Adam J Bell

US Patent:

7973139, Jul 5, 2011

Filed:

Mar 25, 2005

Appl. No.:

11/090847

Inventors:

Adam Bell - Germantown MD, US
Craig A. Rosen - Laytonsville MD, US

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C07K 16/00
C07K 14/00
C12N 15/85
C12N 5/12
A61K 39/395

US Classification:

5303879, 5303871, 5303881, 53038822, 5303913, 5303917, 435325, 435326

Abstract:

The present invention relates to antibodies and related molecules that specifically bind to the Nogo receptor (NogoR). Such antibodies have uses, for example, in the treatment of spinal cord injury, brain trauma, paralysis, degenerative nervous system diseases, and stroke. The invention also relates to nucleic acid molecules encoding anti-NogoR antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same.

US Patent:

20030143191, Jul 31, 2003

Filed:

May 24, 2002

Appl. No.:

10/153604

Inventors:

Adam Bell - Germantown MD, US
Steven Ruben - Olney MD, US

International Classification:

A61K038/19
C07K014/52
C07H021/04
C12P021/02
C12N005/06

US Classification:

424/085100, 530/351000, 536/023500, 435/069500, 435/320100, 435/325000

Abstract:

The present invention relates to novel chemokine polypeptides and encoding nucleic acids. More specifically, therapeutic compositions and methods are provided using isolated nucleic acid molecules encoding a human chemokine beta-1 (Ck-1 or Ckb1) polypeptide (previously termed monocyte-colony inhibitory factor (M-CIF), MIP1-, and Hemofiltrate CC chemokine-1 (HCC-1)), and Ckb1 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same. Also provided are methods of treating, preventing, ameliorating diseases using such compounds.

US Patent:

20040253672, Dec 16, 2004

Filed:

Dec 4, 2003

Appl. No.:

10/726699

Inventors:

Steven Ruben - Brookeville MD, US
Adam Bell - Germantown MD, US
Charles Birse - North Potomac MD, US
George Komatsoulis - Silver Spring MD, US
Gil Choi - Rockville MD, US
Henrik Olsen - Gaithersburg MD, US
Jian Ni - Germantown MD, US
Kevin Baker - Darnestown MD, US

International Classification:

C07H021/04
C07K014/705

US Classification:

435/069100, 435/320100, 435/325000, 530/350000, 536/023500

Abstract:

The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

US Patent:

20040254101, Dec 16, 2004

Filed:

Nov 12, 2002

Appl. No.:

10/291773

Inventors:

Patrick Dillon - Carlsbad CA, US
Yi Li - Sunnyvale CA, US
Daniel Soppet - Centreville VA, US
Adam Bell - Germantown MD, US
D. Duan - Bethesda MD, US
Ralph Alderson - Gaithersburg MD, US
Wendy Halpern - Darnestown MD, US

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

A61K048/00
A61K038/17

US Classification:

514/012000, 514/044000

Abstract:

Human Colon Specific Polynucleotides (DNA and RNA), Polypeptides, and Antibodies, as well as methods for using and producing such polynucleotides, polypeptides, and antibodies are disclosed. More particularly, methods are disclosed for utilizing such polynucleotides, polypeptides, and antibodies to detect, diagnose, prevent, treat, and/or ameliorate cancer (particularly gastrointestinal tract cancers such as colon and pancreatic cancer). Also disclosed are compositions and methods for targeting and destroying cancer cells (particularly gastrointestinal tract cancers such as colon and pancreatic cancer) via the Colon Specific Protein and/or via the Colon Specific Protein Receptor. Moreover, methods of screening for antagonists and binding partners of the Colon Specific Protein and therapeutic uses of such antagonists and binding partners are also disclosed.

US Patent:

20050214288, Sep 29, 2005

Filed:

Mar 25, 2005

Appl. No.:

11/090836

Inventors:

Adam Bell - Germantown MD, US
Craig Rosen - Laytonsville MD, US

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

G01N033/53
A61K039/395
C07K016/28

US Classification:

424144100, 435007100, 530388220

Abstract:

The present invention relates to antibodies and related molecules that specifically bind to the Nogo receptor (NogoR). Such antibodies have uses, for example, in the treatment of spinal cord injury, brain trauma, paralysis, degenerative nervous system diseases, and stroke. The invention also relates to nucleic acid molecules encoding anti-NogoR antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same.

US Patent:

20050214289, Sep 29, 2005

Filed:

Mar 25, 2005

Appl. No.:

11/090846

Inventors:

Adam Bell - Germantown MD, US
Craig Rosen - Laytonsville MD, US

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

A61K039/395
C07K016/28

US Classification:

424144100, 530388220

Abstract:

The present invention relates to antibodies and related molecules that specifically bind to the Nogo receptor (NogoR). Such antibodies have uses, for example, in the treatment of spinal cord injury, brain trauma, paralysis, degenerative nervous system diseases, and stroke. The invention also relates to nucleic acid molecules encoding anti-NogoR antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same.

US Patent:

20060057582, Mar 16, 2006

Filed:

Aug 21, 2003

Appl. No.:

10/644807

Inventors:

Craig Rosen - Laytonsville MD, US
George Komatsoulis - Silver Spring MD, US
Charles Birse - North Potomac MD, US
Gil Choi - Rockville MD, US
Henrik Olsen - Gaithersburg MD, US
Jian Ni - Germantown MD, US
Adam Bell - Germantown MD, US

International Classification:

C12Q 1/68
C07H 21/04
C12N 9/00

US Classification:

435006000, 435069100, 435183000, 435320100, 435325000, 530350000, 536023200

Abstract:

The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

US Patent:

20070048282, Mar 1, 2007

Filed:

Aug 8, 2006

Appl. No.:

11/500314

Inventors:

Craig Rosen - Laytonsville MD, US
William Haseltine - Washington DC, US
Paul Moore - North Bethesda MD, US
Jason Bock - North Potomac MD, US
Adam Bell - Germantown MD, US
Yanggu Shi - Gaithersburg MD, US
David LaFleur - Washington DC, US

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

A61K 38/21
A61K 38/38
C12P 21/04
C12N 15/00

US Classification:

424085700, 514012000, 530350000, 530351000, 530363000, 435069510, 435069700, 435320100, 435325000

Abstract:

The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.