Yung Hing Cheng

US Patent:

20080292687, Nov 27, 2008

Filed:

Jun 5, 2006

Appl. No.:

11/921194

Inventors:

Yung Chi Cheng - Woodbridge CT, US

Assignee:

Yale University - New haven CT

International Classification:

A61K 9/127
A61K 31/7072
C07H 7/06
A61P 35/00
A61K 38/20

US Classification:

424450, 514 50, 536 292, 424 852

Abstract:

The present invention relates to the use of the compound according to formula (I), below for the treatment of tumors, cancer and hyperproliferative diseases, among other conditions or disease states: Where X is H or F; Rand Rare independently H, an acyl group, a C-Calkyl or ether group, a phosphate, diphosphate, triphosphate or a phosphodiester group, a (A) or (B) group; Where Nu is a radical of a biologically active compound such as an anticancer, antiviral or antihyperproliferative compound such that an amino group or hydroxyl group from said biologically active agent forms a phosphate, phosphoramidate, carbonate or urethane group with the adjacent moiety; each Ris independently H, or a C-Calkyl or ether group, preferably a C-Calkyl group; k is 0-12, preferably, 0-2; and pharmaceutically acceptable salts thereof.