Anna Y Wu

US Patent:

7939649, May 10, 2011

Filed:

Sep 6, 2006

Appl. No.:

11/995586

Inventors:

Sanjiv S. Gambhir - Portolla Valley CA, US
Andreas M. Loening - Stanford CA, US
Anna M. Wu - Sherman Oaks CA, US

Assignee:

Stanford University - Palo Alto CA
Regents of University of California - Oakland CA

International Classification:

C07H 21/04
C12N 5/00

US Classification:

536 232, 435325

Abstract:

Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides or fragments thereof encoded by the polynucleotides, constructs including the polynucleotide, expression cassettes, cells, methods of producing the polynucleotides and polypeptides, antibodies, transgenic cells and/or animals, kits, and the like.

US Patent:

8173791, May 8, 2012

Filed:

Mar 24, 2011

Appl. No.:

13/070665

Inventors:

Sanjiv S. Gambhir - Portollo Valley CA, US
Andreas M. Loening - Stanford CA, US
Anna M. Wu - Sherman Oaks CA, US

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
The Regents of teh University of California - Oakland CA

International Classification:

C07H 21/04
C12N 15/00
C12N 9/02

US Classification:

536 232, 435189, 4353201

Abstract:

Briefly described, embodiments of this disclosure include polynucleotides that encode mutant luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides or fragments thereof encoded by the polynucleotides, constructs including the polynucleotide, expression cassettes, cells, methods of producing the polynucleotides and polypeptides, antibodies, transgenic cells and/or animals, kits, and the like.

US Patent:

8258277, Sep 4, 2012

Filed:

Mar 22, 2012

Appl. No.:

13/426790

Inventors:

Sanjiv S. Gambhir - Portollo Valley CA, US
Andreas M. Loening - Stanford CA, US
Anna M. Wu - Sherman Oaks CA, US

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
The Regents of the University of California - Oakland CA

International Classification:

C07H 21/04
C12N 5/00

US Classification:

536 232, 435325

Abstract:

Briefly described, embodiments of this disclosure include polynucleotides that encode mutant luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides or fragments thereof encoded by the polynucleotides, constructs including the polynucleotide, expression cassettes, cells, methods of producing the polynucleotides and polypeptides, antibodies, transgenic cells and/or animals, kits, and the like.

US Patent:

8378086, Feb 19, 2013

Filed:

Jul 31, 2012

Appl. No.:

13/562881

Inventors:

Sanjiv S. Gambhir - Portollo Valley CA, US
Andreas M. Loening - Stanford CA, US
Anna M. Wu - Sherman Oaks CA, US

International Classification:

C07H 21/04
C12N 5/00

US Classification:

536 232, 435325

Abstract:

Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides or fragments thereof encoded by the polynucleotides, constructs including the polynucleotide, expression cassettes, cells, methods of producing the polynucleotides and polypeptides, antibodies, transgenic cells and/or animals, kits, and the like.