Adam Gilbert

US Patent:

20200262833, Aug 20, 2020

Filed:

Jun 14, 2018

Appl. No.:

16/625202

Inventors:

- New York NY, US
Michael Aaron Brodney - Newton MA, US
Matthew Frank Brown - Stonington CT, US
Christopher Ryan Butler - Canton MA, US
Adam Matthew Gilbert - Guilford CT, US
Erik Alphie Lachapelle - Uncasville CT, US
Laura Ann McAllister - Arlington MA, US
Daniel Paul Uccello - Colchester CT, US
Lei Zhang - Auburndale MA, US

International Classification:

C07D 471/04
A61P 25/28
A61P 25/30
A61P 25/18

Abstract:

The present invention provides, in part, compounds of Formula I, or an N-oxide thereof, or a pharmaceutically acceptable salt of the compound or the N-oxide, wherein: (R)a, (R)b, (R)c, L, A, and E are as described herein; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds, N-oxides, or salts, and their uses for treating M4-mediated (or M4-associated) disorders including, e.g., Alzheimer's Disease, schizophrenia (e.g., its cognitive and negative symptoms), pain, addiction, and a sleep disorder.

US Patent:

20190382359, Dec 19, 2019

Filed:

Aug 21, 2019

Appl. No.:

16/547037

Inventors:

- NEW YORK NY, US
LAURA ANN MCALLISTER - ARLINGTON MA, US
ELIZABETH MARY BECK - ABINGDON, GB
MICHAEL AARON BRODNEY - NEWTON MA, US
ADAM MATTHEW GILBERT - GUILFORD CT, US
CHRISTOPHER JOHN HELAL - MYSTIC CT, US
DOUGLAS SCOTT JOHNSON - CONCORD MA, US
JUSTIN IAN MONTGOMERY - LEDYARD CT, US
STEVEN VICTOR O'NEIL - EAST LYME CT, US
BRUCE NELSEN ROGERS - BELMONT MA, US
PATRICK ROBERT VERHOEST - NEWTON MA, US
DAMIEN WEBB - BROOKLINE MA, US

Assignee:

PFIZER INC. - NEW YORK NY

International Classification:

C07D 295/14
C07D 493/10
C07D 405/12
C07D 413/14
C07D 405/14
C07F 9/6561
C07D 515/10
C07D 471/08
C07D 211/48
C07D 487/04
C07D 471/10
C07D 401/12
C07D 491/107
C07D 498/10
C07D 403/04
C07D 401/04
C07D 401/14

Abstract:

The present invention provides, in part, compounds of Formula I:and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating MAGL-mediated diseases and disorders including, e.g., pain, an inflammatory disorder, traumatic brain injury, depression, anxiety, Alzheimer's disease, a metabolic disorder, stroke, or cancer.

US Patent:

20180065943, Mar 8, 2018

Filed:

Nov 9, 2017

Appl. No.:

15/808242

Inventors:

- New York NY, US
LAURA ANN MCALLISTER - ARLINGTON MA, US
ELIZABETH MARY BECK - ABINGDON, OXFORDSHIRE, UK
MICHAEL AARON BRODNEY - NEWTON MA, US
ADAM MATTHEW GILBERT - GUILFORD CT, US
CHRISTOPHER JOHN HELAL - MYSTIC CT, US
DOUGLAS SCOTT JOHNSON - CONCORD MA, US
JUSTIN IAN MONTGOMERY - LEDYARD CT, US
STEVEN VICTOR O'NEIL - EAST LYME CT, US
BRUCE NELSEN ROGERS - BELMONT MA, US
PATRICK ROBERT VERHOEST - NEWTON MA, US
DAMIEN WEBB - BROOKLINE MA, US

Assignee:

PFIZER INC. - NEW YORK NY

International Classification:

C07D 295/14
C07D 405/14
C07D 413/14
C07D 515/10
C07D 471/08
C07D 211/48
C07D 487/04
C07D 471/10
C07D 401/12
C07D 491/107
C07D 498/10
C07D 403/04
C07D 401/04
C07D 401/14
C07D 493/10
C07D 405/12
C07F 9/6561

Abstract:

The present invention provides, in part, compounds of Formula I:and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating MAGL-mediated diseases and disorders including, e.g., pain, an inflammatory disorder, traumatic brain injury, depression, anxiety, Alzheimer's disease, a metabolic disorder, stroke, or cancer.

US Patent:

20170029390, Feb 2, 2017

Filed:

Jul 28, 2016

Appl. No.:

15/221658

Inventors:

- New York NY, US
LAURA ANN MCALLISTER - ARLINGTON MA, US
ELIZABETH MARY BECK - EDINBURGH, GB
MICHAEL AARON BRODNEY - NEWTON MA, US
ADAM MATTHEW GILBERT - GUILFORD CT, US
CHRISTOPHER JOHN HELAL - MYSTIC CT, US
DOUGLAS SCOTT JOHNSON - CONCORD MA, US
JUSTIN IAN MONTGOMERY - LEDYARD CT, US
STEVEN VICTOR O'NEIL - EAST LYME CT, US
BRUCE NELSEN ROGERS - BELMONT MA, US
PATRICK ROBERT VERHOEST - NEWTON MA, US
DAMIEN WEBB - BROOKLINE MA, US

Assignee:

PFIZER INC. - NEW YORK NY

International Classification:

C07D 295/14
C07D 401/04
C07D 403/04
C07D 498/10
C07D 491/107
C07D 405/14
C07D 471/10
C07D 487/04
C07D 211/48
C07D 471/08
C07D 515/10
C07F 9/6561
C07D 401/14
C07D 401/12

Abstract:

The present invention provides, in part, compounds of Formula I:and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating MAGL-mediated diseases and disorders including, e.g., pain, an inflammatory disorder, traumatic brain injury, depression, anxiety, Alzheimer's disease, a metabolic disorder, stroke, or cancer.

US Patent:

20140155390, Jun 5, 2014

Filed:

Dec 2, 2013

Appl. No.:

14/093812

Inventors:

- New York NY, US
Eugene Lvovich Piatnitski Chekler - Concord MA, US
Edmund L. Ellsworth - Vicksburg MI, US
Bruce Kipp Erickson - Kalamazoo MI, US
Adam Matthew Gilbert - Guilford CT, US
Anthony P. Ricketts - Kalamazoo MI, US
David P. Thompson - Battle Creek MI, US
Rayomand Jal Unwalla - Bedford MA, US
Patrick Robert Verhoest - Newton MA, US

Assignee:

Pfizer Inc. - New York NY

International Classification:

C07D 417/04
C07C 255/59

US Classification:

5142225, 546143, 514310, 544 8, 558418, 514524

Abstract:

The present invention relates to a compound of Formula 1, 2 or 3:wherein A is N or —CR—, where Ris hydrogen, C-Clinear or branched chain alkyl, etc., Z is —CR—, or, —N—, where Ris hydrogen, C-Clinear or branched chain alkyl,etc.; Ris hydrogen, C-Clinear or branched chain alkyl, etc.; Rare independently hydrogen or C-Clinear or branched chain alkyl; Rand Rare independently hydrogen, C-Clinear or branched chain alkyl, etc.;. Rand Rare independently hydrogen or C-Clinear or branched chain alkyl, etc.; Ris hydrogen, C-Clinear or branched chain alkyl, etc.; Rand Rare independently hydrogen or C-Clinear or branched chain alkyl, etc.; Q is —CO—, —(CH)—, —(CHR)—, or (CRR)—, where Rand Rare independently C-Clinear or branched chain alkyl, aryl, alkylaryl, heteroaryl or alkylheteroaryl; where q is 0, 1, 2, or 3; and, where n is 0, 1, 2, 3, 4 or 5; or, a pharmaceutically acceptable salt thereof, to compositions containing such compounds; and to the uses of such compounds in the treatment of various diseases, particularly, those affected or mediated by the androgen receptor.