Zhen Cheng

US Patent:

8343458, Jan 1, 2013

Filed:

Apr 3, 2009

Appl. No.:

12/418116

Inventors:

Matthew S. Bogyo - Redwood City CA, US
Galia Blum - Jerusalem, IL
Alicia Berger - San Francisco CA, US
Zhen Cheng - Stanford CA, US
Sanjiv S. Gambhir - Stanford CA, US

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

International Classification:

A61K 51/00
A61M 36/14

US Classification:

424 169, 424 111, 424 165, 424 91, 424 93, 424 934, 424 94

Abstract:

Activity-based probes, which are specific for certain active cysteine proteases (caspase, cathepsin and legumain) and carry radioactive labels, are disclosed. The present probes comprise an acyloxymethyketone (AOMK) “warhead” that binds only to active enzyme. The probes further comprise peptide-like structure that targets the probe to a specific cysteine protease or protease family, and a radiolabel on the probe, which is bound to the targeted enzyme. It has been found that the present probes are stable in vivo and give specific target images distinguishable over background. The preferred probes are labeled with a positron-emitting agent such as Cu, I (SPECT) and Tc (PET). The probes show in vivo half-life and stability well suited for imaging.

US Patent:

20060280687, Dec 14, 2006

Filed:

Mar 17, 2006

Appl. No.:

11/378988

Inventors:

Zhen Cheng - Mountain View CA, US
Sanjiv Gambhir - Portola Valley CA, US

International Classification:

A61K 49/00
C07D 403/02
C07H 5/06

US Classification:

424009600, 536018700, 548427000, 536055300, 536053000

Abstract:

Briefly described, embodiments of this disclosure include cyanine/glucose compounds, methods of use, methods of imaging tissue, methods of imaging precancerous tissue, cancer, and tumors, methods of treating precancerous tissue, cancer, and tumors, methods of diagnosing precancerous tissue, cancer and tumors, methods of monitoring the progress of precancerous tissue, cancer and tumors, and the like.

US Patent:

20070092442, Apr 26, 2007

Filed:

Oct 23, 2006

Appl. No.:

11/584936

Inventors:

Sanjiv Gambhir - Portolla Valley CA, US
Zhen Cheng - Mountain View CA, US

International Classification:

A61K 51/00

US Classification:

424001110

Abstract:

The present disclosure provides mitochondrial imaging probes, particularly imaging probes capable of imaging changes in mitochondrial membrane potential and conditions associated with mitochondrial dysfunction.

US Patent:

20070092907, Apr 26, 2007

Filed:

Oct 20, 2006

Appl. No.:

11/584191

Inventors:

Sanjiv Gambhir - Portolla Valley CA, US
Zhen Cheng - Mountain View CA, US

International Classification:

C40B 30/06
G01N 33/53

US Classification:

435006000, 435007100, 436086000

Abstract:

Briefly described, embodiments of this disclosure include methods for identifying compound probe candidates, methods of screening compound probe candidates, methods of preparing molecular imaging probes, high throughput methods for identifying molecular imaging probes in a library, and the like.

US Patent:

20090004105, Jan 1, 2009

Filed:

Jun 25, 2008

Appl. No.:

12/215136

Inventors:

Zhen Cheng - Mountain View CA, US
Sanjiv S. Gambhir - Portolla Valley CA, US

International Classification:

A61K 51/00
G01N 1/30

US Classification:

424 169, 424 111, 435 4052

Abstract:

Embodiments of the present disclosure provide for: methods for imaging MMP-2 positive tissue; methods of diagnosing the presence of one or more of MMP-2 positive precancerous cells, MMP-2 positive cancerous cells, MMP-2 positive tumor cells, and MMP-2 positive diseases in a tissue; method of monitoring the progress of one or more of MMP-2 positive precancerous cells, MMP-2 positive cancerous cells, MMP-2 positive tumor cells, and MMP-2 positive diseases in a tissue; pharmaceutical compositions for imaging one or more of MMP-2 positive precancerous cells, MMP-2 positive cancerous cells, MMP-2 positive tumor cells, and MMP-2 positive diseases; compositions; kits; and the like.

US Patent:

20090257952, Oct 15, 2009

Filed:

Apr 3, 2009

Appl. No.:

12/418376

Inventors:

Jennifer R. COCHRAN - Stanford CA, US
Richard KIMURA - Stanford CA, US
Aron M. LEVIN - Redwood City CA, US
Adam SILVERMAN - Menlo Park CA, US
Sanjiv S. GAMBHIR - Portola Valley CA, US
Zhen CHENG - Mountain View CA, US
Jennifer LAHTI - Belmont CA, US

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

International Classification:

A61K 38/16
C07K 2/00
C12N 15/63
A61K 49/00
C07H 21/00
C12N 5/10
A61K 51/08

US Classification:

424 169, 514 12, 530324, 4353201, 424 91, 536 231, 435325

Abstract:

Engineered peptides that bind with high affinity (low equilibrium dissociation constant (Kd)) to the cell surface receptors of fibronectin (αβ) or vitronectin (αβand αβintegrins) are disclosed. These peptides are based on a molecular scaffold into which a subsequence containing the RGD integrin-binding motif has been inserted. The subsequence (RGD mimic) comprises about 9-13 amino acids, and the RGD contained within the subsequence can be flanked by a variety of amino acids, the sequence of which was determined by sequential rounds of selection (in vitro evolution). The molecular scaffold is preferably based on a knottin, e.g., EETI (Trypsin inhibitor 2 (Trypsin inhibitor II) (EETI-II) [(Jumping cucumber)], AgRP (Agouti-related protein), and Agatoxin IVB, which peptides have a rigidly defined three-dimensional conformation. It is demonstrated that EETI tolerates mutations in other loops and that the present peptides may be used as imaging agents.

US Patent:

20120107240, May 3, 2012

Filed:

Nov 3, 2011

Appl. No.:

13/373072

Inventors:

Shuanglong Liu - Mountain View CA, US
Hongguang Liu - Palo Alto CA, US
Zhen Cheng - Mountain View CA, US

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

International Classification:

A61K 51/00
C07D 211/78
C12Q 1/02

US Classification:

424 189, 435 29, 546328

Abstract:

Embodiments of the present disclosure provide for labeled probes such as a 3-F-fluoropicolinamide probe, methods of making labeled probes, pharmaceutical compositions including labeled probes, methods of using labeled probes, methods of diagnosing, localizing, monitoring, and/or assessing melanin related diseases, cancers, tumors, precancerous cells, and related biological events (e.g., malignant melanoma), using labeled probes, kits for diagnosing, localizing, monitoring, and/or assessing melanin related diseases, cancers, tumors, precancerous cells, and related biological events, using labeled probes, and the like.

US Patent:

20120220870, Aug 30, 2012

Filed:

Feb 28, 2012

Appl. No.:

13/406891

Inventors:

Sanjiv S. Gambhir - Portola Valley CA, US
Zhen Cheng - Mountain View CA, US
Hongguang Liu - Palo Alto CA, US

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

International Classification:

A61B 6/00
G01J 1/42
G01T 1/20
A61K 51/00
G01J 5/10
B82Y 5/00
B82Y 30/00

US Classification:

600431, 424 111, 250200, 2503412, 250362, 977774, 977904

Abstract:

Embodiments of the present disclosure provide for radionuclide probes, methods of using the radionuclide probes, methods of detecting an optical signal from radionuclides, methods of detecting an optical signal from a quantum dot(s) that receives optical energy from a radionuclide(s), system for analyzing optical energy emitted by a radionuclide(s), system for imaging a target within a living subject or a sample, methods of imaging a disease or condition, and the like.