Peter Nathaniel Davis

US Patent:

6558633, May 6, 2003

Filed:

Sep 21, 1994

Appl. No.:

08/309925

Inventors:

David J. Ecker - Leucadia CA
Oscar Acevedo - San Diego CA
Normand Hebert - Cardiff CA
Peter W. Davis - Carlsbad CA
Jacqueline R. Wyatt - Carlsbad CA
John S. Kiely - San Diego CA

Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

C12M 118

US Classification:

422134, 422 50, 422131, 4352885, 4352884, 4353052

Abstract:

Chemical reaction apparatus, materials and methods are provided for the automatable, efficient synthesis of chemical species and libraries. In accordance with preferred embodiments, chemical droplet generation and direction techniques are employed to prepare oligomers and libraries of chemical species. Reaction assemblies adapted for efficient synthetic employment and for improved collection are also disclosed.

US Patent:

20010028866, Oct 11, 2001

Filed:

May 23, 2001

Appl. No.:

09/863158

Inventors:

David Ecker - Leucadia CA, US
Oscar Acevedo - San Diego CA, US
Normand Hebert - Cardiff CA, US
Peter Davis - Carlsbad CA, US
Jacqueline Wyatt - Carlsbad CA, US
John Kiely - San Diego CA, US

Assignee:

ISIS Pharmaceuticals, Inc.

International Classification:

B01J019/00

US Classification:

422/131000

Abstract:

Chemical reaction apparatus, materials and methods are provided for the automatable, efficient synthesis of chemical species and libraries. In accordance with preferred embodiments, chemical droplet generation and direction techniques are employed to prepare oligomers and libraries of chemical species. Reaction assemblies adapted for efficient synthetic employment and for improved collection are also disclosed.

US Patent:

59257326, Jul 20, 1999

Filed:

Jan 2, 1997

Appl. No.:

8/778876

Inventors:

David J. Ecker - Leucadia CA
Oscar Acevedo - San Diego CA
Normand Hebert - Cardiff CA
Peter W. Davis - Carlsbad CA
Jacqueline R. Wyatt - Carlsbad CA
John S. Kiely - San Diego CA

Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

G01N 3353
C12Q 168
C07K 104
C07H 2100

US Classification:

530334

Abstract:

Chemical reaction apparatus, materials and methods are provided for the automatable, efficient synthesis of chemical species and libraries. In accordance with preferred embodiments, chemical droplet generation and direction techniques are employed to prepare oligomers and libraries of chemical species. Reaction assemblies adapted for efficient synthetic employment and for improved collection are also disclosed.

US Patent:

56983913, Dec 16, 1997

Filed:

Dec 16, 1994

Appl. No.:

8/357396

Inventors:

Phillip Dan Cook - San Marcos CA
David J. Ecker - Leucadia CA
Jacqueline Wyatt - Carlsbad CA
Thomas W. Bruice - Carlsbad CA
Kevin Anderson - Carlsbad CA
Ronnie Hanecak - San Clemente CA
Timothy Vickers - Oceanside CA
Peter Davis - Carlsbad CA
Susan M. Freier - San Diego CA
Yogesh S. Sanghvi - San Marcos CA
Vickie Brown-Driver - San Diego CA

Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

C12Q 168
C12Q 170

US Classification:

435 5

Abstract:

Methods useful for the determination of oligomers which have specific activity for a target molecule from a pool of primarily randomly assembled oligomers are provided. The disclosed methods involve repeated syntheses of increasingly simplified sets of oligomers coupled with selection procedures for determining oligomers having the highest activity. Freedom from the use of enzymes allows the application of these methods to any molecules which can be oligomerized in a controlled fashion.

US Patent:

56724721, Sep 30, 1997

Filed:

Feb 22, 1994

Appl. No.:

8/196103

Inventors:

David J. Ecker - Leucadia CA
Jacqueline Wyatt - Carlsbad CA
Thomas W. Bruice - Carlsbad CA
Kevin Anderson - Carlsbad CA
Ronnie C. Hanecak - San Clemente CA
Timothy Vickers - Oceanside CA
Peter Davis - Carlsbad CA

Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

C12Q 170
C12Q 168
C07H 2100
C12P 1934

US Classification:

435 6

Abstract:

Methods useful for the determination of oligomers which have specific activity for a target molecule from a pool of primarily randomly assembled subunits are provided. The disclosed methods involve repeated syntheses of increasingly simplified sets of oligomers coupled with selection procedures for determining oligomers having the highest activity. Freedom from the use of enzymes allows the application of these methods to any molecules which can be oligomerized in a controlled fashion.

US Patent:

62773348, Aug 21, 2001

Filed:

May 18, 1999

Appl. No.:

9/313403

Inventors:

David J. Ecker - Leucadia CA
Oscar Acevedo - San Diego CA
Normand Hebert - Cardiff CA
Peter W. Davis - Carlsbad CA
Jacqueline R. Wyatt - Carlsbad CA
John S. Kiely - San Diego CA

Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

B01L 300
G01N 3353

US Classification:

422131

Abstract:

Chemical reaction apparatus, materials and methods are provided for the automatable, efficient synthesis of chemical species and libraries. In accordance with preferred embodiments, chemical droplet generation and direction techniques are employed to prepare oligomers and libraries of chemical species. Reaction assemblies adapted for efficient synthetic employment and for improved collection are also disclosed.

US Patent:

58861777, Mar 23, 1999

Filed:

Aug 8, 1996

Appl. No.:

8/669506

Inventors:

Phillip Dan Cook - Vista CA
Oscar L. Acevedo - San Diego CA
Peter W. Davis - Carlsbad CA
David J. Ecker - Encinitas CA
Normand Hebert - Cardiff CA

Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

C07D23700

US Classification:

544224

Abstract:

Novel ethylene glycol compounds bearing various functional groups are used to prepare oligomeric structures. The ethylene glycol monomers can be joined via standard phosphate linkages including phosphorothioate, phosphodiester, and phosphoramidate linkages. Useful functional groups include nucleobases as well as polar groups, hydrophobic groups, ionic groups, aromatic groups and/or groups that participate in hydrogen-bonding.

US Patent:

20210102503, Apr 8, 2021

Filed:

Oct 8, 2019

Appl. No.:

16/596453

Inventors:

- San Diego CA, US
Peter Davis - San Diego CA, US

Assignee:

Solar Turbines Incorporated - San Diego CA

International Classification:

F02C 9/28
F02C 7/22

Abstract:

A method and control system for controlling compressor output for a gas turbine engine is disclosed. The power output of a gas turbine engine can vary and be below desired output levels due to operating conditions such as ambient temperature and elevation. These operating conditions can lead to lower output of the gas compressor of the turbine engine and lower operating temperatures within or proximate to a turbine of the gas turbine engine and lead to less power output. Additional fuel can be added to increase power to the gas producer shaft and increase turbine temperature of the gas turbine engine. A power transfer device can be used to remove or add power to the gas producer shaft to balance the gas producer mechanical limits and turbine thermal limits at maximum levels and lead to higher power output.