Adrian M Lowe

US Patent:

20020052472, May 2, 2002

Filed:

Jan 12, 2001

Appl. No.:

09/759097

Inventors:

David Beattie - Boston MA, US
Robert Deresiewicz - Boston MA, US
Adrian Lowe - Brighton MA, US
Michael Lonetto - Collegeville PA, US
John Hodgson - Paris, FR
Richard Nicholas - Collegeville PA, US
Leslie Palmer - Audubon PA, US
Julie Pratt - Wigston, GB

International Classification:

C12N015/09
C07K001/00
C07K014/00
C07K017/00

US Classification:

530/350000

Abstract:

The invention provides ama polypeptides and polynucleotides encoding ama polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ama polypeptides to screen for antibacterial compounds.

US Patent:

20050049201, Mar 3, 2005

Filed:

Dec 11, 2002

Appl. No.:

10/498292

Inventors:

Adrian Lowe - Newton MA, US
Gerard Colpas - Holden MA, US
Maureen Hamilton - Littleton MA, US
Michael Salcius - Oxford MA, US
Mitchell Sanders - West Boylston MA, US

International Classification:

A61K038/08
C07K007/06
G01N033/558

US Classification:

514017000, 530330000, 436514000

Abstract:

Thymosin beta-4 (TB4), Thymosin beta-9 (TB9), and acyl-CoA binding protein (ACBP) are two proteins that possess the ability to bind lead in human tissue. These two proteins have a high affinity lead-binding region with a dissociation constant (K) of about 10M that allows for a strong interaction between the metal and the protein. These proteins and their analogs and lead-binding fragments can be used to detect and remove lead from various media.

US Patent:

20050142622, Jun 30, 2005

Filed:

Jan 31, 2003

Appl. No.:

10/502882

Inventors:

Mitchell Sanders - West Boylston MA, US
Adrian Lowe - Newton MA, US
Maureen Hamilton - Littleton MA, US
Gerard Colpas - Holden MA, US

International Classification:

G01N033/554
G01N033/569
C12Q001/37

US Classification:

435007320, 435023000

Abstract:

Described herein are methods of detecting a wound infection and for detecting the presence or absence of microorganisms, for example, wound pathogens in a sample, by contacting a sample with an enzyme produced and/or secreted by the bacteria, and detecting modification or the absence of modification of the substrate, as an indicator of the presence or absence of the enzyme in the sample. The present invention also features a biosensor for detecting the presence or absence of bacteria in a sample.

US Patent:

20130193052, Aug 1, 2013

Filed:

Jan 30, 2013

Appl. No.:

13/754540

Inventors:

William J. Wilde - Watertown MA, US
Adrian Lowe - Newton MA, US
Michael Shamashkin - Woburn MA, US
Peter Rezac - Berlin MA, US
Alexander Slocum - Bow NH, US
Travis Ward - Newton MA, US

Assignee:

REPLIGEN CORPORATION - Waltham MA

International Classification:

B01D 15/22

US Classification:

2101982, 29428, 13731501

Abstract:

If one manufactures chromatography column tubes from plastic/thermoplastic or composite materials (such as polypropylene (PP), polyethylene (PE), polyamides, acetals, or glass-filled plastics, such as glass-fiber plastics) and secures at least one of two flow distributors within the column tube with a tight interference or press fit, the resulting chromatography columns reduce or avoid the formation of dead zones around the press fit flow distributor and have an infinitely adjustable packing medium volume, also known as the medium “bed height.”

US Patent:

20140051089, Feb 20, 2014

Filed:

Jul 23, 2013

Appl. No.:

13/948865

Inventors:

Adrian M. Lowe - Newton MA, US
Maureen A. Hamilton - Littleton MA, US
Gerard J. Colpas - Holden MA, US

Assignee:

Systagenix Wound Management (US), Inc. - Quincy MA

International Classification:

C12Q 1/04
C12Q 1/10
C12Q 1/44
C12Q 1/14
C12Q 1/34
C12Q 1/37

US Classification:

435 615, 435 18, 435 23, 435 19, 4352877, 4352871, 4352883, 4352881, 4352872, 435 34, 435 36, 435 38

Abstract:

Described herein are methods of detecting a wound infection and for detecting the presence or absence of microorganisms, for example, wound pathogens in a sample, by contacting a sample with an enzyme produced and/or secreted by the bacteria, and detecting modification or the absence of modification of the substrate, as an indicator of the presence or absence of the enzyme in the sample. The present invention also features a biosensor for detecting the presence or absence of bacteria in a sample.

US Patent:

61975494, Mar 6, 2001

Filed:

Mar 19, 1999

Appl. No.:

9/147926

Inventors:

Richard O Nicholas - Collegeville PA
Leslie Marie Palmer - Audubon PA
Julie M Pratt - Wigston, GB
David T. Beattie - Boston MA
Robert L Deresiewicz - Boston MA
Adrian M Lowe - Brighton MA
Michael A Lonetto - Collegeville PA
John E Hodgson - Paris, FR

Assignee:

Brigham & Women's Hospital - Boston MA
Virus Research Institute - Cambridge MA
SmithKline Beecham Corporation - Philadelphia PA
SmithKline Beecham, plc

International Classification:

C12N 1509
C12N 120
C12N 1500
C12N 500
C07H 2104

US Classification:

435 693

Abstract:

This invention provides ama polypeptides and polynucleotides encoding ama polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ama polypeptides to screen for antibacterial compounds.

US Patent:

62388878, May 29, 2001

Filed:

Mar 19, 1999

Appl. No.:

9/269258

Inventors:

David T Beattie - Boston MA
Robert L Deresiewicz - Boston MA
Adrian M Lowe - Brighton MA
Michael A Lonetto - Collegeville PA
John E Hodgson - Paris, FR
Richard O Nicholas - Collegeville PA
Leslie Marie Palmer - Audubon PA
Julie M Pratt - Wigston, GB

Assignee:

Brigham & Women's Hospital - Boston MA
Virus Research Institute - Cambridge MA
SmithKline Beecham Corporation - Philadelphia PA
SmithKline Beecham plc

International Classification:

C12N 1509

US Classification:

435 693

Abstract:

This invention provides frr polypeptides and polynucleotides encoding frr polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing frr polypeptides to screen for antibacterial compounds.

US Patent:

61269379, Oct 3, 2000

Filed:

Mar 19, 1999

Appl. No.:

9/147930

Inventors:

David T Beattie - Boston MA
Robert L Deresiewicz - Boston MA
Adrian M Lowe - Brighton MA
Michael A Lonetto - Collegeville PA
John E Hodgson - Paris, FR
Richard O Nicholas - Collegeville PA
Leslie Marie Palmer - Audubon PA
Julie M Pratt - Leichester, GB

Assignee:

SmithKline Beecham Corporation - Philadelphia PA
SmithKline Beecham plc
Virus Research Institute - Cambridge MA
Brigham & Women's Hospital - Boston MA

International Classification:

A61K 3846
A61K 3848
C12N 916
C12N 952
C07M 2104

US Classification:

424 946

Abstract:

The invention provides clpL polypeptides, polynucleotides encoding clpL polypeptides and methods for producing such polypeptides by recombinant techniques.