Abdolhossen H Talebian

US Patent:

47644621, Aug 16, 1988

Filed:

Aug 23, 1985

Appl. No.:

6/768832

Inventors:

Reinhard Bredehorst - Washington DC
Abdolhossen Talebian - Arlington VA
Charles F. Hammer - Washington DC
Carl-Wilhelm Vogel - Washington DC

Assignee:

Georgetown University - Washington DC

International Classification:

C12Q 134
C12Q 102
C12Q 104
C12Q 106
C12Q 110
C12N 996

US Classification:

435 18

Abstract:

This invention provides for a cephalosporin immobilized on a solid phase support comprising a beta-lactamase releasable, detectably labeled substituent at the 3-position thereof. This invention also provides for an assay for detecting the presence of beta-lactamase enzyme in a sample comprising: (a) immobilizing a cephalosporin on a solid phase support wherein at the 3-position of said cephalosporin is a detectably labeled substituent releasable by beta-lactamase; (b) contacting said sample with the immobilized cephalosporin of step (a); and, (c) detecting the released substituent.

US Patent:

48959359, Jan 23, 1990

Filed:

Jan 14, 1988

Appl. No.:

7/143762

Inventors:

Abdolhossen Talebian - Herndon VA
Dianna C. Green - Falls Church VA
Charles F. Hammer - Washington DC
Philip S. Schein - Bryn Mawr PA

Assignee:

Georgetown University - Washington DC

International Classification:

C07H 1500
C07H 2300

US Classification:

536 171

Abstract:

Platinum compounds of the formulae: ##STR1## are disclosed. Compositions containing these compounds and methods of using the same in the treatment of tumors are also discussed.

US Patent:

49564595, Sep 11, 1990

Filed:

Jan 14, 1988

Appl. No.:

7/143763

Inventors:

Abdolhossen Talebian - Herndon VA
Dianna C. Green - Falls Church VA
Charles F. Hammer - Washington DC
Philip S. Schein - Bryn Mawr PA

Assignee:

Georgetown University - Washington DC

International Classification:

A61K 3128
A61K 3170
C07H 2300

US Classification:

536121

Abstract:

Compounds of the formula: ##STR1## wherein each of R. sub. 1 and R. sub. 2 is independently selected from the group consisting of halogen, hydroxy, or mono carboxylic acid or R. sub. 1 and R. sub. 2 together is a multifunctional carboxylic acid residue which forms a ring with the platinum atom through two oxygens of said multifunctional carboxylic acid; R. sub. 3 is a deoxy mono or disaccharide or a derivative thereof; and R. sub. 4 is selected from the group consisting of hydrogen, C. sub. 1-4 -alkyl, phenyl, benzyl, substituted phenyl or substituted benzyl, wherein substituents are selected from the group consisting of halogen, nitro, C. sub. 1-2 -alkoxy, carboxy, carbony ester or phenyl or a pharmaceutically acceptable salt thereof are disclosed. Compositions containing these compounds and methods using these compounds are also discussed.

US Patent:

48959367, Jan 23, 1990

Filed:

Jan 14, 1988

Appl. No.:

7/143761

Inventors:

Abdolhossen Talebian - Herndon VA
Dianna C. Green - Falls Church VA
Philip S. Schein - Bryn Mawr PA

Assignee:

Georgetown University - Washington DC

International Classification:

C07H 1500
C07H 2300

US Classification:

536 171

Abstract:

Platinum compounds useful in the treatment of cancer are disclosed. Compositions containing these compounds and methods of using the same are also discussed. The compound have the formula: ##STR1## wherein n is 0 or 1, R. sub. 1 is selected from the group consisting of hydrogen, a mono or disaccharide or a derivative thereof linked to the nitrogen atom by a --NHCO-amide moiety, an --NHCS-- thioamide moeity or a --CO-- carbonylmoiety, R' is selected from the group consisting of hydrogen and C. sub. 1-4 alkyl, and R. sub. 2 and R. sub. 3 are selected from the group consisting of hydrogen, C. sub. 1-4 alkyl or R. sub. 2 and R. sub. 3 or R. sub. 2 and R. sub. 3 together are linked to adjacent carbon atoms on a four, five or six membered ring structure, or R. sub. 2 and R. sub. 3 together form a fused or bicyclic ring with adjacent carbon atoms; with the proviso that R' and R. sub. 1 cannot both be hydrogen when n=o, or a pharmaceutically acceptable salt thereof.

US Patent:

50915231, Feb 25, 1992

Filed:

Dec 3, 1990

Appl. No.:

7/620853

Inventors:

Abdolhossen Talebian - Herndon VA
Dianna Green - Falls Church VA
Charles Hammer - Washington DC
Philip Schein - Bryn Mawr PA
Alem Ghiorghis - Washington DC
Robert R. Clarke - Bethesda MD

Assignee:

Georgetown University - Washington DC

International Classification:

A61K 3140
A61K 2100
C07D48714

US Classification:

536 173

Abstract:

The invention relates to certain derivatives of mitomycins A and C and the use thereof to treat bacterial infections and to supress the growth of cancer cells. The invention also relates to processes for the preparation of the mitomycin derivatives of the invention.

US Patent:

49469541, Aug 7, 1990

Filed:

Jan 26, 1989

Appl. No.:

7/301773

Inventors:

Abdolhossen Talebian - Herndon VA
Dianna C. Green - Falls Church VA
Philip S. Schein - Bryn Mawr PA

Assignee:

Georgetown University - Washington DC

International Classification:

C07H 1500
C07H 2300

US Classification:

536121

Abstract:

Platinum compounds useful in the treatment of cancer are disclosed. Compositions containing these compounds and methods of using the same are also discussed. Compounds having the formula ##STR1## wherein n is 0 or 1 and when n is 1 R. sub. 1 is H or C. sub. 1 -C. sub. 4 alkyl, R is non-substituted higher alkyl or mono or disaccharide or a derivative of a mono or disaccharide, when n is O, R. sub. 1 is H or C. sub. 1 -C. sub. 4 alkyl, R is H, halogen, non-substituted C. sub. 1 -. sub. 20 alkyl, aryl, arlalkyloxy, mono or disaccharide, or a derivative of a mono or disaccharide, and R. sub. 2 and R. sub. 3 are selected from the group consisting of hydrogen, C. sub. 1. sup. -4 alkyl or R. sub. 2 and R. sub. 3 or R. sub. 2 and R. sub. 3 together are linked to adjacent carbon atoms on a four, five or six membered ring structure, or R. sub. 2 and R. sub.