Mark G Richardson

US Patent:

51908719, Mar 2, 1993

Filed:

Jun 12, 1989

Appl. No.:

7/364959

Inventors:

Karen L. Cox - Martinsville IN
Stuart A. Kuhstoss - Indianapolis IN
R. Nagaraja Rao - Indianapolis IN
Mark A. Richardson - Indianapolis IN
Brigitte E. Schoner - Monrovia IN
Eugene T. Seno - Indianapolis IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

C12N 1574
C12N 121
C12N 1509
C12N 1563

US Classification:

4351723

Abstract:

The present invention provides a method for transforming an actinomycete with an integrating vector which has the advantages of high transformation rates into a broad host range, site-specific integration, and stable maintenance without antibiotic selection. Also provided are methods for the increased production of antibiotics and for the production of hybrid antibiotics.

US Patent:

59487950, Sep 7, 1999

Filed:

Jun 25, 1997

Appl. No.:

8/882711

Inventors:

David Thompson Berg - Beech Grove IN
George Joseph Cullinan - Trafalgar IN
Brian William Grinnell - Indianapolis IN
Mark Alan Richardson - Bloomington IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K 31445
A61K 3140
C07D40912

US Classification:

514324

Abstract:

Novel benzothiophenes, ##STR1## wherein R. sub. 1, R. sub. 2, and R. sub. 3 are independently --OH, --OCO(C. sub. 1 -C. sub. 6 alkyl), --O(CO)O(C. sub. 1 -C. sub. 6 alkyl), --OCO--Ar, where Ar is phenyl or substituted phenyl, or --O(CO)O--phenyl; and R. sub. 4 is N-pyrrolidinyl, N-piperidinyl, or N-hexamethyleneimino, and intermediates thereof, and the uses and formulations thereof, are provided by the present invention.

US Patent:

57313288, Mar 24, 1998

Filed:

Sep 4, 1996

Appl. No.:

8/708868

Inventors:

David Thompson Berg - Beech Grove IN
Brian William Grinnell - Indianapolis IN
Mark Alan Richardson - Bloomington IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K 31445
A61K 3140
A61K 3155

US Classification:

514324

Abstract:

A method of inhibiting plasminogen activator inhibitor 1 comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR1## wherein R. sup. 1 and R. sup. 3 are independently hydrogen, --CH. sub. 3, ##STR2## wherein Ar is optionally substituted phenyl; R. sup. 2 is selected from the group consisting of pyrrolidine, hexamethyleneimino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.

US Patent:

59809388, Nov 9, 1999

Filed:

Jun 25, 1997

Appl. No.:

8/882673

Inventors:

David Thompson Berg - Beech Grove IN
George Joseph Cullinan - Trafalgar IN
Brian William Grinnell - Indianapolis IN
Mark Alan Richardson - Bloomington IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K 948

US Classification:

424451

Abstract:

The present invention provides methods of inhibiting PAI-1 using benzopyrans.

US Patent:

57806489, Jul 14, 1998

Filed:

Jun 25, 1997

Appl. No.:

8/882674

Inventors:

David Thompson Berg - Beech Grove IN
George Joseph Cullinan - Trafalgar IN
Brian William Grinnell - Indianapolis IN
Mark Alan Richardson - Bloomington IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

C07D33356
C07D33364
A61K 3138

US Classification:

549 57

Abstract:

Benzothiophenes, and uses and formulations thereof, are provided by the present invention.

US Patent:

45593000, Dec 17, 1985

Filed:

Jan 18, 1983

Appl. No.:

6/458803

Inventors:

Steven Kovacevic - Indianapolis IN
Jeffrey T. Fayerman - Indianapolis IN
James R. Miller - Indianapolis IN
Mark A. Richardson - Indianapolis IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

C12P 2100
C12N 1500
C12N 120
C12N 100

US Classification:

435 68

Abstract:

A method for expressing a functional polypeptide in Streptomyces comprises transforming a Streptomyces host cell with a recombinant DNA expression vector and then culturing the transformed cell under conditions suitable for cell growth. The recombinant DNA expression vector comprises the veg or any other homologous Bacillus promoter, a naturally occurring or modified ribosome binding site-containing DNA sequence and a gene that codes for a functional polypeptide such as human pre-proinsulin. The method is specifically exemplified by use of expression plasmids pOW529, pOW539 and transformants, Streptomyces ambofaciens/pOW529 and Streptomyces ambofaciens/pOW539. The method is broadly applicable and is particularly useful in economically important Streptomyces taxa.

US Patent:

50988379, Mar 24, 1992

Filed:

Jun 7, 1988

Appl. No.:

7/203387

Inventors:

Robert J. Beckmann - Indianapolis IN
Karen L. Cox - Martinsville IN
R. Nagaraja Rao - Indianapolis IN
Mark A. Richardson - Indianapolis IN
Eugene T. Seno - Indianpolis IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

C12N 121
C12N 1509
C12N 1576

US Classification:

4351723

Abstract:

Spiramycin antibiotic biosynthetic genes of Streptomyces ambofaciens are provided by the present invention, in addition to a variety of recombinant DNA vectors. The genes also function in other macrolide producing organisms. The genes can be used to increase or otherwise alter the macrolide antibiotic-producing ability of an organism. The present invention also provides host strains comprising mutant spiramycin biosynthetic genes which can be used to generate novel antibiotics. Also provided is a method for preparing the mutant gene comprising mutating cloned spiramycin biosynthetic DNA by transposon mutagenesis with subsequent transformation into a macrolide-antibiotic producing host and homologous recombination into its genome, to generate stable mutant cell lines.

US Patent:

48867578, Dec 12, 1989

Filed:

Apr 15, 1987

Appl. No.:

7/038689

Inventors:

Mark A. Richardson - Indianapolis IN

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

C12N 1500
C12N 120

US Classification:

4352523

Abstract:

A novel gene conferring resistance to spiramycin in Streptomyces and related organisms was cloned from a genomic library of Streptomyces ambofaciens DNA. A thirty-one Kb fragment of S. ambofaciens DNA including the spiramycin-resistance gene was isolated from this library on a cosmid designated pKC592. The novel spiramycin-resistance gene can be isolated on an. about. 2. 9 Kb BamHI fragment by subcloning restriction fragments obtained from the pKC592 insert DNA. This BamHI fragment contains all of the information required for the expression of the spiramycin resistant phenotype in Streptomyces. Vectors and transformants containing the novel spiramycin resistance gene are provided.

Address:

5907 Jamestown Sq Ln, Indianapolis, IN 46234

Phone:

(317)6258268

VIN:

3FAHP0JA5CR105634

Make:

FORD

Model:

FUSION

Year:

2012

Address:

2716 Shakespeare Dr, Indianapolis, IN 46227

VIN:

1G2ZH57N084120551

Make:

PONTIAC

Model:

G6

Year:

2008

Address:

10365 E Shop Dr, Rockville, IN 47872

VIN:

2HJYK16577H522129

Make:

HONDA

Model:

RIDGELINE

Year:

2007