Brian L. Henry - Pittsburgh PA, US Aiye Liang - North Charleston SC, US Jay Thakkar - Denver CO, US John B. Mangrum - Richmond VA, US Ivo Torres Filho - San Antonio TX, US Bruce D. Spiess - Manakin-Sabot VA, US Masahiro Sakagami - Richmond VA, US Bhawana Saluja - North Bethesda MD, US
Cinnamic acid-based oligomers and therapeutic uses thereof are provided. The oligomers are used as anti-inflammation agents, inhibitors of elastase and anti-oxidants, and in some cases (e. g. the treatment of lung disorders such as lung cancer) all three activities are simultaneously beneficial. Subsets of the oligomers (e. g. β-O4 and β-5 trimers and tetramers) are used as anticoagulants.
Umesh R. Desai - Glen Allen VA, US Brian L. Henry - Pittsburgh PA, US Aiye Liang - North Charleston SC, US Jay Thakkar - Denver CO, US John B. Mangrum - Richmond VA, US Ivo Torres Filho - Glen Allen VA, US Bruce D. Spiess - Manakin-Sabot VA, US Masahiro Sakagami - Richmond VA, US Bhawana Saluja - N. Bethesda MD, US
Cinnamic acid-based oligomers and therapeutic uses thereof are provided. The oligomers are used as anti-inflammation agents, inhibitors of elastase and anti-oxidants, and in some cases (e.g. the treatment of lung disorders such as lung cancer) all three activities are simultaneously beneficial. Subsets of the oligomers (e.g. β-O4 and β-5 trimers and tetramers) are used as anticoagulants.
Brian L. Henry - Pittsburgh PA, US Aiye Liang - North Charleston SC, US Jay Thakkar - Denver CO, US John B. Mangrum - Richmond VA, US Ivo Torres Filho - San Antonio TX, US Bruce D. Spiess - Manakin-Sabot VA, US Masahiro Sakagami - Richmond VA, US Bhawana Saluja - North Bethesda MD, US
Assignee:
Virginia Commonwealth University - Richmond VA
International Classification:
C07D 307/84
US Classification:
514469, 549468
Abstract:
Cinnamic acid-based oligomers and therapeutic uses thereof are provided. The oligomers are used as anti-inflammation agents, inhibitors of elastase and anti-oxidants, and in some cases (e.g. the treatment of lung disorders such as lung cancer) all three activities are simultaneously beneficial. Subsets of the oligomers (e.g. β-O4 and β-5 trimers and tetramers) are used as anticoagulants.
Charleston Southern University - Charleston, South Carolina Area since Aug 2011
Assistant Professor of Chemistry
Virginia Commonwealth University - Richmond, Virginia Area Feb 2010 - Aug 2011
Research Assistant Professor
Virginia State University - Petersburg, Virginia Aug 2010 - Jul 2011
Adjunct Professor
Virginia Commonwealth University - Richmond, Virginia Area Jun 2006 - Jan 2010
Postdoctoral Associate
Education:
Dalian Institute of Chemical Physics, Chinese Academy of Sciences 2001 - 2006
Ph.D., Analytical Chemsitry
Skills:
Research Molecular Biology Uv/Vis Hplc Nmr Mass Spectrometry Analytical Chemistry Spectroscopy Fluorescence Capillary Electrophoresis Teaching Uv/Vis Spectroscopy High Performance Liquid Chromatography Instructional Technology Grant Writing Collaboration Training Spr
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