Joshua D Thomas

US Patent:

20120321583, Dec 20, 2012

Filed:

Jun 11, 2012

Appl. No.:

13/493899

Inventors:

Aleksandr Yurkovetskiy - Littleton MA, US
Mao Yin - Needham MA, US
Timothy B. Lowinger - Carlisle MA, US
Joshua D. Thomas - Natick MA, US
Charles E. Hammond - Billerica MA, US
Cheri A. Stevenson - Haverhill MA, US
Natalya D. Bodyak - Brookline MA, US
Patrick R. Conlon - Wakefield MA, US
Dmitry R. Gumerov - Waltham MA, US

Assignee:

Mersana Therapeutics, Inc. - Cambridge MA

International Classification:

C08G 65/333
C08G 65/332
A61P 35/00
A61P 35/02
A61K 47/48
C07K 5/103

US Classification:

424 7817, 530330, 525413, 525411, 525 541

Abstract:

A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L-D, the protein based recognition-molecule being connected to the polymeric carrier by L. Each occurrence of D is independently a therapeutic agent having a molecular weight ≦5 kDa. Land Lare linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.

US Patent:

20130101546, Apr 25, 2013

Filed:

Dec 10, 2012

Appl. No.:

13/710355

Inventors:

Mao Yin - Needham MA, US
Timothy B. Lowinger - Carlisle MA, US
Joshua D. Thomas - Natick MA, US
Charles E. Hammond - Billerica MA, US
Cheri A. Stevenson - Haverhill MA, US
Natalya D. Bodyak - Brookline MA, US
Patrick R. Conlon - Wakefield MA, US
Dmitry R. Gumerov - Waltham MA, US

Assignee:

MERSANA THERAPEUTICS, INC. - Cambridge MA

International Classification:

A61K 47/48
C08G 65/332
C08G 65/334
C08G 65/333

US Classification:

424 7817, 525411, 525 541

Abstract:

A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L-D, the protein based recognition-molecule being connected to the polymeric carrier by L. Each occurrence of D is independently a therapeutic agent having a molecular weight≦5 kDa. Land Lare linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.

US Patent:

20130309192, Nov 21, 2013

Filed:

Jul 17, 2013

Appl. No.:

13/944561

Inventors:

Mao Yin - Needham MA, US
Timothy B. Lowinger - Carlisle MA, US
Joshua D. Thomas - Natick MA, US
Charles E. Hammond - Billerica MA, US
Cheri A. Stevenson - Haverhill MA, US
Natalya D. Bodyak - Brookline MA, US
Patrick R. Conlon - Wakefield MA, US
Dmitry R. Gumerov - Waltham MA, US

Assignee:

MERSANA THERAPEUTICS, INC. - Cambridge MA

International Classification:

A61K 47/48
C07K 7/02

US Classification:

424 7817, 530330, 525 541, 514 218

Abstract:

Auristatin compounds and conjugates thereof are provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L-D, the protein based recognition-molecule being connected to the polymeric carrier by L. Each occurrence of D is independently an Auristatin compound. Land Lare linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.

US Patent:

20220378749, Dec 1, 2022

Filed:

Apr 2, 2021

Appl. No.:

17/221341

Inventors:

- Cambridge MA, US
Keith W. BENTLEY - Everett MA, US
Raghida A. BUKHALID - Medford MA, US
Marc I. DAMELIN - Needham MA, US
Eugene W. KELLEHER - Wellesley MA, US
Timothy B. LOWINGER - Carlisle MA, US
Joshua D. THOMAS - Natick MA, US
Dorin TOADER - Cambridge MA, US
Ling XU - Brookline MA, US
Liping YANG - Arlington MA, US

International Classification:

A61K 31/4184
A61K 47/54
A61K 47/65
A61K 47/60
A61K 47/55
A61K 45/06
A61K 47/68
A61P 35/00
A61K 31/422
A61K 31/437
A61K 31/428

Abstract:

The present disclosure provides scaffolds and antibody-drug conjugates (ADCs) comprising a stimulator of interferon genes (STING). The present disclosure also provides uses of the ADCs in treatment, e.g., treatment of cancer.

US Patent:

20230074558, Mar 9, 2023

Filed:

Dec 4, 2020

Appl. No.:

17/782796

Inventors:

- Cambridge MA, US
Keith W. BENTLEY - Everett MA, US
Ha Thi DO - Dallas TX, US
Brian D. JONES - Brookline MA, US
Nabeelah I. KAUSER - Watertown MA, US
Eugene W. KELLEHER - Wellesley MA, US
Soumya S. RAY - Quincy MA, US
Joshua D. THOMAS - Natick MA, US
Dorin TOADER - Cambridge MA, US
Liping YANG - Arlington MA, US

International Classification:

A61K 47/54

Abstract:

The present disclosure relates to dimeric STING agonists of Formulae (I), (II), (III), (IV), (V), and (VI), and pharmaceutically acceptable salts thereof. The present disclosure also relates to methods of preparing the compounds and methods of using the compounds.

US Patent:

20210106690, Apr 15, 2021

Filed:

Jan 23, 2020

Appl. No.:

16/750246

Inventors:

- Cambridge MA, US
Mao YIN - Needham MA, US
Timothy B. LOWINGER - Carlisle MA, US
Joshua D. THOMAS - Natick MA, US
Charles E. HAMMOND - Billerica MA, US
Cheri A. STEVENSON - Haverhill MA, US
Natalya D. BODYAK - Boston MA, US
Patrick R. CONLON - Wakefield MA, US
Dmitry R. GUMEROV - Waltham MA, US

International Classification:

A61K 47/58
C08G 65/334
C08G 6/00
C08L 71/00
A61K 47/68
A61K 47/60
A61K 47/59
C08G 65/333
C08G 65/332
A61K 47/64

Abstract:

A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L-D, the protein based recognition-molecule being connected to the polymeric carrier by L. Each occurrence of D is independently a therapeutic agent having a molecular weight ≤5 kDa. Land Lare linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.

US Patent:

20210032269, Feb 4, 2021

Filed:

Jul 31, 2020

Appl. No.:

16/944646

Inventors:

- Cambridge MA, US
Keith W. BENTLEY - Everett MA, US
Brian D. JONES - Allston MA, US
Eugene W. KELLEHER - Wellesley MA, US
Soumya S. RAY - Quincy MA, US
Joshua D. THOMAS - Natick MA, US
Dorin TOADER - Cambridge MA, US

International Classification:

C07D 519/00
C07D 413/14
C07D 417/14
C07D 403/14
C07D 471/04
C07D 487/04
C07D 513/04

Abstract:

The present disclosure relates to STING (Stimulator of Interferon Genes) agonist compounds, methods of making the compounds and their methods of use.

US Patent:

20190070194, Mar 7, 2019

Filed:

Nov 6, 2018

Appl. No.:

16/181867

Inventors:

- Cambridge MA, US
Joshua D. THOMAS - Natick MA, US
Aleksandr V. YURKOVETSKIY - Littleton MA, US
Patrick R. CONLON - Wakefield MA, US
Bingfan DU - Cambridge MA, US
Eugene W. KELLEHER - Wellesley MA, US
Timothy B. LOWINGER - Carlisle MA, US
Shuyi TANG - Shanghai, CN

International Classification:

A61K 31/55
C07D 403/14
C07D 487/04

Abstract:

The present disclosure relates generally to derivatives of pyrrolobenzodiazepines and antibody-drug conjugates thereof and to methods of using these conjugates as therapeutics and/or diagnostics.