photosensitive film in an image-wise pattern, including a rotating scanner mechanism, wherein the long, flexible cylinder lens is located between the rotating scanner mechanism and the photosensitive film.

US Patent:

59332689, Aug 3, 1999

Filed:

Sep 29, 1997

Appl. No.:

8/939308

Inventors:

Yun Zhong Li - Woodbury MN
Paul C. Schubert - Marine-on-St. Croix MN

Assignee:

Imation Corp. - Oakdale MN

International Classification:

G02B 2608

US Classification:

359207

Abstract:

An optical assembly for use in focusing a laser beam along an optical path onto a scanned surface. The optical assembly includes a first cylinder lens having a longitudinal axis and a transverse axis, located along the optical path for shaping and focusing the laser beam in a first direction, wherein the transverse axis is substantially perpendicular to the optical path. A second cylinder lens is provided having a longitudinal axis and a transverse axis, located along the optical path for shaping and focusing the laser beam in a second direction, wherein the transverse axis is substantially perpendicular to the optical path. The second cylinder lens longitudinal axis is not perpendicular to the optical path.

US Patent:

55961908, Jan 21, 1997

Filed:

Jun 2, 1995

Appl. No.:

8/459328

Inventors:

Yun Z. Li - Woodbury MN
Richard R. Lemberger - Forest Lake MN
Paul C. Schubert - Marine on St. Croix MN
Terrence H. Joyce - Lakeville MN
Jack K. Warren - Marine on St. Croix MN

Assignee:

Minnesota Mining and Manufacturing Company - St. Paul MN

International Classification:

H01J 314

US Classification:

250236

Abstract:

A light collection device for use in a film image digitizing apparatus comprises a housing having an elongated aperture extending along a light beam scan line. The aperture receives light transmitted through a sheet of film from a light source. A diffusing member, disposed within the aperture and extending along the scan line, optically diffuses the light received by the aperture. The housing may include one or more reflective interior surfaces. A linear array of photodiodes, disposed within the housing and extending along the scan line, detects the light diffused by the diffusing member. Each of the photodiodes generates an analog signal representing an intensity of the detected light for each of a plurality of pixels. A summing circuit, coupled to each of the photodiodes, sums the analog signals generated by the photodiodes for each of the pixels to produce an output analog signal representing an overall intensity of the light transmitted through the sheet of film for each of the pixels.

US Patent:

60644168, May 16, 2000

Filed:

Sep 29, 1997

Appl. No.:

8/939420

Inventors:

Jay A. Esch - River Falls WI
Timothy S. Vraa - Apple Valley MN
Yun Zhong Li - Woodbury MN
Paul C. Schubert - Marine on St. Croix MN
James E. Steffen - Woodbury MN

Assignee:

Eastman Kodak Company - Rochester NY

International Classification:

B41J 25304

US Classification:

347225

Abstract:

A linear translation system for use in a laser imaging system. The linear translation system includes a base member including a pair of longitudinally extending guide rails positioned parallel to each other. A carriage mechanism is carried by the base member, wherein the carriage mechanism is slidably coupled to the guide rails using a three position kinematic design. A rotary to linear motion mechanism is coupled to the carriage mechanism which slidably moves the carriage mechanism along the guide rails. A laser imaging assembly is coupled to the carriage mechanism.