Wen B Xie

US Patent:

20080085879, Apr 10, 2008

Filed:

Aug 29, 2007

Appl. No.:

11/847163

Inventors:

Wen Xie - Pittsburgh PA, US
Haibiao Gong - Pittsburgh PA, US

Assignee:

University of Pittsburgh - Of the Commonwealth System of Higher Education - Pittsburgh PA

International Classification:

A61K 31/56
A61P 35/00

US Classification:

514182000

Abstract:

The invention provides a method of treating an estrogen responsive condition comprising administration of an agonist of an orphan nuclear receptor, wherein activation of the orphan nuclear receptor inhibits estrogen activity. The invention also provides a method of reducing the size of an estrogen responsive tumor comprising administration of an agonist of an orphan nuclear receptor, wherein activation of the orphan nuclear receptor inhibits estrogen activity. The invention also provides a pharmaceutical composition comprising an agonist of an orphan nuclear receptor and a pharmaceutically acceptable vehicle, wherein activation of the orphan nuclear receptor inhibits estrogen activity.

US Patent:

20120003335, Jan 5, 2012

Filed:

Nov 18, 2009

Appl. No.:

13/129711

Inventors:

Wen Xie - Pittsburgh PA, US
Jie Gao - Pittsburgh PA, US

Assignee:

UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION - Pittsburgh PA

International Classification:

A61K 36/282
A61K 31/515
A61K 31/37
A61P 3/10
A61K 31/429
A61K 31/7088
A61K 31/421
A61P 3/04
A61K 31/444
A61K 31/497

US Classification:

424740, 514335, 514270, 514457, 51425505, 514368, 514 44 R, 514374

Abstract:

The invention provides a method of controlling obesity or type two diabetes in a human. In accordance with the inventive method, the constitutive androstane receptor (CAR) is agonized within the human, which effectively controls obesity or type two diabetes.