Aimee D Reed

US Patent:

6849634, Feb 1, 2005

Filed:

Dec 7, 2001

Appl. No.:

10/004867

Inventors:

Serge Beaudoin - Morrisvile NC, US
Aimee D. Reed - Willoughby OH, US
Michael F. Gross - Durham NC, US

Assignee:

ICAgen - Durham NC

International Classification:

A61K 3118
C07C31107

US Classification:

514256, 514249, 5142581, 514275, 514278, 514299, 514388, 514398, 514399, 514471, 514472, 514601, 514602, 514605, 544230, 544235, 544253, 544316, 544332, 544335, 544349, 546 18, 546112, 546304, 546314, 5483331, 5483355, 549480, 549492, 564 80, 564 92

Abstract:

Compounds useful as potassium channel inhibitors and especially useful for the treatment of cardiac arrhythmias and cell proliferative disorders are described.

US Patent:

7119112, Oct 10, 2006

Filed:

Aug 14, 2003

Appl. No.:

10/641686

Inventors:

Aimee D. Reed - Willoughby OH, US
Robert N. Atkinson - Raleigh NC, US

Assignee:

ICAgen, Inc. - Durham NC

International Classification:

A61K 31/425
C07D 275/02

US Classification:

514365, 514374, 514364, 548214, 548235, 548131, 549491

Abstract:

Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides sulfonamides, and compositions and methods utilizing sulfonamides that are useful in the treatment of diseases by blocking potassium channels associated with the onset or recurrence of the indicated conditions. Exemplary diseases treatable with the compounds, compositions and methods of the invention include sickle cell disease and glaucoma.

US Patent:

20050267032, Dec 1, 2005

Filed:

May 23, 2005

Appl. No.:

11/136243

Inventors:

Alan Fulp - Willow Springs NC, US
Aimee Reed - Willoughby OH, US
Xiadong Wang - Chapel Hill NC, US

Assignee:

Icagen, Inc. - Durham NC

International Classification:

A61K038/18
A61K031/381

US Classification:

514012000, 514079000, 514447000, 514575000, 549005000, 549076000

Abstract:

Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides sulfone-containing prodrugs, and compositions and methods utilizing sulfone-containing prodrugs that are useful in the treatment of diseases by blocking potassium channels associated with the onset or recurrence of the indicated conditions. Exemplary diseases treatable with the compounds, compositions and methods of the invention include sickle cell disease and glaucoma.

US Patent:

20070004784, Jan 4, 2007

Filed:

Sep 7, 2006

Appl. No.:

11/517906

Inventors:

Aimee Reed - Willoughby OH, US
Robert Atkinson - Raleigh NC, US

Assignee:

Icagen, Inc. - Durham NC

International Classification:

A61K 31/427
A61K 31/4192
A61K 31/4178
A61K 31/4025
C07D 417/02
C07D 405/02

US Classification:

514359000, 514406000, 548255000, 548335500, 514365000, 548203000, 514397000, 514422000, 548311100, 548517000

Abstract:

Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides sulfonamides, and compositions and methods utilizing sulfonamides that are useful in the treatment of diseases by blocking potassium channels associated with the onset or recurrence of the indicated conditions. Exemplary diseases treatable with the compounds, compositions and methods of the invention include sickle cell disease and glaucoma.

US Patent:

20070082920, Apr 12, 2007

Filed:

Oct 6, 2005

Appl. No.:

11/244614

Inventors:

Yongsheng Song - Guilford CT, US
Yongchun Hou - Mentor OH, US
Sandeep Gupta - Concord OH, US
Aimee Reed - Willoughby OH, US
Debasis Ghosh - Perrysburg OH, US

International Classification:

A61K 31/519
C07D 487/02

US Classification:

514264100, 544250000, 544279000, 514267000

Abstract:

Disclosed herein are pyrido[2,3-d]pyrimidines having the structure