Jing Zhang

US Patent:

20070087364, Apr 19, 2007

Filed:

Sep 27, 2006

Appl. No.:

11/527999

Inventors:

Joe Shuga - Cambridge RI, US
Linda Griffith - Cambridge MA, US
Harvey Lodish - Brookline MA, US
Leona Samson - Newton MA, US
Dharini Shah - Cambridge MA, US
Jing Zhang - Newton MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

C12Q 1/68

US Classification:

435006000

Abstract:

The present invention is directed to novel assays to measure the genotoxic effects of compounds on erythroid cells in vitro.

US Patent:

20130310384, Nov 21, 2013

Filed:

Oct 4, 2011

Appl. No.:

13/877419

Inventors:

Corinne E. Augelli-Szafran - Newton MA, US
Dai Lu - Boston MA, US
Hanxun Wei - West Roxbury MA, US
Jing Zhang - Lexington MA, US
Michael S. Wolfe - Newton MA, US
Dennis J. Selkoe - Jamaica Plain MA, US

Assignee:

THE BRIGHAM AND WOMEN'S HOSPITAL, INC. - Boston MA

International Classification:

C07C 311/16
C07C 311/18
C07D 295/32
C07D 263/14
C07D 213/42
C07C 311/19
C07D 271/06

US Classification:

5142388, 564 92, 514604, 548131, 514364, 548238, 514374, 546338, 514357, 544159

Abstract:

This invention relates generally to the discovery of sulfonamide-containing compounds that are inhibitors of γ-secretase.

US Patent:

20200165251, May 28, 2020

Filed:

May 8, 2018

Appl. No.:

16/611065

Inventors:

- Waltham MA, US
Thomas Francois Durand-Reville - Belmont MA, US
Satenig Guler - Waltham MA, US
Jan Romero - Arlington MA, US
Mark Sylvester - Waltham MA, US
Ruben Tommasi - Stow MA, US
Camilo Velez-Vega - Waltham MA, US
Xiaoyun Wu - Westborough MA, US
Jing Zhang - Sudbury MA, US

International Classification:

C07D 471/18
A61P 31/04

Abstract:

Provided herein are antibacterial compounds represented by Formula I, or a pharmaceutically acceptable salt thereof, wherein X, Y, R, R, and Rare as defined herein. Also provided are pharmaceutical compositions comprising the compounds of Formula I.

US Patent:

20190321185, Oct 24, 2019

Filed:

Mar 20, 2019

Appl. No.:

16/359178

Inventors:

- Cambridge MA, US
Kai Xu - Somerville MA, US
Jing Zhang - Somerville MA, US

International Classification:

A61F 2/36

Abstract:

A method of manufacturing a femoral stem for a hip implant includes forming a femoral neck extending from a proximal end of the femoral stem towards a distal end of the femoral stem, forming an upper section connected to and extending from the femoral neck towards the distal end of the femoral stem, and forming a lower section connected to and extending from the upper section to the distal end of the femoral stem. Further, a method for designing a femoral stem for a hip implant includes generating a customized femoral stem model to match an information of a patient, generating at least one proximal-distal solid rib in the upper section, calculating density and stress distributions for an open lattice and for a closed lattice, and selecting a unit cell type and a pore size for the open lattice and the closed lattice to match a density and/or a stiffness of the patient's femur.

US Patent:

20190202832, Jul 4, 2019

Filed:

Sep 15, 2017

Appl. No.:

16/333900

Inventors:

- Altrincham, Cheshire, GB
Janelle Comita-Prevoir - Northborough MA, US
Thomas Francois Durand-Reville - Belmont MA, US
Lise Gauthier - Waltham MA, US
Bill Moss - Prestbury, Cheshire, GB
John O'Donnell - Mattapoisett MA, US
Jan Romero - Arlington MA, US
Ruben Tommasi - Stow MA, US
Jeroen Cunera Verheijen - Westborough MA, US
Frank Wu - Shrewsbury MA, US
Xiaoyun Wu - Westborough MA, US
Jing Zhang - Sudbury MA, US

Assignee:

Entasis Therapeutics Limited - Altrincham, Cheshire

International Classification:

C07D 471/08
C07D 211/78
A61K 31/439
A61K 31/546
A61P 31/04

Abstract:

The present invention is directed to compounds which are beta-lactamase inhibitors. The compounds and their pharmaceutically acceptable salts are useful in combination with beta-lactam antibiotics, for the treatment of bacterial infections, including infections caused by drug resistant organisms, including multi-drug resistant organisms. The present invention includes compounds according to Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of R, R, R, R, Rand Rare described herein.

US Patent:

20170216295, Aug 3, 2017

Filed:

Jul 27, 2015

Appl. No.:

15/501103

Inventors:

Blaise Lippa - Acton MA, US
Xin Zhang - Belmont MA, US
Jon Christian Baber - Somerville MA, US
Jan Antionette C. Romero - Somerville MA, US
Jing Zhang - Lexington MA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 31/519
C07D 487/04

Abstract:

Provided herein are compounds that inhibit CCR9 receptor function. Also provided herein are methods of treating inflammatory disease in a subject, comprising administering to the subject a compound of the invention. Accordingly, in one aspect, provided herein is a compound of Formula (1) or a pharmaceutically acceptable salt thereof. In another aspect, provided herein is a pharmaceutical composition, comprising a compound of Formula (1), and a pharmaceutically acceptable carrier.

US Patent:

20170014547, Jan 19, 2017

Filed:

Feb 26, 2015

Appl. No.:

15/121734

Inventors:

- Boston MA, US
Jing Zhang - Worcester MA, US

International Classification:

A61L 27/18
A61L 27/54
A61L 27/56
C08G 63/82
A61L 31/14
A61L 31/16
C08G 63/664
A61L 27/58
A61L 31/10

Abstract:

The invention provides a novel approach to controlled delivery of biomolecules (e.g., lipids and proteins) by employing novel amphiphilic polymers that are effective delivery vehicles. These unique amphiphilic polymers may be employed as controlled delivery vehicles or tissue engineering scaffolds wherein the delivery of lipophilic or amphiphilic bioactive molecules can be achieved. An amphiphilic biodegradable polymer platform is disclosed herein for the stable encapsulation and sustained release of biomolecules, such as S1P.

US Patent:

20140243374, Aug 28, 2014

Filed:

Oct 4, 2012

Appl. No.:

14/349206

Inventors:

- Boston MA, US
Dai Lu - Boston MA, US
HanXun Wei - West Roxbury MA, US
Jing Zhang - Lexington MA, US
Michael S. Wolfe - West Newton MA, US
Dennis J. Selkoe - Jamaica Plain MA, US

International Classification:

C07C 311/20
C07D 213/71
C07C 311/19
C07D 309/14
C07D 309/06
C07D 405/12
C07D 207/09

US Classification:

514336, 514347, 514428, 514459, 514524, 514539, 514604, 5462821, 546293, 548567, 549424, 549426, 558413, 560 12, 564 92

Abstract:

This invention relates generally to the discovery of sulfonamide-containing compounds that are inhibitors of γ-secretase.