Aaron Abraham Miller

US Patent:

7173134, Feb 6, 2007

Filed:

Sep 16, 2002

Appl. No.:

10/490805

Inventors:

Curt Dale Haffner - Durham NC, US
Istvan Kaldor - Durham NC, US
Darryl Lynn McDougald - Durham NC, US
Aaron Bayne Miller - Durham NC, US

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C07D 491/048
C07D 263/56
C07D 307/80
C07D 307/85
C07D 333/56
C07D 405/04
C07D 411/04

US Classification:

546115, 548183, 548217, 548465, 549 58, 549468, 549471

Abstract:

The present invention includes novel retinoid compounds that have selectivity as RXR agonists on one or more isoforms of RXR, currently, RXRα, RXRβ, or RXRγ. The present compounds, and pharmaceutical compositions incorporating these compounds, therefore, are effective in treating conditions mediated by RXRs. Among other physiological responses, the compounds of the present invention reduce blood glucose and maintain body weight, and, thus, are useful for the treatment of diabetes (NIDDIM) and obesity.

US Patent:

7282512, Oct 16, 2007

Filed:

Jan 15, 2003

Appl. No.:

10/501636

Inventors:

John George Catalano - Durham NC, US
David Norman Deaton - Durham NC, US
Aaron Bayne Miller - Durham NC, US
Francis Xavier Tavares - Durham NC, US

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

A61K 31/41
C07D 233/00

US Classification:

514362, 514365, 514385, 514396, 514403, 5483164, 548186, 548152, 548128

Abstract:

Cycloalkyl ketoamide derivatives, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such cycloalkyl ketoamide derivatives as well as methods of using the same in the treatment of disorders, including osteoporosis, associated with enhanced bone turnover which can ultimately lead to fracture.

US Patent:

7402606, Jul 22, 2008

Filed:

Apr 1, 2003

Appl. No.:

10/510469

Inventors:

David Gene Barrett - Henstedt-Ulzburg, DE
John G. Catalano - Durham NC, US
David Norman Deaton - Durham NC, US
Aaron Bayne Miller - Durham NC, US
John A. Ray - Durham NC, US
Vicente Samano - Durham NC, US

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

A61K 31/341
A61K 31/4015
A61K 31/4025
A61K 31/404
A61K 31/4155
A61K 31/416
A61K 31/4192
A61K 31/4196
A61K 31/4245
A61K 31/42
A61K 31/433
A61K 31/4439
A61K 31/4709
A61K 31/497
A61K 31/5377

US Classification:

514424, 514423, 514414, 514406, 514378, 514367, 514365, 514361, 514364, 514363, 514314, 514343, 51425505, 5142355, 544141, 544405, 5462784, 546168, 5462704, 548544, 548556, 548525, 548127, 548236, 548255, 548261, 548468, 548248, 5482668, 5483625, 548247, 548203, 548131, 548162, 549475

Abstract:

Heterocycle substituted ketoamide derivatives of Formula (I), wherein the substitutes A, D, A and R are defined as in claim in, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such heterocycle substituted ketoamide derivatives as well as method of using the same in the manufacture of medicaments for the treatment of disorders, including osteoporosis, associated with an imbalance between bone resorption and formation which can ultimately lead to fracture.

US Patent:

7405303, Jul 29, 2008

Filed:

Feb 22, 2005

Appl. No.:

10/598246

Inventors:

William Joel Hoekstra - Durham NC, US
Aaron Bayne Miller - Durham NC, US
William John Zuercher - Durham NC, US
Harikrishna Suryakant Patel - Durham NC, US

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C07D 215/00
A61K 31/4709

US Classification:

546173, 514312

Abstract:

The present invention relates to novel compounds of formula (I) with a variety of therapeutic uses, more particularly novel substituted quinoline compounds particularly useful for selective estrogen receptor modulation.

US Patent:

7560589, Jul 14, 2009

Filed:

Jul 27, 2004

Appl. No.:

10/565296

Inventors:

Jonathan E. Britton - Skyland NC, US
Jing Fang - Durham NC, US
Dennis Heyer - Durham NC, US
Aaron Bayne Miller - Durham NC, US
Frank Navas, III - Durham NC, US
William J. Zuercher - Durham NC, US
Subba Reddy Katamreddy - Durham NC, US

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C07C 63/33

US Classification:

562491

Abstract:

The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel substituted cyclic alkylidene compounds that are particularly useful for selective estrogen receptor modulation.

US Patent:

7569601, Aug 4, 2009

Filed:

May 14, 2007

Appl. No.:

11/748096

Inventors:

Jing Fang - Durham NC, US
Dennis Heyer - Durham NC, US
Aaron Bayne Miller - Durham NC, US
Frank Navas, III - Durham NC, US
William J. Zuercher - Durham NC, US
Subba Reddy Katamreddy - Durham NC, US

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

A61K 31/351
C07D 315/00

US Classification:

514459, 549426

Abstract:

The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel substituted cyclic alkylidene compounds that are particularly useful for selective estrogen receptor modulation.

US Patent:

7649093, Jan 19, 2010

Filed:

Jun 21, 2005

Appl. No.:

11/570838

Inventors:

Dennis Heyer - Durham NC, US
Jing Fang - Durham NC, US
Frank Navas, III - Durham NC, US
Subba Reddy Katamreddy - Durham NC, US
Jennifer Poole Peckham - Durham NC, US
Philip Stewart Turnbull - Durham NC, US
Aaron Bayne Miller - Durham NC, US
Adwoa Akwabi-Ameyaw - Durham NC, US

Assignee:

Glaxo Smith Kline LLC - Wilmington DE

International Classification:

C07D 471/00
C07D 295/00
A61K 31/445

US Classification:

546 86, 514319, 544386

Abstract:

The present invention relates to cycloalkylidene compounds with a variety of therapeutic uses, more particularly novel naphthalene compounds that are particularly useful for selective estrogen receptor modulation.

US Patent:

7799828, Sep 21, 2010

Filed:

Jun 8, 2009

Appl. No.:

12/480097

Inventors:

Jing Fang - Durham NC, US
Dennis Heyer - Durham NC, US
Aaron Bayne Miller - Durham NC, US
Frank Navas, III - Durham NC, US
William J. Zuercher - Durham NC, US
Subba Reddy Katamreddy - Durham NC, US

Assignee:

GlaxoSmithKline LLC - Philadelphia PA

International Classification:

A61K 31/351

US Classification:

514459

Abstract:

The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel substituted cyclic alkylidene compounds that are particularly useful for selective estrogen receptor modulation.