Adam M Gilbert

US Patent:

6337326, Jan 8, 2002

Filed:

Nov 6, 2000

Appl. No.:

09/706640

Inventors:

Adam M. Gilbert - Congers NY
Richard E. Mewshaw - King of Prussia PA

Assignee:

American Home Products Corporation - Madison NJ

International Classification:

C07D40308

US Classification:

51421108, 540575

Abstract:

This invention provides novel compounds and methods and compositions using them in the treatment of central nervous system disorders, including depression and anxiety, the compounds having the formula: wherein Ar is an aryl group of 4 to 10 carbon atoms or a heteraryl group of 4 to 10 carbon atoms; R and R are independently selected from hydrogen, straight chain alkyl of 1 to 12 carbon atoms, branched alkyls of 3 to 10 carbon atoms or cycloalkyl of 3 to 10 carbon atoms; R is H, straight chain, branched or cyclic alkyl, halogen, alkoxy, haloalkyl, OH, nitro, nitrile, amino, CN, carboxy, alkoxycarbonyl, alkylcarbonyl, aminocarbonyl and alkylaminocarbonyl; or a pharmaceutically acceptable salt thereof.

US Patent:

6458823, Oct 1, 2002

Filed:

Sep 25, 2001

Appl. No.:

09/963254

Inventors:

Adam Matthew Gilbert - Congers NY
Zhen-jia Chen - Bothell WA

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 314155

US Classification:

514404, 514403, 514406, 514407, 5483611, 5483714

Abstract:

This invention concerns the treatment of smooth muscle spasticity or excess muscle contraction such as urge urinary incontinence with a compound of the formula wherein: R and R are independently straight chain alkyl of 1 to 6 carbon atoms, branched alkyl of 3 to 6 carbons atoms, or cycloalkyl of 3 to 6 carbons atoms where R may be substituted by F, Cl, Br, I, OH, NH , cyano, C -C alkoxy, C -C alkylthio, COOH or COOC -C alkyl; R is an aryl or heteroaryl as defined herein, optionally substituted with 0 to 4 groups selected independently from C -C alkyl, C -C alkoxy, cyano, F, Cl, Br, C -C alkylthio, CO R , CONH , OH, NH , and NO ; n is 0 or 1; R is a straight chain alkyl group of 1 to 10 carbons atoms, a branched alkyl of 3 to 10 carbons, or a cycloalkyl of 3 to 10 carbons; and all crystalline forms and the pharmaceutically acceptable salts thereof.

US Patent:

6632824, Oct 14, 2003

Filed:

May 20, 2002

Appl. No.:

10/151210

Inventors:

Adam M. Gilbert - Congers NY

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 3146

US Classification:

514304, 546126, 546124, 546112, 514299

Abstract:

The present invention includes compounds of formula I wherein A, X, n, Ar , and Ar are defined as set forth herein. These compounds may be used to treat depression. The invention also includes formulations containing these compounds, and methods for making and using compounds of this invention.

US Patent:

6656951, Dec 2, 2003

Filed:

Apr 23, 2002

Appl. No.:

10/128057

Inventors:

Adam M. Gilbert - Congers NY
Gary P. Stack - Ambler PA

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 3146

US Classification:

514304, 546126, 546125, 544335, 544180, 544182, 544333, 514256, 514241, 514242

Abstract:

Compounds of the formula: are useful for treating the cognitive deficits due to aging, stroke, head trauma, Alzheimers disease or other neurodegenerative diseases, or schizophrenia and also treatment of disorders related to excessive serotonergic stimulation, such as anxiety, aggression and stress, and for the control of various physiological phenomena, such as appetite, thermoregulation, sleep and sexual behavior, which are known to be, at least in part, under serotonergic influence.

US Patent:

7799915, Sep 21, 2010

Filed:

Oct 13, 2005

Appl. No.:

11/248495

Inventors:

Fuk-Wah Sum - Pomona NY, US
Dennis William Powell - Cortlandt Manor NY, US
Yixian Zhang - Pearl River NY, US
Lijing Chen - Cupertino CA, US
Scott Lee Kincaid - Middletown NY, US
Lee Dalton Jennings - Chestnut Ridge NY, US
Yongbo Hu - River Edge NJ, US
Adam Matthew Gilbert - Congers NY, US
Matthew Gregory Bursavich - Tuckahoe NY, US

Assignee:

Wyeth LLC - Madison NJ

International Classification:

C07D 239/02
C07D 401/00
C07D 403/00
C07D 405/00
C07D 409/00
C07D 411/00
C07D 413/00
C07D 417/00
C07D 419/00

US Classification:

544330, 544331

Abstract:

The present invention relates to compounds of formula I:.

US Patent:

7947712, May 24, 2011

Filed:

Aug 23, 2007

Appl. No.:

11/895222

Inventors:

Matthew G. Bursavich - Tuckahoe NY, US
Sabrina Lombardi - Wilton CT, US
Adam M. Gilbert - Congers NY, US
Leif Mark Laakso - Chester NY, US
Gulnaz Khafizova - West Nyack NY, US
David Brian How - Nyack NY, US
Joshua James Sabatini - White Plains NY, US
Jeremy Clemens - New City NY, US

Assignee:

Wyeth LLC - Madison NJ

International Classification:

C07D 215/04
A61K 31/04

US Classification:

514312, 546159, 546167

Abstract:

The present invention relates to 8-Hydroxyquinoline Compounds; compositions comprising an 8-Hydroxyquinoline Compound; and methods for treating or preventing a metalloproteinase-related disorder, such as, an arthritic disorder, osteoarthritis, malignant neoplasm, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, atherosclerosis, age-related macular degeneration, myocardial infarction, a corneal ulceration, an ocular surface disease, hepatitis, an aortic aneurysm, tendonitis, a central nervous system disorder, abnormal wound healing, angiogenesis, restenosis, cirrhosis, multiple sclerosis, glomerulonephritis, graft versus host disease, diabetes, an inflammatory bowel disease, shock, invertebral disc degeneration, stroke, osteopenia or a periodontal disease or comprising administering an effective dose of an 8-Hydroxyquinoline Compound to a mammal in need thereof.

US Patent:

8299090, Oct 30, 2012

Filed:

Jun 18, 2009

Appl. No.:

12/487247

Inventors:

Roberto Pellicciari - Perugia, IT
Flavio Moroni - Florence, IT
Adam Matthew Gilbert - Congers NY, US

International Classification:

C07D 417/02
A61K 31/4355
A61K 31/4365

US Classification:

514293, 546 83, 546 84

Abstract:

The present invention relates to substituted thiazolyl- and oxazoyl-isoquinolinones that act, for example, as modulators of poly(ADP-ribose) polymerase (PARP). The present invention also relates to processes for the preparation of substituted thiazolyl- and oxazolyl-isoquinolinones and to their use in treating various diseases and disorders.

US Patent:

8633215, Jan 21, 2014

Filed:

Jun 18, 2009

Appl. No.:

12/487309

Inventors:

Roberto Pellicciari - Perugia, IT
Flavio Moroni - Florence, IT
Eric Christian Hansen - Ridgewood NJ, US
Adam Matthew Gilbert - Congers NY, US
Peter John Larkin - Trumbull CT, US

International Classification:

C07D 491/048
A61K 31/4355
A61K 31/4365

US Classification:

514292, 546 81

Abstract:

The present invention relates to substituted thienyl- and furanyl-isoquinolinones that act, for example, as modulators of poly(ADP-ribose) polymerase (PARP). The present invention also relates to processes for the preparation of substituted thienyl and furanyl-isoquinolinones and to their use in treating various diseases and disorders.