Zhen L Li

US Patent:

7879875, Feb 1, 2011

Filed:

Aug 8, 2006

Appl. No.:

11/990050

Inventors:

Meng-Hsin Chen - Westfield NJ, US
James B. Doherty - Montvale NJ, US
Robert Tynebor - Hatfield PA, US
Swaminathan R. Natarajan - Scotch Plains NJ, US
Zhen Li - Scotch Plains NJ, US
Soumya P. Sahoo - Old Bridge NJ, US

Assignee:

Merk Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 31/4375
C07D 455/02

US Classification:

514306, 546138

Abstract:

Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: (I) are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.

US Patent:

20110183959, Jul 28, 2011

Filed:

Jan 25, 2011

Appl. No.:

13/013222

Inventors:

Meng-Hsin Chen - Westfield NJ, US
James B. Doherty - Montvale NJ, US
Robert Tynebor - Hatfield PA, US
Swaminathan R. Natarajan - Scotch Plains NJ, US
Zhen Li - Scotch Plains NJ, US
Soumya P. Sahoo - Old Bridge NJ, US

International Classification:

A61K 31/506
A61K 31/4375
C07D 455/02
A61P 25/04

US Classification:

51421018, 514306, 514256, 546138

Abstract:

Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof:are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.

US Patent:

62011588, Mar 13, 2001

Filed:

May 27, 1999

Appl. No.:

9/321008

Inventors:

Zhen Li - Scotch Plains NJ
Ann Decamp - Scotch Plains NJ
Veena Upadhyay - Westfield NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07C 3328

US Classification:

568813

Abstract:

The present invention relates to a process for making propargylic alcohols by zinc-mediated catalytic, asymmetric addition of acetylenes to aldehydes. The compounds are represented by formula I: ##STR1##.