Adam J Bell

US Patent:

20040254101, Dec 16, 2004

Filed:

Nov 12, 2002

Appl. No.:

10/291773

Inventors:

Patrick Dillon - Carlsbad CA, US
Yi Li - Sunnyvale CA, US
Daniel Soppet - Centreville VA, US
Adam Bell - Germantown MD, US
D. Duan - Bethesda MD, US
Ralph Alderson - Gaithersburg MD, US
Wendy Halpern - Darnestown MD, US

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

A61K048/00
A61K038/17

US Classification:

514/012000, 514/044000

Abstract:

Human Colon Specific Polynucleotides (DNA and RNA), Polypeptides, and Antibodies, as well as methods for using and producing such polynucleotides, polypeptides, and antibodies are disclosed. More particularly, methods are disclosed for utilizing such polynucleotides, polypeptides, and antibodies to detect, diagnose, prevent, treat, and/or ameliorate cancer (particularly gastrointestinal tract cancers such as colon and pancreatic cancer). Also disclosed are compositions and methods for targeting and destroying cancer cells (particularly gastrointestinal tract cancers such as colon and pancreatic cancer) via the Colon Specific Protein and/or via the Colon Specific Protein Receptor. Moreover, methods of screening for antagonists and binding partners of the Colon Specific Protein and therapeutic uses of such antagonists and binding partners are also disclosed.

US Patent:

20070178108, Aug 2, 2007

Filed:

Apr 4, 2007

Appl. No.:

11/696199

Inventors:

Patrick Dillon - Carlsbad CA, US
Yi Li - Sunnyvale CA, US
Daniel Soppet - Centreville VA, US
Adam Bell - Germantown MD, US
D. Duan - Bethesda MD, US
Ralph Alderson - Woodside CA, US
Wendy Halpern - Darnestown MD, US

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

A61K 48/00
C12Q 1/68
G01N 33/574
A61K 39/395

US Classification:

424155100, 514044000, 435006000, 435007230

Abstract:

Human Colon Specific Polynucleotides (DNA and RNA), Polypeptides, and Antibodies, as well as methods for using and producing such polynucleotides, polypeptides, and antibodies are disclosed. More particularly, methods are disclosed for utilizing such polynucleotides, polypeptides, and antibodies to detect, diagnose, prevent, treat, and/or ameliorate cancer (particularly gastrointestinal tract cancers such as colon and pancreatic cancer). Also disclosed are compositions and methods for targeting and destroying cancer cells (particularly gastrointestinal tract cancers such as colon and pancreatic cancer) via the Colon Specific Protein and/or via the Colon Specific Protein Receptor. Moreover, methods of screening for antagonists and binding partners of the Colon Specific Protein and therapeutic uses of such antagonists and binding partners are also disclosed.