Nai J Wang

US Patent:

6348207, Feb 19, 2002

Filed:

Sep 30, 1997

Appl. No.:

08/941609

Inventors:

Sam J. Milstein - Larchmont NY
Evgueni Barantsevitch - New Rochelle NY
Nai Fang Wang - Long Island City NY
Donald J. Sarubbi - Bronxville NY
Noemi B Santiago - Hawthorne NY

Assignee:

Emisiphere Technologies, Inc. - Tarrytown NY

International Classification:

A01N 2512

US Classification:

424408, 424409, 424489, 424498, 424499, 424451, 424464, 424470

Abstract:

Methods for transporting a biologically active agent across a cellular membrane or a lipid bilayer. A first method includes the steps of: (a) providing a biologically active agent which can exist in a native conformational state, a denatured conformational state, and an intermediate conformational state which is reversible to the native state and which is conformationally between the native and denatured states; (b) exposing the biologically active agent to a complexing perturbant to reversibly transform the biologically active agent to the intermediate state and to form a transportable supramolecular complex; and (c) exposing the membrane or bilayer to the supramolecular complex, to transport the biologically active agent across the membrane or bilayer. The perturbant has a molecular weight between about 150 and about 600 daltons, and contains at least one hydrophilic moiety and at least one hydrophobic moiety. The supramolecular complex comprises the perturbant non-covalently bound or complexed with the biologically active agent.

US Patent:

6627228, Sep 30, 2003

Filed:

Oct 9, 2001

Appl. No.:

09/889005

Inventors:

Sam J. Milstein - Larchmont NY
Eugene N. Barantsevitch - Scarsdale NY
Nai Fang Wang - Long Island City NY
Jun Liao - Tarrytown NY
John E. Smart - Katonah NY
Richard D. Conticello - Ossining NY
Raphael M. Ottenbrite - Midlothian VA

Assignee:

Emisphere Technologies, Inc. - Tarrytown NY

International Classification:

A61K 914

US Classification:

424489, 424 7816, 424451, 424452, 424464, 424465

Abstract:

Polymeric delivery agents, delivery agent compounds and compositions comprising them which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.

US Patent:

6916489, Jul 12, 2005

Filed:

Sep 25, 2002

Appl. No.:

10/255237

Inventors:

Sam J. Milstein - Larchmont NY, US
Evgueni Barantsevitch - New Rochelle NY, US
Nai Fang Wang - Long Island City NY, US
Donald J. Sarubbi - Bronxville NY, US
Noemi B Santiago - Hawthorne NY, US

Assignee:

Emisphere Technologies, Inc. - Tarrytown NY

International Classification:

A61K009/27
A61K009/48
A61K009/20
A61K009/16

US Classification:

424450, 424451, 424464, 424488, 424489, 424490, 424491

Abstract:

Methods for transporting a biologically active agent across a cellular membrane or a lipid bilayer. A first method includes the steps of:Additionally, mimetics and methods for preparing mimetics are contemplated.

US Patent:

6991798, Jan 31, 2006

Filed:

Aug 6, 1999

Appl. No.:

09/762067

Inventors:

David Gschneidner - Stamford CT, US
Eric Wang - Perryhall MD, US
Lynn Errigo - Port Chester NY, US
Jeffrey Bruce Press - Brewster NY, US
Nai Fang Wang - Long Island City NY, US
Pingwah Tang - Elmsford NY, US

Assignee:

Emisphere Technologies, Inc. - Tarrytown NY

International Classification:

A61K 38/00

US Classification:

424400

Abstract:

Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.

US Patent:

7186414, Mar 6, 2007

Filed:

Jun 30, 2005

Appl. No.:

11/173075

Inventors:

David Gschneidner - Stamford CT, US
Eric Wang - Ellicott City MD, US
Lynn Errigo - Port Chester NY, US
Jeffrey Bruce Press - Brewster NY, US
Nai Fang Wang - Long Island City NY, US
Pingwah Tang - Elmsford NY, US

Assignee:

Emisphere Technologies, Inc - TarryTown NY

International Classification:

A61K 38/00
A61K 9/00
A61K 51/00
A61F 13/00
A01N 37/18
A61M 36/14

US Classification:

424400, 424 169, 424422, 514 2

Abstract:

Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.

US Patent:

7208483, Apr 24, 2007

Filed:

May 28, 2003

Appl. No.:

10/447608

Inventors:

Sam J. Milstein - Larchmont NY, US
Eugene N. Barantsevitch - Scarsdale NY, US
Nai Fang Wang - Long Island City NY, US
Jun Liao - Tarrytown NY, US
John E. Smart - Katonah NY, US
Richard D. Conticello - Ossining NY, US
Raphael M. Ottenbrite - Midlothian VA, US

Assignee:

Emisphere Technologies, Inc. - Tarrytown NY

International Classification:

A07N 43/30

US Classification:

514166, 514159, 424400

Abstract:

Polymeric delivery agents, delivery agent compounds and compositions comprising them which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.

US Patent:

7700775, Apr 20, 2010

Filed:

Mar 1, 2002

Appl. No.:

10/469500

Inventors:

Jun Liao - Tarrytown NY, US
David Gschneidner - Tarrytown NY, US
John J. Weidner - Tarrytown NY, US
Nai Fang Wang - Tarrytown NY, US

Assignee:

Emisphere Technologies, Inc. - Tarrytown NY

International Classification:

C07C 233/00

US Classification:

546167, 544169, 544222, 544388, 544391, 546337, 5483461

Abstract:

Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.

US Patent:

7727558, Jun 1, 2010

Filed:

Jan 31, 2007

Appl. No.:

11/669649

Inventors:

Sam J. Milstein - Larchmont NY, US
Eugene N. Barantsevitch - Scarsdale NY, US
Nai Fang Wang - Long Island City NY, US
Jun Liao - Yorktown Heights NY, US
John Smart - Katonah NY, US
Richard Conticello - Ossining NY, US
Raphael Ottenbrite - Midlothian VA, US

Assignee:

Emisphere Technologies, Inc. - Tarrytown NY
Virginia Commonwealth University - Richmond VA

International Classification:

A61K 9/50

US Classification:

424501

Abstract:

Polymeric delivery agents, delivery agent compounds and compositions comprising them which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.