Small molecular weight molecules are provided including, but not limited to, peptides, peptide analogs and peptide mimetics that stabilize and prevent the aggregation of abnormally folded and compromised proteins. Methods for treatment of disease are provided utilizing the peptides, peptide analogs or peptide mimetics, or utilizing nucleic acids encoding the peptides.
Compositions And Methods For Treatment Of Cancer Or Neurodegenerative Disease With Peptide Based Microtubule Stabilizers Or Inhibitors
Small molecular weight molecules are provided including, but not limited to, peptides, peptide analogs and peptide mimetics that can interact with microtubules to promote their assembly or prevent their disassembly and can interrupt mitosis, prevent cell division, and trigger apoptosis. methods for the prevention or treatment of neoplastic disease in a mammalian subject are provided utilizing peptides, peptide analogs and peptide mimetics, or utilizing nucleic acids encoding the peptides.
Compositions And Methods For Antibodies Targeting Factor P
- Basel, CH Ute Jaeger - Muenchen, DE Yong-In Kim - Westborough MA, US Christian Carsten Silvester Kunz - Muenchen, DE Igor Splawski - Winchester MA, US Michael Roguska - Ashland MA, US Joy Ghosh - Brookline MA, US Barbara Brannetti - Basel, CH
The present invention relates to antibodies or antigen binding fragments thereof that bind to complement Factor P and used thereof as well as combinations of anti-Factor P antibodies with antibodies or antigen binding fragments thereof that bind to complement component 5 (C5).
Compositions And Methods For Treatment Of Protein Misfolding And Protein Aggregation Diseases
Small molecular weight molecules are provided including, but not limited to, peptides, peptide analogs and peptide mimetics that stabilize and prevent the aggregation of abnormally folded and compromised proteins. Methods for treatment of disease are provided utilizing the peptides, peptide analogs or peptide mimetics, or utilizing nucleic acids encoding the peptides.
Anti-Betacellulin Antibodies, Fragments Thereof, And Multi-Specific Binding Molecules
- Basel, CH Ana Maria CARRION - Wellesley MA, US James Edgar CHASTAIN - Acton MA, US Kirk Lee CLARK - Stow MA, US Joy Gispati GHOSH - Boston MA, US Shawn Michael HANKS - Sudbury MA, US Nicole HAUBST - Munchen, DE Ganesh Rajan IYER - South Grafton MA, US Nina MOKER - Koln, DE Andrew Anh NGUYEN - Brookline MA, US Stephen Hendrick POOR - Winthrop MA, US Yubin QIU - Newton MA, US Nalini Velamur RANGASWAMY - Wakefield MA, US Michael STEFANIDAKIS - Brookline MA, US Engin TOKSOZ - Munchen, DE Michael Zbigniew TWAROG - Cambridge MA, US
International Classification:
C07K 16/22 A61P 27/02 C07K 16/46
Abstract:
The present disclosure provides anti-BTC antibodies, methods of producing said antibodies, pharmaceutical compositions comprising said antibodies, and methods of using said antibodies. The present disclosure also provides multi-specific binding molecules, e.g., bispecific antibodies, comprising a BTC binding moiety and an anti-VEGF binding moiety.
Anti-Betacellulin Antibodies, Fragments Thereof, And Multi-Specific Binding Molecules
- Basel, CH Ana Maria CARRION - Wellesley MA, US James Edgar CHASTAIN - Acton MA, US Kirk Lee CLARK - Stow MA, US Joy Gispati GHOSH - Boston MA, US Shawn Michael HANKS - Sudbury MA, US Nicole HAUBST - , US Ganesh Rajan IYER - South Grafton MA, US Nina MOKER - , US Andrew Anh NGUYEN - Brookline MA, US Stephen Hendrick POOR - Winthrop MA, US Yubin QIU - Newton MA, US Nalini Velamur RANGASWAMY - Wakefield MA, US Michael STEFANIDAKIS - Brookline MA, US Engin TOKSOZ - , US Michael Zbigniew TWAROG - Cambridge MA, US
International Classification:
C07K 16/22 A61P 27/02 C07K 16/46
Abstract:
The present disclosure provides anti-BTC antibodies, methods of producing said antibodies, pharmaceutical compositions comprising said antibodies, and methods of using said antibodies. The present disclosure also provides multi-specific binding molecules, e.g., bispecific antibodies, comprising a BTC binding moiety and an anti-VEGF binding moiety.
Compositions And Methods For Antibodies Targeting Factor P
- Basel, CH Ute JAEGER - Muenchen, DE Yong-In KIM - Seongnam-si, KR Christian Carsten Silvester KUNZ - Muenchen, DE Igor SPLAWSKI - Winchester MA, US Michael ROGUSKA - Old Orchard Beach ME, US Joy GHOSH - Boston MA, US Barbara BRANNETTI - Cambridge MA, US Michael STEFANIDAKIS - Brookline MA, US Sha-Mei LIAO - Lexington MA, US
Assignee:
Novartis AG - Basel
International Classification:
C07K 16/18 C07K 16/24 G01N 33/68 A61K 39/395
Abstract:
The present invention relates to antibodies or antigen binding fragments thereof that bind to complement Factor P and used thereof as well as combinations of anti-Factor P antibodies with antibodies or antigen binding fragments thereof that bind to complement component 5 (C5).
Joy GHOSH - Boston MA, US Yunsheng HE - Waltham MA, US
International Classification:
C12Q 1/6883 C07K 16/22 A61P 27/02
Abstract:
The invention features methods of identifying patients as being likely to respond to anti-VEGF therapy. Furthermore, in those patients identified as failing to include one or more of the above ophthalmic response markers, the invention features treatment with an EPO antagonist (e.g., alone, or in combination with a VEGF antagonist).
Bain Capital
Associate
Biogen May 2016 - Jan 2017
Senior Manager, Corporate Development, M and A, and Strategy
Novartis Institutes For Biomedical Research (Nibr) Sep 2013 - May 2016
Investigator Iii
Novartis Sep 2013 - May 2016
Team Member  Business Development and Licensing Team
Novartis Institutes For Biomedical Research (Nibr) May 2009 - Sep 2013
Investigator Ii
Education:
Harvard Medical School May 2009
Cold Spring Harbor Laboratory 2007 - 2007
University of Washington 2006
University of Washington - Michael G. Foster School of Business 2004 - 2006
University of Washington - School of Medicine 2000 - 2006
Doctorates, Doctor of Philosophy, Biology, Neuroscience
The Benaroya Research Institute 2005
University of Washington 2004
The University of Texas at Austin 1998 - 2000
Bachelors, Bachelor of Science, Biochemistry
Skills:
Drug Discovery Drug Development Molecular Biology Life Sciences Biochemistry Assay Development Biotechnology Protein Chemistry Cell Biology Neuroscience Business Development Pharmaceutical Industry Immunology Antibodies Lifesciences Clinical Trials Business Strategy Cross Functional Team Leadership Commercialization Monoclonal Antibodies Pharmacokinetics Technology Transfer Due Diligence Oncology Strategic Leadership Translational Research Financial Modeling Drug Design Translational Medicine Entrepreneurship Neurodegeneration Program Management Ophthalmology Protein Engineering Business Valuation Diabetic Retinopathy Alzheimer's Disease Medicine Protein Purification Parkinson's Diabetes Ind Biologics Target Identification Drug Delivery
Drug Discovery Drug Design Monoclonal Antibodies Protein Engineering Translational Research Translational Medicine Immunology Ophthalmology Macular Degeneration Commercialization Entrepreneurship Diabetic Retinopathy Alzheimer's disease Neurodegeneration Medicine Antibodies Lifesciences Biophysics Drug Development Neuroscience Assay Development Biochemistry Molecular Biology Protein Chemistry In Vitro Fluorescence Cell Biology Protein Expression Protein Purification Validation ELISA Molecular Cloning DNA Bioinformatics Parkinson's Diabetes Cancer