Xiao Xia Chen

US Patent:

20030082660, May 1, 2003

Filed:

Sep 9, 2002

Appl. No.:

10/237563

Inventors:

Robert Horlick - San Diego CA, US
Robert Swanson - Cranbury NJ, US
Maria Webb - Flemington NJ, US
Barbara Strohl - Hamilton NJ, US
John Baldwin - Gwynedd Valley PA, US
Douglas Auld - Cranbury NJ, US
Xiao Chen - Princeton NJ, US

International Classification:

G01N033/53
G01N033/537
G01N033/543
C07H021/04
C12P021/02
C12N005/06
C07K014/705
C07K014/575

US Classification:

435/007930, 435/069100, 435/320100, 435/325000, 536/023200, 530/324000, 530/350000

Abstract:

Methods for identifying modulators of receptor activity using orthologues of human receptors are described. Additionally, a method for identifying an animal model useful in the screening of potential therapeutic agents is provided. The genes for bradykinin Breceptors from five mammalian species, vervet monkey, rhesus macaque, tree shrew, dog and pig, as well as the genes for CXCR2 receptors from chimpanzee, gorilla, orangutan, rhesus, vervet and baboon have been cloned and characterized and are described herein.

US Patent:

20210166781, Jun 3, 2021

Filed:

Aug 26, 2020

Appl. No.:

17/003856

Inventors:

- San Diego CA, US
Xiao Chen - San Diego CA, US

International Classification:

G16B 20/10
G16B 30/10
G16B 20/20
G16B 5/20

Abstract:

Disclosed herein include systems, devices, computer readable media, and methods for paralog genotyping, such as determining a copy number of survival of motor neuron 1 gene and genotyping cytochrome P450 family 2 subfamily D member 6 gene using a Gaussian mixture model comprising a plurality of Gaussians each representing a different integer copy number.

US Patent:

20200090784, Mar 19, 2020

Filed:

Jan 16, 2018

Appl. No.:

16/467228

Inventors:

- San Diego CA, US
Han-Yu Chuang - San Diego CA, US
Gwenn Berry - San Diego CA, US
Xiao Chen - San Diego CA, US

International Classification:

G16B 20/20
G16B 30/10
C12N 15/10
C12Q 1/6809
C12Q 1/6886

Abstract:

Presented herein are systems and methods for identifying splice variants. The techniques include determining one or more sample splice junctions from a plurality of RNA sequence reads from a single biological sample, retrieving a set of baseline splice junctions determined from a plurality of healthy RNA samples and comparing the one or more sample splice junctions to the set of baseline splice junctions to identify one or more filtered sample splice junctions comprising sample splice junctions that do not overlap with the baseline splice junctions, wherein the one or more filtered sample splice junctions are candidate oncogenic events.

US Patent:

20190287647, Sep 19, 2019

Filed:

Nov 15, 2017

Appl. No.:

16/349152

Inventors:

- San Diego CA, US
Han-Yu CHUANG - San Diego CA, US
Jessica GORDON - San Diego CA, US
Xiao CHEN - San Diego CA, US
Stephen TANNER - San Diego CA, US

Assignee:

ILLUMINA, INC. - San Diego CA

International Classification:

G16B 30/10

Abstract:

Sequencing data read realignment. A method obtains from a sequence alignment dataset an initial alignment of a read sequence to a reference sequence and performs realignment processing on the initial alignment. The realignment processing includes identifying candidate indel(s) that include zero or more indels in the aligned read and zero or more indels aligned proximal to the aligned read as indicated by the sequence alignment dataset, creating a flattened aligned read based at least on removing from the aligned read any indels indicated by the initial alignment, and determining candidate realignment(s) of the read sequence to the reference sequence based on introducing, for each candidate realignment of the candidate realignment(s), a respective at least one candidate indel of the candidate indel(s) into the flattened aligned read. The method further provides the initial alignment or a selected candidate realignment of the candidate realignment(s) based on selection criteria.